Semi-synthesis of cyclosporins
Since its isolation in 1970, and discovery of its potent inhibitory activity on T-cell proliferation, cyclosporin A (CsA) has been shown to play a significant role in diverse fields of biology. Furthermore, chemical modification of CsA has led to analogs with distinct biological activities associate...
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| Published in | Biochimica et biophysica acta Vol. 1850; no. 10; pp. 2121 - 2144 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
01.10.2015
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| Subjects | |
| Online Access | Get full text |
| ISSN | 0304-4165 0006-3002 1872-8006 |
| DOI | 10.1016/j.bbagen.2015.02.008 |
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| Abstract | Since its isolation in 1970, and discovery of its potent inhibitory activity on T-cell proliferation, cyclosporin A (CsA) has been shown to play a significant role in diverse fields of biology. Furthermore, chemical modification of CsA has led to analogs with distinct biological activities associated with its protein receptor family, cyclophilins.
This review systematically collates the synthetic chemistry performed at each of the eleven amino acids, and provides examples of the utility of such transformations. The various modifications of CsA are traced from early, modest chemistry performed at the unique Bmt residue, through the remarkable use of a polyanion enolate that can be stereoselectively manipulated, and onto application of more recently developed olefin metathesis chemistry to prepare new CsA derivatives with unexpected biological activity.
The myriad biological activities of CsA and its synthetic derivatives have inspired the development of new approaches to modify the CsA ring. In turn, these new CsA derivatives have served as tools in the discovery of new roles for cyclophilins.
This review provides information on the types of cyclosporin derivatives that are available to the many biologists working in this field, and should be of value to the medicinal chemist trying to discover drugs based on CsA. This article is part of a Special Issue entitled Proline-directed foldases: Cell signaling catalysts and drug targets.
•A review of cyclosporine compounds available for biological investigation•Overview of the biological activity of modified cyclosporins•A systematic review of chemistry applied to cyclosporine A |
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| AbstractList | Since its isolation in 1970, and discovery of its potent inhibitory activity on T-cell proliferation, cyclosporin A (CsA) has been shown to play a significant role in diverse fields of biology. Furthermore, chemical modification of CsA has led to analogs with distinct biological activities associated with its protein receptor family, cyclophilins.This review systematically collates the synthetic chemistry performed at each of the eleven amino acids, and provides examples of the utility of such transformations. The various modifications of CsA are traced from early, modest chemistry performed at the unique Bmt residue, through the remarkable use of a polyanion enolate that can be stereoselectively manipulated, and onto application of more recently developed olefin metathesis chemistry to prepare new CsA derivatives with unexpected biological activity.The myriad biological activities of CsA and its synthetic derivatives have inspired the development of new approaches to modify the CsA ring. In turn, these new CsA derivatives have served as tools in the discovery of new roles for cyclophilins.This review provides information on the types of cyclosporin derivatives that are available to the many biologists working in this field, and should be of value to the medicinal chemist trying to discover drugs based on CsA. This article is part of a Special Issue entitled Proline-directed foldases: Cell signaling catalysts and drug targets. Since its isolation in 1970, and discovery of its potent inhibitory activity on T-cell proliferation, cyclosporin A (CsA) has been shown to play a significant role in diverse fields of biology. Furthermore, chemical modification of CsA has led to analogs with distinct biological activities associated with its protein receptor family, cyclophilins. This review systematically collates the synthetic chemistry performed at each of the eleven amino acids, and provides examples of the utility of such transformations. The various modifications of CsA are traced from early, modest chemistry performed at the unique Bmt residue, through the remarkable use of a polyanion enolate that can be stereoselectively manipulated, and onto application of more recently developed olefin metathesis chemistry to prepare new CsA derivatives with unexpected biological activity. The myriad biological activities of CsA and its synthetic derivatives have inspired the development of new approaches to modify the CsA ring. In turn, these new CsA derivatives have served as tools in the discovery of new roles for cyclophilins. This review provides information on the types of cyclosporin derivatives that are available to the many biologists working in this field, and should be of value to the medicinal chemist trying to discover drugs based on CsA. This article is part of a Special Issue entitled Proline-directed foldases: Cell signaling catalysts and drug targets. •A review of cyclosporine compounds available for biological investigation•Overview of the biological activity of modified cyclosporins•A systematic review of chemistry applied to cyclosporine A Since its isolation in 1970, and discovery of its potent inhibitory activity on T-cell proliferation, cyclosporin A (CsA) has been shown to play a significant role in diverse fields of biology. Furthermore, chemical modification of CsA has led to analogs with distinct biological activities associated with