Associations of co-exposure to polycyclic aromatic hydrocarbons and metals with hyperuricemia risk in Chinese coke oven workers: Mediating roles of oxidative damage

• Published in: Environmental pollution (1987) Vol. 318; p. 120891
• Main Authors: Guo, Chaofan, Liu, Xin, Liao, Xiaojing, Wu, Haimei, Zhang, Zhaorui, Wu, Dehua, Ma, Rui, Huang, Yongshun, Zhao, Na, Xiao, Yongmei, Deng, Qifei
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.02.2023
• Subjects: 8-Hydroxy-2'-Deoxyguanosine; blood; Coke; Cross-Sectional Studies; DNA Damage; East Asian People; Humans; hyperuricemia; Hyperuricemia - chemically induced; Hyperuricemia - epidemiology; Interaction; Mediation analysis; Metals; Occupational Exposure - adverse effects; Occupational Exposure - analysis; ovens; Oxidative Stress; PAH-metal co-exposure; pollution; Polycyclic Aromatic Hydrocarbons - toxicity; risk factors; Risk of hyperuricemia; Rubidium; Strontium; uric acid; Oxidative stress; OH-Flu; OH-Phe; ADE; anti-NMDA; PAH-metal co-exposure; aMed score; OH-Nap; BPDE-Alb; ΣOH-Phe; Risk of hyperuricemia; 8-iso-PGF2α; MSE; BMI; eGFR; 8-OH-dG; ACME; COEs; Interaction; ln-transformed; MDRD; LOQ; CV; ROS; PAHs; 1-OH-Pyr; Mediation analysis; ELISA

Ubiquitous polycyclic aromatic hydrocarbons (PAHs) and metals could induce hyperuricemia and oxidative damage individually, while their co-exposure effects on hyperuricemia risk and the potential roles of oxidative damage in these health outcomes remain poorly understood. We conducted a cross-sectio...