Tandem application of ligand-based virtual screening and G4-OAS assay to identify novel G-quadruplex-targeting chemotypes - Musumeci, Domenica; Amato, Jussara; Zizza, Pasquale; Platella, Chiara; Cosconati, Sandro; Cingolani, Chiara; Biroccio, Annamaria; Novellino, Ettore; Randazzo, Antonio; Giancola, Concetta; Pagano, Bruno; Montesarchio, Daniela (Biochimica et biophysica acta. General subjects, 2017)
Keywords: adverse effects; Anticancer agents; antineoplastic agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacology; Binding Sites; Cell Line, Transformed; cell proliferation; Cell Proliferation - drug effects; Cell Survival - drug effects; chemotypes; DNA; DNA damage; DNA, Neoplasm - chemistry; DNA, Neoplasm - drug effects; DNA, Neoplasm - genetics; DNA, Neoplasm - metabolism; Dose-Response Relationship, Drug; Drug Design; Drug discovery; fluorescent antibody technique; G-quadruplex; G-Quadruplexes - drug effects; Guanosine - chemistry; Guanosine - metabolism; High-Throughput Screening Assays; Humans; Ligands; Models, Molecular; neoplasms; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - pathology; screening; Small Molecule Libraries; Structure-Activity Relationship; Telomere - chemistry; Telomere - drug effects; Telomere - genetics; Telomere - metabolism; telomeres; Time Factors; Virtual screening; Virtual screening; Anticancer agents; Drug discovery; G-quadruplex