Antitumour activity of resveratrol on human melanoma cells: A possible mechanism related to its interaction with malignant cell telomerase

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 11; pp. 2843 - 2851
• Main Authors: Platella, Chiara, Guida, Serena, Bonmassar, Laura, Aquino, Angelo, Bonmassar, Enzo, Ravagnan, Giampiero, Montesarchio, Daniela, Roviello, Giovanni N., Musumeci, Domenica, Fuggetta, Maria Pia
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2017
• Subjects: antineoplastic activity; antineoplastic agents; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - chemistry; antioxidants; bioassays; Biophysical Phenomena; cell growth; Cell Line, Tumor; Cell Proliferation - drug effects; Circular Dichroism; copper; Copper - chemistry; cytotoxicity; DNA; enzyme activity; fluorescence; G-quadruplex DNA; G-Quadruplexes - drug effects; hTERT; Humans; mechanism of action; melanoma; Melanoma - drug therapy; Melanoma - genetics; Melanoma - pathology; Melanoma cells; messenger RNA; Nucleic Acid Conformation; nucleotide sequences; plant products; Resveratrol; Spectrometry, Fluorescence; Spectrum Analysis; Stilbenes - administration & dosage; Stilbenes - chemistry; telomerase; Telomerase - chemistry; Telomerase - genetics; Telomerase activity; Telomeres; Telomeres; G-quadruplex DNA; hTERT; Telomerase activity; Melanoma cells; Resveratrol

trans-Resveratrol (tRES) is a polyphenolic stilbene found in plant products which has attracted great attention because of its antioxidant, anti-inflammatory and anticancer properties. The possible correlation between tRES-induced suppression of melanoma cell growth and its influence on telomerase e...