Inhibition of epidermal growth factor receptor signaling prohibits metastasis of gastric cancer via downregulation of MMP7 and MMP13

• Published in: Tumor biology Vol. 35; no. 11; pp. 10891 - 10896
• Main Authors: Ye, Yinghai, Zhou, Xiaocong, Li, Xiaoyang, Tang, Yinhe, Sun, Yusheng, Fang, Jun
• Format: Journal Article
• Language: English
• Published: United States Springer Nature B.V 01.11.2014
• Subjects: Blotting, Western; Cell Movement; Down-Regulation; Enzyme Inhibitors - pharmacology; Epidermal growth factor; Epidermal Growth Factor - pharmacology; Gastric cancer; Humans; Matrix Metalloproteinase 13 - chemistry; Matrix Metalloproteinase 13 - genetics; Matrix Metalloproteinase 13 - metabolism; Matrix Metalloproteinase 7 - chemistry; Matrix Metalloproteinase 7 - genetics; Matrix Metalloproteinase 7 - metabolism; Metastasis; Mitogen-Activated Protein Kinases - genetics; Mitogen-Activated Protein Kinases - metabolism; Phosphorylation; Phosphorylation - drug effects; Protein expression; Real-Time Polymerase Chain Reaction; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Receptor, Epidermal Growth Factor - genetics; Receptor, Epidermal Growth Factor - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Signal transduction; Signal Transduction - drug effects; Stomach Neoplasms - drug therapy; Stomach Neoplasms - metabolism; Stomach Neoplasms - secondary; Tumor Cells, Cultured

The molecular pathway regulating gastric carcinoma (GC) invasiveness and metastasis remains elusive. Here, we detected significant increase in the phosphorylated epidermal growth factor receptor (pEGFR), MMP7, and MMP13 in the resected GC, compared with the adjacent normal tissue, in patients. Moreo...