its protein receptor family, cyclophilins.BACKGROUNDSince its isolation in 1970, and discovery of its potent inhibitory activity on T-cell proliferation, cyclosporin A (CsA) has been shown to play a significant role in diverse fields of biology. Furthermore, chemical modification of CsA has led to analogs with distinct biological activities associated with its protein receptor family, cyclophilins.This review systematically collates the synthetic chemistry performed at each of the eleven amino acids, and provides examples of the utility of such transformations. The various modifications of CsA are traced from early, modest chemistry performed at the unique Bmt residue, through the remarkable use of a polyanion enolate that can be stereoselectively manipulated, and onto application of more recently developed olefin metathesis chemistry to prepare new CsA derivatives with unexpected biological activity.SCOPE OF REVIEWThis review systematically collates the synthetic chemistry performed at each of the eleven amino acids, and provides examples of the utility of such transformations. The various modifications of CsA are traced from early, modest chemistry performed at the unique Bmt residue, through the remarkable use of a polyanion enolate that can be stereoselectively manipulated, and onto application of more recently developed olefin metathesis chemistry to prepare new CsA derivatives with unexpected biological activity.The myriad biological activities of CsA and its synthetic derivatives have inspired the development of new approaches to modify the CsA ring. In turn, these new CsA derivatives have served as tools in the discovery of new roles for cyclophilins.MAJOR CONCLUSIONSThe myriad biological activities of CsA and its synthetic derivatives have inspired the development of new approaches to modify the CsA ring. In turn, these new CsA derivatives have served as tools in the discovery of new roles for cyclophilins.This review provides information on the types of cyclosporin derivatives that are available to the many biologists working in this field, and should be of value to the medicinal chemist trying to discover drugs based on CsA. This article is part of a Special Issue entitled Proline-directed foldases: Cell signaling catalysts and drug targets.GENERAL SIGNIFICANCEThis review provides information on the types of cyclosporin derivatives that are available to the many biologists working in this field, and should be of value to the medicinal chemist trying to discover drugs based on CsA. This article is part of a Special Issue entitled Proline-directed foldases: Cell signaling catalysts and drug targets. Since its isolation in 1970, and discovery of its potent inhibitory activity on T-cell proliferation, cyclosporin A (CsA) has been shown to play a significant role in diverse fields of biology. Furthermore, chemical modification of CsA has led to analogs with distinct biological activities associated with its protein receptor family, cyclophilins. This review systematically collates the synthetic chemistry performed at each of the eleven amino acids, and provides examples of the utility of such transformations. The various modifications of CsA are traced from early, modest chemistry performed at the unique Bmt residue, through the remarkable use of a polyanion enolate that can be stereoselectively manipulated, and onto application of more recently developed olefin metathesis chemistry to prepare new CsA derivatives with unexpected biological activity. The myriad biological activities of CsA and its synthetic derivatives have inspired the development of new approaches to modify the CsA ring. In turn, these new CsA derivatives have served as tools in the discovery of new roles for cyclophilins. This review provides information on the types of cyclosporin derivatives that are available to the many biologists working in this field, and should be of value to the medicinal chemist trying to discover drugs based on CsA. This article is part of a Special Issue entitled Proline-directed foldases: Cell signaling catalysts and drug targets. |
| Author | Peel, Michael Scribner, Andrew |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25707381$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0006-291X(03)01537-7 10.7164/antibiotics.45.133 10.1021/jm0109863 10.1021/jm00048a002 10.1126/science.8211144 10.1038/ki.1993.194 10.1016/S0960-894X(01)80127-X 10.1016/j.bmcl.2010.09.036 10.1016/0006-2952(92)90598-D 10.1002/(SICI)1099-1387(199901)5:1<56::AID-PSC186>3.0.CO;2-J 10.1074/jbc.M409178200 10.1111/j.1399-3011.2005.00234.x 10.1074/jbc.M304754200 10.1073/pnas.192206699 10.1016/j.ejpb.2004.07.002 10.1007/BF00928431 10.1002/(SICI)1099-1344(20000315)43:3<205::AID-JLCR303>3.0.CO;2-4 10.1002/oms.1210281214 10.1021/ol0258987 10.1002/hlca.19910740833 10.1016/j.ejmech.2011.09.019 10.1074/jbc.272.10.6647 10.1002/hlca.19910740121 10.1002/hlca.19770600513 10.1055/s-2004-815405 10.1111/j.1399-3011.2003.00111.x 10.1042/BJ20090332 10.1021/bc00013a005 10.1038/81359 10.1016/0960-894X(95)00553-6 10.1073/pnas.212504399 10.1097/00001813-199605000-00004 10.1002/hlca.19870700103 10.1002/anie.200600743 10.1097/00054725-199503000-00006 10.1016/0960-894X(95)00281-W 10.1002/hlca.19800630323 10.1002/cbic.201200621 10.7164/antibiotics.45.94 10.1016/j.bmcl.2004.06.028 10.1177/095632029400500507 10.1007/BF00806587 10.1016/0092-8674(91)90124-H 10.1016/S0968-0896(98)00126-6 10.1002/hlca.19760590509 10.1111/j.1399-3011.1997.tb00877.x 10.1016/S0040-4039(01)80693-6 10.1016/S0009-9120(98)00014-9 10.1021/ja9636146 10.1016/j.bmc.2005.02.049 10.2340/00015555-0939 10.4049/jimmunol.1001707 10.7164/antibiotics.42.591 10.1016/S1074-5521(96)90249-5 10.7164/antibiotics.49.781 10.1002/jms.163 10.1016/S0040-4039(00)78250-5 10.1002/hlca.19940770129 10.1016/0031-9422(94)00711-2 10.1021/jo00113a046 10.1007/s10863-009-9206-x 10.1021/jo00296a061 