Thioredoxin (Trx1) regulates CD4 membrane domain localization and is required for efficient CD4-dependent HIV-1 entry

• Published in: Biochimica et biophysica acta Vol. 1860; no. 9; pp. 1854 - 1863
• Main Authors: Moolla, Naazneen, Killick, Mark, Papathanasopoulos, Maria, Capovilla, Alexio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2016
• Subjects: antibodies; antiretroviral properties; CCR5 receptor; CD4; CD4 Antigens - metabolism; Cell Line, Tumor; Cell Membrane - drug effects; Cell Membrane - metabolism; Cell Membrane - virology; centrifugation; confocal microscopy; disulfide bonds; Dithionitrobenzoic Acid - pharmacology; flow cytometry; glycoproteins; HeLa Cells; HIV-1; HIV-1 - pathogenicity; Human immunodeficiency virus 1; Humans; Lipid raft; major histocompatibility complex; Major Histocompatibility Complex - physiology; Membrane Microdomains - metabolism; Oxidation-Reduction - drug effects; pathogenicity; Receptors, CCR5 - metabolism; Redox; T-lymphocytes; T-Lymphocytes - drug effects; T-Lymphocytes - metabolism; T-Lymphocytes - virology; Thioredoxin; Thioredoxins - metabolism; Virus Internalization - drug effects; HIV-1; TFR; TCR; Lipid raft; DTNB; Grx1; Redox; MHC; Thioredoxin; Trx1; MBCD; CD4; APC; HIV; DRM
• ISSN: 0304-4165; 0006-3002; 1872-8006
• DOI: 10.1016/j.bbagen.2016.05.030

CD4 is a glycoprotein expressed on the surfaces of certain immune cells. On lymphocytes, an important function of CD4 is to co-engage Major Histocompatibility Complex (MHC) molecules with the T Cell Receptor (TCR), a process that is essential for antigen-specific activation of T cells. CD4 localizes...