Mechanotransduction: Exploring New Therapeutic Avenues in Central Nervous System Pathology

Cells are continuously exposed to physical forces and the central nervous system (CNS) is no exception. Cells dynamically adapt their behavior and remodel the surrounding environment in response to forces. The importance of mechanotransduction in the CNS is illustrated by exploring its role in CNS p...

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Published inFrontiers in neuroscience Vol. 16; p. 861613
Main Authors Rocha, Daniela Nogueira, Carvalho, Eva Daniela, Relvas, João Bettencourt, Oliveira, Maria José, Pêgo, Ana Paula
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 28.04.2022
Subjects
central nervous system
extracellular matrix
mechanobiology
mechanotransduction
neurodegenerative disorders
Neuroscience
mechanobiology
neurodegenerative disorders
mechanotransduction
extracellular matrix
central nervous system
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Abstract Cells are continuously exposed to physical forces and the central nervous system (CNS) is no exception. Cells dynamically adapt their behavior and remodel the surrounding environment in response to forces. The importance of mechanotransduction in the CNS is illustrated by exploring its role in CNS pathology development and progression. The crosstalk between the biochemical and biophysical components of the extracellular matrix (ECM) are here described, considering the recent explosion of literature demonstrating the powerful influence of biophysical stimuli like density, rigidity and geometry of the ECM on cell behavior. This review aims at integrating mechanical properties into our understanding of the molecular basis of CNS disease. The mechanisms that mediate mechanotransduction events, like integrin, Rho/ROCK and matrix metalloproteinases signaling pathways are revised. Analysis of CNS pathologies in this context has revealed that a wide range of neurological diseases share as hallmarks alterations of the tissue mechanical properties. Therefore, it is our belief that the understanding of CNS mechanotransduction pathways may lead to the development of improved medical devices and diagnostic methods as well as new therapeutic targets and strategies for CNS repair.
AbstractList Cells are continuously exposed to physical forces and the central nervous system (CNS) is no exception. Cells dynamically adapt their behavior and remodel the surrounding environment in response to forces. The importance of mechanotransduction in the CNS is illustrated by exploring its role in CNS pathology development and progression. The crosstalk between the biochemical and biophysical components of the extracellular matrix (ECM) are here described, considering the recent explosion of literature demonstrating the powerful influence of biophysical stimuli like density, rigidity and geometry of the ECM on cell behavior. This review aims at integrating mechanical properties into our understanding of the molecular basis of CNS disease. The mechanisms that mediate mechanotransduction events, like integrin, Rho/ROCK and matrix metalloproteinases signaling pathways are revised. Analysis of CNS pathologies in this context has revealed that a wide range of neurological diseases share as hallmarks alterations of the tissue mechanical properties. Therefore, it is our belief that the understanding of CNS mechanotransduction pathways may lead to the development of improved medical devices and diagnostic methods as well as new therapeutic targets and strategies for CNS repair.
Author Pêgo, Ana Paula
Oliveira, Maria José
Relvas, João Bettencourt
Rocha, Daniela Nogueira
Carvalho, Eva Daniela
AuthorAffiliation 4 Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto , Porto , Portugal
1 Instituto de Engenharia Biomédica (INEB), Universidade do Porto , Porto , Portugal
5 Departamento de Biomedicina, Faculdade de Medicina, Universidade do Porto , Porto , Portugal
6 Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto , Porto , Portugal
2 Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto , Porto , Portugal
3 Faculdade de Engenharia (FEUP), Universidade do Porto , Porto , Portugal
AuthorAffiliation_xml – name: 6 Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto , Porto , Portugal
– name: 2 Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto , Porto , Portugal
– name: 5 Departamento de Biomedicina, Faculdade de Medicina, Universidade do Porto , Porto , Portugal
– name: 3 Faculdade de Engenharia (FEUP), Universidade do Porto , Porto , Portugal
– name: 4 Instituto de Biologia Molecular e Celular (IBMC), Universidade do Porto , Porto , Portugal
– name: 1 Instituto de Engenharia Biomédica (INEB), Universidade do Porto , Porto , Portugal
Author_xml – sequence: 1
  givenname: Daniela Nogueira
  surname: Rocha
  fullname: Rocha, Daniela Nogueira
  organization: Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal
– sequence: 2
  givenname: Eva Daniela
  surname: Carvalho
  fullname: Carvalho, Eva Daniela
  organization: Faculdade de Engenharia (FEUP), Universidade do Porto, Porto, Portugal
– sequence: 3
  givenname: João Bettencourt
  surname: Relvas
  fullname: Relvas, João Bettencourt
  organization: Departamento de Biomedicina, Faculdade de Medicina, Universidade do Porto, Porto, Portugal
– sequence: 4
  givenname: Maria José
  surname: Oliveira
  fullname: Oliveira, Maria José
  organization: Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal
– sequence: 5
  givenname: Ana Paula
  surname: Pêgo
  fullname: Pêgo, Ana Paula
  organization: Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Universidade do Porto, Porto, Portugal
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Keywords mechanobiology
neurodegenerative disorders
mechanotransduction
extracellular matrix
central nervous system
Language English
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Edited by: Cristina Lanni, University of Pavia, Italy
This article was submitted to Neurodegeneration, a section of the journal Frontiers in Neuroscience
Reviewed by: Fabrizio Biundo, Albert Einstein College of Medicine, United States; Michael Susithiran Samuel, Centre for Cancer Biology (CCB), Australia
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Snippet Cells are continuously exposed to physical forces and the central nervous system (CNS) is no exception. Cells dynamically adapt their behavior and remodel the...
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StartPage 861613
SubjectTerms central nervous system
extracellular matrix
mechanobiology
mechanotransduction
neurodegenerative disorders
Neuroscience
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Title Mechanotransduction: Exploring New Therapeutic Avenues in Central Nervous System Pathology
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https://pubmed.ncbi.nlm.nih.gov/PMC9096357
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Volume 16
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