10.1016/j.ejps.2005.05.003 10.1002/anie.200904529 10.1016/j.tet.2004.06.043 10.1002/hlca.19820650538 10.1016/S0960-894X(01)80716-2 10.1007/BF02980167 10.3390/v2081621 10.1016/S0021-9258(17)36774-1 10.1021/jo00035a027 10.1038/nchembio.214 10.1111/j.1749-6632.1993.tb22937.x 10.1021/ml1001272 10.1055/s-1994-22863 10.1002/cbic.200400020 10.2165/00126839-200708020-00005 10.1021/jo00120a034 10.1002/hlca.19760590412 10.1002/hlca.19930760415 10.1021/jm4007577 10.1021/jm00011a004 10.1006/bioo.1997.1058 10.1002/1521-3765(20001201)6:23<4358::AID-CHEM4358>3.0.CO;2-W 10.1021/jm00076a002 10.1021/bc000080w 10.1016/j.jchromb.2007.01.039 10.1021/jm025595i 10.1002/anie.198816241 10.1016/S0040-4020(03)00770-1 10.1021/jm010987v 10.1021/jo00055a020 10.1201/b14856-10 10.1093/clinchem/32.3.492 10.1084/jem.173.3.619 10.1002/jlcr.827 10.1021/bi9007287 10.1002/hlca.201000175 10.1002/jps.2600800416 10.1002/hlca.19850680319 10.1016/0003-2697(92)90579-V 10.1021/bc990098a 10.1016/0167-5699(92)90111-J 10.1002/cbic.200400383 10.1016/S0968-0896(96)00204-0 10.1002/hlca.19770600414 10.1111/j.1365-2133.2005.06563.x 10.1089/10807680151125537 10.1021/jm500862r 10.1021/ol062045w 10.1016/j.yjmcc.2009.03.006 10.1016/S0040-4039(00)01267-3 10.1263/jbb.99.390 10.1021/jo00103a015 10.1016/j.mito.2010.12.012 10.1016/j.bmcl.2003.09.042 10.1016/j.ab.2006.04.040 10.1016/0960-894X(95)00454-2 10.1016/j.bmcl.2013.05.101 10.2217/17460794.2.1.65 10.1002/anie.198500773 10.1016/S0021-9258(18)45369-0 10.1021/jm500223x 10.1021/op0501592 |
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| Keywords | Cyclic peptide Cyclosporine Cyclophilin Semi-synthesis |
| Language | English |
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| References | Jin, Harrison (bb0160) 2002; 99 M. Neya, S. Yoshimura, K. Kamijyo, T. Makino, M. Yasuda, T. Yamanaka, E. Tsujii, Y. Yamagishi, New cyclic peptide compounds, WO 2007049803 A1, 2007. K. Li, A. Mamai, M.R. Peel, Novel macrocyclic peptides, analogs of cyclosporin A, their preparation and their use in the treatment of HCV infections, US 20090312300 A1, 2009. Naldi, Griffiths (bb0110) 2005; 152 Peel, Scribner (bb0200) 2013; 23 J. Long, Y.S. Or, X. Gao, G. Wang, Preparation of cyclosporin analogs for treatment of diseases, US 20110008285 A1, 2011. Loor, Tiberghien, Wenandy, Didier, Traber (bb0085) 2002; 45 R. Wenger, M. Mutter, A. Hamel, F. Hubler, Cyclic undecapeptide pro-drugs and uses thereof, US 6995139 B2, 2006. M. Evers, S. Mignani, J.-C. Carry, B. Filoche, G. Bashiardes, C. Bensoussan, J.-C. Gueguen, J.-C. Barriere, Cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them, US 5977067, 1999. cyclosporin for the treatment of hepatitis C infection and pharmaceutical composition comprising said [D-MeAla] Y. Cheng, W. Zheng, L. He, L. Xiao, Preparation of derivatives of cyclosporin C and D, CN 101041689 A, 2007. Y.S. Or, I.J. Kim, G. Wang, J. Long, Preparation of cyclosporin analogs as antiviral agents, US 20110206637 A1 (2011). K. Li, D.R. Houck, C.O. Ogbu, M.R. Peel, A.W. Scribner, Derivatives of cyclosporin A, WO 2010076329 A1, 2010. Z. Su, Z. Long, Z. Huang, S. Yang, Novel cyclosporin derivatives for the treatment and prevention of a viral infection, WO 2012075494 A1, 2012. D.R. Houck, K. Li, Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection, WO 2007041631 A1, 2007. Eberle, Hiestand, Jutzi-Eme, Nuninger, Zihlmann (bb1165) 1995; 38 Eberle, Nuninger, Weber (bb0415) 1995; 60 S.N. Kim, H.J. Ahn, M.K. Kim, J.I. Kim, J.H. Kim, C.W. Lee, M.H. Lee, C.D. Kim, H.S. Cho, H.S. Kim, M.H. Jung, S.J. Kim, Noniummunosuppressive cyclosporin A derivative for hair growth, WO 2001035913 A1, 2001. Y.S. Or, T. Lazarova, J.S.-H. Chen, Preparation of cyclosporins for the treatment of immune disorders, US 20040110666 A1, 2004. D.F. Woodward, M.E. Garst, Cyclosporin derivatives for enhancing the growth of hair, WO 2010138422 A1, 2010. Traber, Kuhn, Loosli, Pache, von Wartburg (bb0095) 1977; 60 D. Selwood, M. Crompton, Cyclosporin-mitochondrial targeting group conjugates useful in the treatment of ischaemia/reperfusion injury and neurodegenerative diseases, GB 2472138, 2011. Billich, Vyplel, Grassberger, Schmook, Steck, Stuetz (bb0360) 2005; 13 Eberle, Jutzi-Eme, Nuninger (bb1030) 1994; 59 Huai, Kim, Liu, Zhao, Mondragon, Liu, Ke (bb0150) 2002; 99 Liu, Jiang, Richardson, Reddy, Johnson, Kati (bb0280) 2006; 356 Falck, Guldseth, Aasberg, Midtvedt, Reubsaet (bb1035) 2007; 852 A. Ruegger, M. Kuhn, Cyclosporin C derivatives, DE 2648121 A1, 1977. G. Wang, Y.S. Or, J. Long, X. Gao, Preparation of proline substituted cyclosporin analogs for treatment of diseases, US 20110008286 A1, 2011. Rai, Singh, Shukla, Sundar, Jha (bb0135) 2001; 49 Seebach, Kimmerlin, Sebesta, Campo, Beck (bb0730) 2004; 60 Hensens, White, Goegelman, Inamine, Patchett (bb1270) 1992; 45 Cho, Chung (bb0345) 2004; 24 P. Mouchet, A.R. Rees, E. Elmer, M.F. Keep, Composition for transporting cyclosporin derivatives through the blood brain barrier, WO 2003070755 A2, 2003. Zhang, Erdmann, Baumgrass, Schutkowski, Fischer (bb1155) 2005; 280 Belshaw, Spencer, Crabtree, Schreiber (bb0680) 1996; 3 Jegorov, Matha, Sedmera, Havlicek, Stuchlik, Seidel, Simek (bb0075) 1995; 38 P. Scalfaro, J.-M. Dumont, G. Vuagniaux, R.-Y. Mauvernay, Use of [D-MeAla] Hubler, Ruckle, Patiny, Muamba, Guichou, Mutter, Wenger (bb0950) 2000; 41 F. Striggow, W. Schmidt, G. Fischer, M. Theuerkorn, M. Malesevic, M. Weiwad, Compounds for the treatment of neurodegenerative disorders, EP 2705856, 2014. Loosli, Kessler, Oschkinat, Weber, Petcher, Widmer (bb0020) 1985; 68 Alberg, Schreiber (bb1125) 1993; 262 Hasumi, Nishikawa, Ohtani (bb0060) 1994; 34 Maeng, Yang, Manning, Masih, Cao, Pattamana, Bois, Molino (bb0295) 2012 M.K. Eberle, Preparation of cyclosporin analogs as drugs, EP 414632 A2, 1991. Papageorgiou, Kallen, France, French (bb0050) 1997; 5 M. Kuhn, A. Ruegger, Cyclosporin C and dihydrocyclosporin C, US 4210581 A, 1980. K. Li, A. Mamai, M.R. Peel, Cyclosporin analogs and their use in the treatment of HCV infections, WO 2009148615 A1, 2009. D. Davalian, M.H. Beresini, S. Alexander, M.W.