Post-translational regulation of PTEN catalytic function and protein stability in the hibernating 13-lined ground squirrel

• Published in: Biochimica et biophysica acta Vol. 1850; no. 11; pp. 2196 - 2202
• Main Authors: Wu, Cheng-Wei, Bell, Ryan A., Storey, Kenneth B.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2015
• Subjects: Amino Acid Sequence; Animals; Biocatalysis; energy; enzyme activity; gene expression; Ground squirrels; Hibernation; Hibernation - physiology; insulin; insulin receptors; Insulin signaling pathway; malachite green; messenger RNA; Molecular Sequence Data; Phosphorylation; Protein phosphatase; Protein Stability; Protein-Serine-Threonine Kinases - physiology; proteolysis; PTEN Phosphohydrolase - chemistry; PTEN Phosphohydrolase - physiology; reverse transcriptase polymerase chain reaction; Sciuridae; Sciuridae - metabolism; signal transduction; skeletal muscle; transcription (genetics); translation (genetics); urea; Insulin signaling pathway; Ground squirrels; Phosphorylation; Protein phosphatase; Hibernation

The insulin signaling pathway functions as a major regulator of many metabolic and cellular functions, and has been shown to be reversibly suppressed in many species during hibernation. This study characterized the regulation of PTEN phosphatase, a negative regulator of the insulin receptor network,...