Monte Carlo simulation of gold nanoparticles for X-ray enhancement application

• Published in: Biochimica et biophysica acta. General subjects Vol. 1867; no. 4; p. 130318
• Main Authors: Dheyab, Mohammed Ali, Aziz, Azlan Abdul, Rahman, Azhar Abdul, Ashour, Nabeel Ibrahim, Musa, Ahmed Sadeq, Braim, Farhank Saber, Jameel, Mahmood S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2023
• Subjects: Au NPs; Computer Simulation; DNA; DNA damage; Dose enhancement factor (DEF); Geant4; Gold; irradiation; Metal Nanoparticles; Monte Carlo Method; Monte Carlo simulation; nanogold; neoplasms; prediction; Radiation therapy; Radiosensitization; X-radiation; X-Rays; Radiosensitization; Radiation therapy; Dose enhancement factor (DEF); Au NPs; Monte Carlo simulation; Geant4

Gold nanoparticles (Au NPs) are regarded as potential agents that enhance the radiosensitivity of tumor cells for theranostic applications. To elucidate the biological mechanisms of radiation dose enhancement effects of Au NPs as well as DNA damage attributable to the inclusion of Au NPs, Monte Carl...