-L. Hu, E.F. Ullman, Cyclosporin assay and kit, US 6,190,873 B1, 2001. Ryffel, Woerly, Quesniaux, Husi, Foxwell (bb1215) 1992; 43 J.-M. Adam, M. Abel, S. Jayaraman, Process for preparation of cyclosporin A analogs, WO 2004089960 A2, 2004. Ruckle, Dubray, Hubler, Mutter (bb0965) 1999; 5 K. Konno, T. Seto, H. Yoshifusa, Y. Ezure, Preparation of cyclosporin phosphate derivatives as immunosuppressants, WO 9711092, 1997. Z. Su, Z. Long, Z. Huang, S. Yang, Preparation of novel cyclosporin derivatives for the treatment and prevention of especially a viral infection, US 20130210704 A1, 2013. Zhang, Erdmann, Fischer (bb1190) 2009; 5 R. Wenger, M. Mutter, A. Hamel, F. Hubler, Preparation of cyclic undecapeptides for use as prodrugs, WO 2002085928 A2, 2002. Traber, Kobel, Loosli, Senn, Rosenwirth, Lawen (bb1055) 1994; 5 V.R. Chandran, Preparation of amino acid derivatives with high therapeutic index, US 20060241017 A1, 2006. Eberle, Nuninger (bb0390) 1994; 35 E. Ellmerer-Mueller, D. Brossner, N. Maslouh, H.-D. Ambrosi, G. Jas, Preparation of novel cyclosporins, WO 9965933 A1, 1999. Traber, Hofmann, Loosli, Ponelle, von Wartburg (bb0105) 1987; 70 Z. Su, Z. Long, Z. Huang, S. Yang, Novel cyclosporin derivatives for the treatment and prevention of a viral infection, WO 2012021796 A2, 2012. G. Fischer, Y. Zhang, R. Baumgrass, F. Erdmann, D-Ser Hamel, Hubler, Carrupt, Wenger, Mutter (bb0320) 2004; 63 Smulik, Diver, Pan, Liu (bb0585) 2002; 4 Evers, Barriere, Bashiardes, Bousseau, Carry, Dereu, Filoche, Henin, Sable, Vuilhorgne, Mignani (bb0895) 2003; 13 X. Gao, Y.S. Or, G. Wang, J. Long, Preparation of cyclosporin analogs for treatment of diseases, US 20110008284 A1, 2011. Kuzmic, Moss, Kofron, Rich (bb1235) 1992; 205 M.E. Garst, M.E. Stern, Cyclosporin derivatives for treating inflammatory diseases and conditions, WO 2010138423 A1, 2010. Eberle, Keese (bb1120) 2010; 93 Sigal, Dumont, Durette, Siekierka, Peterson, Rich, Dunlap, Staruch, Melino, Koprak, Williams, Witzel, Pisano (bb0445) 1991; 173 Anon. (bb0545) 2007; 8 Malesevic, Kuhling, Erdmann, Balsley, Bukrinsky, Constant, Fischer (bb1205) 2010; 49 J. Rosenthaler, R. Wenger, P.E. Ball, M.H. Schreier, V. Quesniaux, Monoclonal antibodies to cyclosporins, WO 8602080 A1, 1986. Jegorov, Havlicek, Sedmera (bb0420) 1996; 10 F. Erdmann, Y. Zhang, G. Fischer, Reversibly light-switchable drug-conjugates, EP 2116263 A1, 2009. K. Li, Preparation of cyclosporin derivatives, WO 2008143996 A1, 2008. Schreiber, Crabtree (bb0180) 1992; 13 G. Amouret, A. Guerreiro, C. Viskov, S. Mignani, M. Evers, J.-C. Barriere, G. Bashiardes, J.-C. Carry, B. Filoche, Preparation of cyclosporins modified in position 3 via polyanions and coupling reaction, WO 9932512 A1, 1999. P. Scalfaro, J.-M. Dumont, G. Vuagniaux, R.-Y. Mauvernay, Use of selected cyclosporins for the treatment of hepatitis C infection, US 7439227 B2, 2008. R.P. Traber, M. Kuhn, Dihydroisocyclosporin D derivatives, CH 630061 A5, 1982. G. Amouret, A. Guerreiro, C. Viskov, S. Mignani, M. Evers, J.-C. Barriere, G. Bashiardes, J.-C. Carry, B. Filoche, Novel method for preparing cyclosporin derivatives, EP 1040121 B1, 1999. Di Lisa, Bernardi (bb0215) 2009; 46 Gaali, Kozany, Hoogeland, Klein, Hausch (bb0635) 2010; 1 G. Fischer, M. Malesevic, F. Erdmann, J. Kuehling, M. Bukrinsky, S. Constant, G. Ruehter, P. Nussbaumer, K. Dinkel, Synthesis of cylcosporin derivatives for use in diagnosis or treatment of disease, plant protection, or pest control, DE 102011111991 A1, 2013 Schreiber (bb1135) 1998; 6 Traber, Loosli, Hofmann, Kuhn, von Wartburg (bb0100) 1982; 65 Lallemand, Felt-Baeyens, Rudaz, Hamel, Hubler, Wenger, Mutter, Besseghir, Gurny (bb0340) 2005; 59 Z. Su, Z. Long, Z. Huang, S. Yang, Preparation of novel cyclosporin derivatives for the treatment and prevention of a viral infection, WO 2013028615 A2, 2013. Tindall, Phillips, Rollins, Wells, Hall (bb0130) 1993; 681 Wenger, The Chemistry of Cyclosporine (bb0235) 1996 Schramm, Fricker, Wenger, Miller (bb1220) 1995; 268 A. Hegmans, B.W. Fenske, D.J. Trepanier, M.D. Abel, S. Sugiyama, D.R. Ure, Preparation of cyclosporin A analogs modified at amino acid 1 and 3 as cyclophilin ligands with reduced immunosuppressivity for treating cyclophilin mediated diseases, WO 2012079172 A1, 2012. S.-N. Kim, H.-J. Ahn, C.-W. Lee, M.-H. Lee, J.-H. Kim, J.-I. Kim, S.-J. Kim, H.-S. Cho, H.-S. Lee, H.-K. Kim, Use of 3-position cyclosporin derivatives for hair growth, US 20030186857 A1, 2003. P. Bernardi, G. Vuagniaux, R. Crabble, Non-immunosuppressive cyclosporin for treatment of Ullrich congenital muscular dystrophy, WO 2008084368 A2, 2008. Malesevic, Gutknecht, Prell, Klein, Schumann, Nowak, Simon, Schiene-Fischer, Saalbach (bb0465) 2013; 56 Traber (bb0090) 1977; 60 E. Ellmerer-Mueller, D. Brossner, N. Maslouh, H.-D. Ambrosi, G. Jas, G. Fischer, Novel cyclosporins, EP 1086124 B1, 1999. Kulkarni (bb0115) 2001; 17 Petcher, Weber, Ruegger (bb0025) 1976; 59 Lamos, Krusemark, McGee, Scalf, Smith, Belshaw (bb0640) 2006; 45 Liu, Farner, Lane, Friedman, Weissman, Schreiber (bb0175) 1991; 66 W.R. Carling, D.A. Scowen, M.E. Garst, M.E. Stern, C.S. Schaumburg, Cyclosporin analogs, WO 2012051193 A1, 2012. Sandborn (bb0145) 1995; 1 Y.F. Zheng, D.K. Vickery, S.C. Swann, Methods for detection of cyclosporin A, WO 2009088694 A1, 2009. Wenger (bb0035) 1985; 24 Lazarova, Chen, Hamann, Kang, Homuth-Trombino, Han, Hoffmann, McClure, Eckstein, Or (bb0590) 2003; 46 Prell, Kahlert, Ruecknagel, Malesevic, Fischer (bb0690) 2013; 14 C.O. Ogbu, T.E. Richardson, Cyclosporine analogues as antiviral agents, WO 2011082289 A1, 2011. Belshaw, Meyer, Johnson, Romo, Ikeda, Oliyai (10.1016/j.bbagen.2015.02.008_bb0220) 1995; 5 10.1016/j.bbagen.2015.02.008_bb1090 Lallemand (10.1016/j.bbagen.2015.02.008_bb0340) 2005; 59 10.1016/j.bbagen.2015.02.008_bb0790 10.1016/j.bbagen.2015.02.008_bb0670 10.1016/j.bbagen.2015.02.008_bb0550 10.1016/j.bbagen.2015.02.008_bb1085 10.1016/j.bbagen.2015.02.008_bb0435 Traber (10.1016/j.bbagen.2015.02.008_bb0105) 1987; 70 Kuhnt (10.1016/j.bbagen.2015.02.008_bb1040) 1996; 49 10.1016/j.bbagen.2015.02.008_bb0310 Park (10.1016/j.bbagen.2015.02.008_bb0450) 1989; 30 Levitsky (10.1016/j.bbagen.2015.02.008_bb0555) 2005; 6 10.1016/j.bbagen.2015.02.008_bb0795 Seebach (10.1016/j.bbagen.2015.02.008_bb1025) 1991; 74 Peel (10.1016/j.bbagen.2015.02.008_bb0200) 2013; 23 Jegorov (10.1016/j.bbagen.2015.02.008_bb0255) 2001; 36 Hubler (10.1016/j.bbagen.2015.02.008_bb0950) 2000; 41 Eberle (10.1016/j.bbagen.2015.02.008_bb0380) 1995; 5 Gaali (10.1016/j.bbagen.2015.02.008_bb0635) 2010; 1 Schreiber (10.1016/j.bbagen.2015.02.008_bb0180) 1992; 13 Malouitre (10.1016/j.bbagen.2015.02.008_bb0780) 2010; 425 10.1016/j.bbagen.2015.02.008_bb1095 10.1016/j.bbagen.2015.02.008_bb0325 Traber (10.1016/j.bbagen.2015.02.008_bb0095) 1977; 60 Shevchenko (10.1016/j.bbagen.2015.02.008_bb0645) 2004; 47 10.1016/j.bbagen.2015.02.008_bb0685 Schumann (10.1016/j.bbagen.2015.02.008_bb0290) 2011; 46 10.1016/j.bbagen.2015.02.008_bb0565 Wenger (10.1016/j.bbagen.2015.02.008_bb1280) 1988; 20 Seebach (10.1016/j.bbagen.2015.02.008_bb0730) 2004; 60 10.1016/j.bbagen.2015.02.008_bb0330 Papageorgiou (10.1016/j.bbagen.2015.02.008_bb0980) 1994; 4 Fu (10.1016/j.bbagen.2015.02.008_bb1020) 2014; 57 Schramm (10.1016/j.bbagen.2015.02.008_bb1220) 1995; 268 Gizatullina (10.1016/j.bbagen.2015.02.008_bb1180) 2011; 11 Eberle (10.1016/j.bbagen.2015.02.008_bb0390) 1994; 35 10.1016/j.bbagen.2015.02.008_bb0695 10.1016/j.bbagen.2015.02.008_bb0455 Didier (10.1016/j.bbagen.2015.02.008_bb1225) 1996; 7 Wei (10.1016/j.bbagen.2015.02.008_bb0490) 2004; 14 10.1016/j.bbagen.2015.02.008_bb0905 Schreiber (10.1016/j.bbagen.2015.02.008_bb1135) 1998; 6 Lazarova (10.1016/j.bbagen.2015.02.008_bb0590) 2003; 46 Cho (10.1016/j.bbagen.2015.02.008_bb0345) 2004; 24 Gfeller (10.1016/j.bbagen.2015.02.008_bb0395) 1980; 63 10.1016/j.bbagen.2015.02.008_bb0460 Seebach (10.1016/j.bbagen.2015.02.008_bb0040) 1991; 74 Fois (10.1016/j.bbagen.2015.02.008_bb0260) 1991; 80 Loor (10.1016/j.bbagen.2015.02.008_bb0080) 2002; 45 10.1016/j.bbagen.2015.02.008_bb0580 Papageorgiou (10.1016/j.bbagen.2015.02.008_bb0975) 1994; 37 10.1016/j.bbagen.2015.02.008_bb0900 Ohta (10.1016/j.bbagen.2015.02.008_bb1295) 2005; 99 Arnoldi (10.1016/j.bbagen.2015.02.008_bb0225) 1997; 25 Jegorov (10.1016/j.bbagen.2015.02.008_bb0075) 1995; 38 Traber (10.1016/j.bbagen.2015.02.008_bb0070) 1997; 82 Seebach (10.1016/j.bbagen.2015.02.008_bb0055) 1994; 77 Jin (10.1016/j.bbagen.2015.02.008_bb0160) 2002; 99 Yang (10.1016/j.bbagen.2015.02.008_bb0575) 2009 10.1016/j.bbagen.2015.02.008_bb0915 Hamel (10.1016/j.bbagen.2015.02.008_bb0320) 2004; 63 Hensens (10.1016/j.bbagen.2015.02.008_bb1270) 1992; 45 Malesevic (10.1016/j.bbagen.2015.02.008_bb1205) 2010; 49 Havlicek (10.1016/j.bbagen.2015.02.008_bb0230) 1993; 28 Alberg (10.1016/j.bbagen.2015.02.008_bb1125) 1993; 262 10.1016/j.bbagen.2015.02.008_bb0350 10.1016/j.bbagen.2015.02.008_bb1200 10.1016/j.bbagen.2015.02.008_bb0470 10.1016/j.bbagen.2015.02.008_bb0910 10.1016/j.bbagen.2015.02.008_bb0475 Burtscher (10.1016/j.bbagen.2015.02.008_bb0400) 2000; 43 Papageorgiou (10.1016/j.bbagen.2015.02.008_bb0760) 1996; 6 10.1016/j.bbagen.2015.02.008_bb0925 10.1016/j.bbagen.2015.02.008_bb0805 Liu (10.1016/j.bbagen.2015.02.008_bb0175) 1991; 66 10.1016/j.bbagen.2015.02.008_bb0485 10.1016/j.bbagen.2015.02.008_bb0480 Sandborn (10.1016/j.bbagen.2015.02.008_bb0145) 1995; 1 Maeng (10.1016/j.bbagen.2015.02.008_bb0295) 2012 10.1016/j.bbagen.2015.02.008_bb0920 10.1016/j.bbagen.2015.02.008_bb0800 10.1016/j.bbagen.2015.02.008_bb0365 10.1016/j.bbagen.2015.02.008_bb0245 Eberle (10.1016/j.bbagen.2015.02.008_bb0270) 1993; 58 Boesch (10.1016/j.bbagen.2015.02.008_bb0410) 1991; 51 Rai (10.1016/j.bbagen.2015.02.008_bb0135) 2001; 49 Sigal (10.1016/j.bbagen.2015.02.008_bb0445) 1991; 173 10.1016/j.bbagen.2015.02.008_bb0935 10.1016/j.bbagen.2015.02.008_bb0815 Bernard (10.1016/j.bbagen.2015.02.008_bb0010) 1986; 38 10.1016/j.bbagen.2015.02.008_bb0495 Hasumi (10.1016/j.bbagen.2015.02.008_bb0060) 1994; 34 10.1016/j.bbagen.2015.02.008_bb0370 10.1016/j.bbagen.2015.02.008_bb0250 Keller (10.1016/j.bbagen.2015.02.008_bb0710) 2000; 6 10.1016/j.bbagen.2015.02.008_bb0810 Wenger (10.1016/j.bbagen.2015.02.008_bb0235) 1996 Malesevic (10.1016/j.bbagen.2015.02.008_bb0465) 2013; 56 Kallen (10.1016/j.bbagen.2015.02.008_bb0065) 1997; vol. 7 10.1016/j.bbagen.2015.02.008_bb1105 Eberle (10.1016/j.bbagen.2015.02.008_bb1120) 2010; 93 10.1016/j.bbagen.2015.02.008_bb0945 10.1016/j.bbagen.2015.02.008_bb0825 Liu (10.1016/j.bbagen.2015.02.008_bb0425) 1998; 31 Huai (10.1016/j.bbagen.2015.02.008_bb0150) 2002; 99 10.1016/j.bbagen.2015.02.008_bb1110 10.1016/j.bbagen.2015.02.008_bb1230 10.1016/j.bbagen.2015.02.008_bb0385 10.1016/j.bbagen.2015.02.008_bb0265 Rothbard (10.1016/j.bbagen.2015.02.008_bb0355) 2000; 6 Billich (10.1016/j.bbagen.2015.02.008_bb0360) 2005; 13 Smulik (10.1016/j.bbagen.2015.02.008_bb0585) 2002; 4 10.1016/j.bbagen.2015.02.008_bb0820 Scribner (10.1016/j.bbagen.2015.02.008_bb0285) 2010; 20 10.1016/j.bbagen.2015.02.008_bb0940 10.1016/j.bbagen.2015.02.008_bb1115 Carry (10.1016/j.bbagen.2015.02.008_bb0275) 2004 10.1016/j.bbagen.2015.02.008_bb0835 10.1016/j.bbagen.2015.02.008_bb0715 Billich (10.1016/j.bbagen.2015.02.008_bb1145) 1987; 262 Paprica (10.1016/j.bbagen.2015.02.008_bb0430) 1992; 3 Eberle (10.1016/j.bbagen.2015.02.008_bb1240) 1995; 60 10.1016/j.bbagen.2015.02.008_bb1000 Papageorgiou (10.1016/j.bbagen.2015.02.008_bb0700) 1993; 3 Dreyfuss (10.1016/j.bbagen.2015.02.008_bb0005) 1976; 3 Eberle (10.1016/j.bbagen.2015.02.008_bb0675) 1992; 57 Ruegger (10.1016/j.bbagen.2015.02.008_bb0015) 1976; 59 Kulkarni (10.1016/j.bbagen.2015.02.008_bb0115) 2001; 17 Altman (10.1016/j.bbagen.2015.02.008_bb0125) 1999; 26 10.1016/j.bbagen.2015.02.008_bb0955 10.1016/j.bbagen.2015.02.008_bb1245 Liu (10.1016/j.bbagen.2015.02.008_bb0280) 2006; 356 Jegorov (10.1016/j.bbagen.2015.02.008_bb0420) 1996; 10 10.1016/j.bbagen.2015.02.008_bb0830 10.1016/j.bbagen.2015.02.008_bb1005 Zhou (10.1016/j.bbagen.2015.02.008_bb0595) 2006; 8 10.1016/j.bbagen.2015.02.008_bb0605 Patiny (10.1016/j.bbagen.2015.02.008_bb1100) 2003; 59 Zhang (10.1016/j.bbagen.2015.02.008_bb0930) 2004; 5 10.1016/j.bbagen.2015.02.008_bb1010 10.1016/j.bbagen.2015.02.008_bb1255 10.1016/j.bbagen.2015.02.008_bb1250 10.1016/j.bbagen.2015.02.008_bb0600 10.1016/j.bbagen.2015.02.008_bb0845 10.1016/j.bbagen.2015.02.008_bb1015 10.1016/j.bbagen.2015.02.008_bb0960 10.1016/j.bbagen.2015.02.008_bb0840 Grote (10.1016/j.bbagen.2015.02.008_bb0375) 2005; 9 10.1016/j.bbagen.2015.02.008_bb0720 Ke (10.1016/j.bbagen.2015.02.008_bb0155) 2003; 311 10.1016/j.bbagen.2015.02.008_bb0615 Eberle (10.1016/j.bbagen.2015.02.008_bb1165) 1995; 38 Zhang (10.1016/j.bbagen.2015.02.008_bb1155) 2005; 280 Lallemand (10.1016/j.bbagen.2015.02.008_bb0335) 2005; 26 10.1016/j.bbagen.2015.02.008_bb1260 10.1016/j.bbagen.2015.02.008_bb1140 10.1016/j.bbagen.2015.02.008_bb0855 El Tayar (10.1016/j.bbagen.2015.02.008_bb0030) 1993; 36 10.1016/j.bbagen.2015.02.008_bb0735 Boubouka (10.1016/j.bbagen.2015.02.008_bb0120) 2011; 91 10.1016/j.bbagen.2015.02.008_bb0970 10.1016/j.bbagen.2015.02.008_bb0850 10.1016/j.bbagen.2015.02.008_bb0610 Traber (10.1016/j.bbagen.2015.02.008_bb0100) 1982; 65 10.1016/j.bbagen.2015.02.008_bb0505 Lamos (10.1016/j.bbagen.2015.02.008_bb0640) 2006; 45 Traber (10.1016/j.bbagen.2015.02.008_bb1055) 1994; 5 10.1016/j.bbagen.2015.02.008_bb1275 Ruckle (10.1016/j.bbagen.2015.02.008_bb0965) 1999; 5 10.1016/j.bbagen.2015.02.008_bb1150 Demeule (10.1016/j.bbagen.2015.02.008_bb0775) 1997; 272 10.1016/j.bbagen.2015.02.008_bb0985 Traber (10.1016/j.bbagen.2015.02.008_bb0090) 1977; 60 10.1016/j.bbagen.2015.02.008_bb0865 10.1016/j.bbagen.2015.02.008_bb0745 10.1016/j.bbagen.2015.02.008_bb0625 10.1016/j.bbagen.2015.02.008_bb0860 10.1016/j.bbagen.2015.02.008_bb0740 10.1016/j.bbagen.2015.02.008_bb0620 10.1016/j.bbagen.2015.02.008_bb0500 Tang (10.1016/j.bbagen.2015.02.008_bb0190) 2010; 2 Zhang (10.1016/j.bbagen.2015.02.008_bb1190) 2009; 5 Kuzmic (10.1016/j.bbagen.2015.02.008_bb1235) 1992; 205 10.1016/j.bbagen.2015.02.008_bb1170 10.1016/j.bbagen.2015.02.008_bb1290 Peel (10.1016/j.bbagen.2015.02.008_bb0205) 2013 Prell (10.1016/j.bbagen.2015.02.008_bb0690) 2013; 14 Colucci (10.1016/j.bbagen.2015.02.008_bb1285) 1990; 55 10.1016/j.bbagen.2015.02.008_bb0990 10.1016/j.bbagen.2015.02.008_bb0870 10.1016/j.bbagen.2015.02.008_bb1045 10.1016/j.bbagen.2015.02.008_bb1160 10.1016/j.bbagen.2015.02.008_bb0875 Ponticelli (10.1016/j.bbagen.2015.02.008_bb0140) 1993; 43 Belshaw (10.1016/j.bbagen.2015.02.008_bb0680) 1996; 3 10.1016/j.bbagen.2015.02.008_bb0755 10.1016/j.bbagen.2015.02.008_bb0515 10.1016/j.bbagen.2015.02.008_bb0750 10.1016/j.bbagen.2015.02.008_bb0630 Halestrap (10.1016/j.bbagen.2015.02.008_bb0210) 2009; 41 10.1016/j.bbagen.2015.02.008_bb0510 Tindall (10.1016/j.bbagen.2015.02.008_bb0130) 1993; 681 10.1016/j.bbagen.2015.02.008_bb0995 Falck (10.1016/j.bbagen.2015.02.008_bb1035) 2007; 852 Loor (10.1016/j.bbagen.2015.02.008_bb0085) 2002; 45 Hamel (10.1016/j.bbagen.2015.02.008_bb0315) 2005; 65 Belshaw (10.1016/j.bbagen.2015.02.008_bb1300) 1997; 119 10.1016/j.bbagen.2015.02.008_bb0880 10.1016/j.bbagen.2015.02.008_bb1050 Lu (10.1016/j.bbagen.2015.02.008_bb0440) 2000; 11 10.1016/j.bbagen.2015.02.008_bb0765 Wenger (10.1016/j.bbagen.2015.02.008_bb0035) 1985; 24 Eberle (10.1016/j.bbagen.2015.02.008_bb0415) 1995; 60 10.1016/j.bbagen.2015.02.008_bb0525 10.1016/j.bbagen.2015.02.008_bb0405 Seebach (10.1016/j.bbagen.2015.02.008_bb0725) 1988; 27 10.1016/j.bbagen.2015.02.008_bb0520 10.1016/j.bbagen.2015.02.008_bb0885 Sweeney (10.1016/j.bbagen.2015.02.008_bb0195) 2014; 57 Evers (10.1016/j.bbagen.2015.02.008_bb0895) 2003; 13 Baumgrass (10.1016/j.bbagen.2015.02.008_bb0165) 2004; 279 10.1016/j.bbagen.2015.02.008_bb1070 Eberle (10.1016/j.bbagen.2015.02.008_bb1030) 1994; 59 Wong (10.1016/j.bba |
| References_xml | – volume: 9 start-page: 822 year: 2005 end-page: 824 ident: bb0375 article-title: A practical method for the synthesis of a cyclosporine–fluorescein conjugate publication-title: Org. Process Res. Dev. – volume: 3 start-page: 2559 year: 1993 end-page: 2564 ident: bb0700 article-title: Derivatives of cyclosporin at position 2 as probes for cyclophilin publication-title: Bioorg. Med. Chem. Lett. – start-page: 63 year: 2012 end-page: 68 ident: bb0295 article-title: Organozirconium chemistry on cyclosporin: a novel process for the highly stereoselective synthesis of ( publication-title: Synthesis – reference: G. Wang, Y.S. Or, J. Long, X. Gao, Preparation of proline substituted cyclosporin analogs for treatment of diseases, US 20110008286 A1, 2011. – reference: J.B. Rothbard, P.A. Wender, P.L. McGrane, L.V.S. Sista, T. Kirschberg, Compositions and methods for enhancing drug delivery across and into ocular tissues, US 20030022831 A1, 2003. – reference: D. Selwood, M. Crompton, Cyclosporin-mitochondrial targeting group conjugates useful in the treatment of ischaemia/reperfusion injury and neurodegenerative diseases, GB 2472138, 2011. – volume: 60 start-page: 7455 year: 2004 end-page: 7506 ident: bb0730 article-title: How we drifted into peptide chemistry and where we have arrived at publication-title: Tetrahedron – reference: Z. Su, Z. Huang, Z. Long, S. Yang, Novel cyclosporin derivatives for the treatment and prevention of a viral infection, WO 2012009715 A2, 2012. – volume: 311 start-page: 1095 year: 2003 end-page: 1102 ident: bb0155 article-title: Structures of calcineurin and its complexes with immunophilins-immunosuppressants publication-title: Biochem. Biophys. Res. Commun. – reference: S.Y. Ko, H. Kobel, B. Besemer-Rosenwirth, D. Seebach, R.P. Traber, R. Wenger, P. Bollinger, Cyclosporins, US 5981479, 1999. – volume: 57 start-page: 2689 year: 1992 end-page: 2691 ident: bb0675 article-title: Synthesis of the main metabolite (OL-17) of cyclosporin A publication-title: J. Org. Chem. – volume: 7 start-page: 257 year: 1996 end-page: 265 ident: bb1225 article-title: Detection of P-glycoprotein expression by tumoral cells with NBDL-CsA, a fluorescent derivative of cyclosporin A publication-title: Anti-Cancer Drugs – reference: J.-M. Adam, M. Abel, S. Jayaraman, Process for preparation of cyclosporin A analogs, WO 2004089960 A2, 2004. – volume: 272 start-page: 6647 year: 1997 end-page: 6652 ident: bb0775 article-title: Molecular interactions of cyclosporin A with P-glycoprotein. Photolabeling with cyclosporin derivatives publication-title: J. Biol. Chem. – reference: A. Hegmans, B.W. Fenske, D.J. Trepanier, M.D. Abel, S. Sugiyama, D.R. Ure, Preparation of cyclosporin A analogs modified at amino acid 1 and 3 as cyclophilin ligands with reduced immunosuppressivity for treating cyclophilin mediated diseases, WO 2012079172 A1, 2012. – volume: 6 start-page: 1253 year: 2000 end-page: 1257 ident: bb0355 article-title: Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation publication-title: Nat. Med. – volume: 91 start-page: 50 year: 2011 end-page: 54 ident: bb0120 article-title: Treatment of autoimmune urticaria with low-dose cyclosporin A: a one-year follow-up publication-title: Acta Derm. Venereol. – reference: G. Fischer, M. Malesevic, F. Erdmann, J. Kuehling, M. Bukrinsky, S. Constant, Preparation and use of cyclosporin derivatives in the treatment of chronic inflammatory diseases, WO 2011020596 A2, 2011. – reference: D. Seebach, Cyclosporins, EP 194972 A2, 1986. – volume: 56 start-page: 7302 year: 2013 end-page: 7311 ident: bb0465 article-title: Anti-inflammatory effects of extracellular cyclosporins are exclusively mediated by CD147 publication-title: J. Med. Chem. – volume: 5 start-page: 1006 year: 2004 end-page: 1009 ident: bb0930 article-title: Branches on the α-C atom of cyclosporin A residue 3 result in direct calcineurin inhibition and rapid cyclophilin 18 binding publication-title: ChemBioChem – volume: 20 start-page: 6542 year: 2010 end-page: 6546 ident: bb0285 article-title: Synthesis and biological evaluation of [D-lysine] publication-title: Bioorg. Med. Chem. Lett. – volume: 77 start-page: 291 year: 1994 end-page: 305 ident: bb0055 article-title: Calorimetric measurements of the complexation of cyclosporin A, ascomycin, fujimycin, and rapamycin with lithium chloride and with an immunophilin publication-title: Helv. Chim. Acta – volume: 27 start-page: 1624 year: 1988 end-page: 1654 ident: bb0725 article-title: Structure and reactivity of lithium enolates. from pinacolone to selective publication-title: Angew. Chem. Int. Ed. Engl. – volume: 76 start-page: 1564 year: 1993 end-page: 1590 ident: bb0045 article-title: Modification of cyclosporin A (CS): generation of an enolate at the sarcosine residue and reactions with electrophiles publication-title: Helv. Chim. Acta – volume: 60 start-page: 1568 year: 1977 end-page: 1578 ident: bb0095 article-title: New cyclopeptides from publication-title: Helv. Chim. Acta – reference: D. Davalian, M.H. Beresini, S. Alexander, M.W. Hu, E.F. Ullman, Cyclosporin immunoassay and reagents, EP 487289 A2, 1992. – volume: 280 start-page: 4842 year: 2005 end-page: 4850 ident: bb1155 article-title: Unexpected side chain effects at residue 8 of cyclosporin A derivatives allow photoswitching of immunosuppression publication-title: J. Biol. Chem. – volume: 38 start-page: 1 year: 1986 end-page: 8 ident: bb0010 article-title: Ciclosporin. Forward publication-title: Prog. Allergy – reference: D.F. Woodward, M.E. Garst, Cyclosporin derivatives for enhancing the growth of hair, WO 2010138422 A1, 2010. – reference: K. Konno, T. Seto, H. Yoshifusa, Y. Ezure, Preparation of cyclosporin phosphate derivatives as immunosuppressants, WO 9711092, 1997. – volume: 6 start-page: 23 year: 1996 end-page: 26 ident: bb0760 article-title: Anti HIV-1 activity of a hydrophilic cyclosporin derivative with improved binding affinity to cyclophilin A publication-title: Bioorg. Med. Chem. Lett. – volume: 28 start-page: 1440 year: 1993 end-page: 1447 ident: bb0230 article-title: Sequencing of cyclosporins by fast atom bombardment and linked-scan mass spectrometry publication-title: Org. Mass Spectrom. – reference: G. Fischer, M. Malesevic, F. Erdmann, J. Kuehling, M. Bukrinsky, S. Constant, G. Ruehter, P. Nussbaumer, K. Dinkel, Synthesis of cylcosporin derivatives for use in diagnosis or treatment of disease, plant protection, or pest control, DE 102011111991 A1, 2013 – volume: 74 start-page: 197 year: 1991 end-page: 224 ident: bb0040 article-title: -Alkylation of peptides through polylithiated and LiCl-solvated derivatives containing sarcosine Li-enolate units publication-title: Helv. Chim. Acta – reference: Z. Su, Z. Long, Z. Huang, S. Yang, Preparation of novel cyclosporin derivatives for the treatment and prevention of especially a viral infection, US 20130210704 A1, 2013. – reference: P. Scalfaro, J.-M. Dumont, G. Vuagniaux, R.-Y. Mauvernay, Use of selected cyclosporins for the treatment of hepatitis C infection, US 7439227 B2, 2008. – reference: R. Wenger, M. Mutter, A. Hamel, F. Hubler, Cyclic undecapeptide pro-drugs and uses thereof, US 6995139 B2, 2006. – volume: 66 start-page: 807 year: 1991 end-page: 815 ident: bb0175 article-title: Calcineurin is a common target of cyclophilin–cyclosporin A and FKBP-FK506 complexes publication-title: Cell – reference: S. Naicker, R.W. Yatscoff, R.T. Foster, M. Abel, S. Jayaraman, H.-J. Mair, J.-M. Adam, B. Lohri, Synthesis of cyclosporin analogs, WO 2003033526 A2, 2003. – volume: 5 start-page: 1725 year: 1995 end-page: 1728 ident: bb0380 article-title: Modifications of the MeBmt side chain of cyclosporin A publication-title: Bioorg. Med. Chem. Lett. – volume: 51 start-page: 4226 year: 1991 end-page: 4233 ident: bb0410 article-title: In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833 publication-title: Cancer Res. – reference: D.R. Houck, Cyclosporin derivatives for the treatment and prevention of hepatitis C infection, WO 2007041632 A2, 2007. – reference: K. Li, A. Mamai, M.R. Peel, Cyclosporin analogs and their use in the treatment of HCV infections, WO 2009148615 A1, 2009. – volume: 10 start-page: 145 year: 1996 end-page: 151 ident: bb0420 article-title: An unusual side chain C–C cleavage at the MeBmt amino acid in cyclosporin A publication-title: Amino Acids – reference: M. Evers, S. Mignani, J.-C. Carry, B. Filoche, G. Bashiardes, C. Bensoussan, J.-C. Gueguen, J.-C. Barriere, Preparation of novel cyclosporin derivatives and pharmaceutical compositions, WO 9849193 A1, 1998. – reference: A.W. Scribner, D.R. Houck, Preparation of novel cyclic peptides for the treatment of hepatitis C virus, WO 2008069917 A2, 2008. – reference: R.P. Traber, M. Kuhn, Dihydrocyclosporin E derivatives, CH 630062 A5, 1982. – reference: C.O. Ogbu, T.E. Richardson, Cyclosporine analogues as antiviral agents, WO 2011082289 A1, 2011. – reference: J.-C. Barriere, J.-C. Carry, B. Filoche, M. Evers, G. Bashiardes, S. Mignani, J.P. Leconte, Preparation of cyclosporin derivatives and their pharmaceutical compositions, FR 2757522 A1, 1998. – volume: 13 start-page: 4415 year: 2003 end-page: 4419 ident: bb0895 article-title: Synthesis of non-immunosuppressive cyclophilin-binding cyclosporin A derivatives as potential anti-HIV-1 drugs publication-title: Bioorg. Med. Chem. Lett. – reference: P. Bernardi, G. Vuagniaux, R. Crabble, Non-immunosuppressive cyclosporin for treatment of Ullrich congenital muscular dystrophy, WO 2008084368 A2, 2008. – volume: 45 start-page: 4598 year: 2002 end-page: 4612 ident: bb0080 article-title: Cyclosporins: structure–activity relationships for the inhibition of the human publication-title: J. Med. Chem. – volume: 8 start-page: 5247 year: 2006 end-page: 5250 ident: bb0595 article-title: Synthesis, characterization, and utility of thermoresponsive natural/unnatural product macroligands for affinity chromatography publication-title: Org. Lett. – volume: 59 start-page: 5241 year: 2003 end-page: 5249 ident: bb1100 article-title: Synthesis and characterization of constrained cyclosporin A derivatives containing a psuedo-proline group publication-title: Tetrahedron – volume: 26 start-page: 124 year: 2005 end-page: 129 ident: bb0335 article-title: A water-soluble prodrug of cyclosporine A for ocular application: a stability study publication-title: Eur. J. Pharm. Sci. – volume: 5 start-page: 331 year: 1994 end-page: 339 ident: bb1055 article-title: [MeIle publication-title: Antivir. Chem. Chemother. – volume: 5 start-page: 724 year: 2009 end-page: 726 ident: bb1190 article-title: Augmented photoswitching modulates immune signaling publication-title: Nat. Chem. Biol. – reference: B.F. Molino, Z. Yang, J.-H. Maeng, D.D. Manning, Novel processes for stereoselective synthesis of trans ISATX247, WO 2006014872 A2, 2006. – volume: 49 start-page: 213 year: 2010 end-page: 215 ident: bb1205 article-title: A cyclosporin derivative discriminates between extracellular and intracellular cyclophilins publication-title: Angew. Chem. Int. Ed. Engl. – volume: 26 start-page: 2102 year: 1999 end-page: 2109 ident: bb0125 article-title: Cyclosporine A in rheumatoid arthritis: randomized, placebo controlled dose finding study publication-title: J. Rheumatol. – reference: M. Mutter, R.M. Wenger, J.-F. Guichou, M. Keller, T. Ruckle, T. Woehr, Preparation of cyclosporin derivatives as cis/trans isomerase inhibitors, WO 2000046239 A1, 2000. – volume: 5 start-page: 2735 year: 1995 end-page: 2740 ident: bb0220 article-title: Structural factors affecting the kinetics of O, N-acyl transfer in potential O-peptide prodrugs publication-title: Bioorg. Med. Chem. Lett. – reference: B.F. Molino, S.N. Haydar, Z. Yang, P.C. Michels, M.S. Hemenway, J.O. Rich, Y. Khmelnitsky, Preparation of novel cyclosporins, WO 2004082629 A2, 2004. – volume: 14 start-page: 63 year: 2013 end-page: 65 ident: bb0690 article-title: Fine tuning the inhibition profile of cyclosporine A by derivitization of the MeBmt residue publication-title: Chembiochem – volume: 17 start-page: 181 year: 2001 end-page: 187 ident: bb0115 article-title: Review: uveitis and immunosuppressive drugs publication-title: J. Ocul. Pharmacol. Ther. – reference: R. Wenger, M. Mutter, A. Hamel, F. Hubler, Preparation of cyclic undecapeptides for use as prodrugs, WO 2002085928 A2, 2002. – reference: T. Oki, K. Imano, T. Seto, T. Ueda, Method for phosphorylation of cyclosporins, JP 10279596 A, 1998. – volume: 1 start-page: 536 year: 2010 end-page: 539 ident: bb0635 article-title: Facile synthesis of a fluorescent cyclosporin A analogue to study cyclophilin 40 and cyclophilin 18 ligands publication-title: ACS Med. Chem. Lett. – reference: F. Erdmann, Y. Zhang, G. Fischer, Reversibly light-switchable drug-conjugates, EP 2116263 A1, 2009. – reference: A.A. Patchett, D. Taub, R.T. Goegelman, Preparation of immunosuppressive cyclosporin A analogs with modified amino acids at position 8, EP 444897 A1, 1991. – volume: 63 start-page: 147 year: 2004 end-page: 154 ident: bb0320 article-title: Cyclosporin A prodrugs: design, synthesis and biophysical properties publication-title: J. Pept. Res. – reference: G. Amouret, A. Guerreiro, C. Viskov, S. Mignani, M. Evers, J.-C. Barriere, G. Bashiardes, J.-C. Carry, B. Filoche, Preparation of cyclosporins modified in position 3 via polyanions and coupling reaction, WO 9932512 A1, 1999. – reference: S.N. Kim, H.J. Ahn, M.K. Kim, J.I. Kim, J.H. Kim, C.W. Lee, M.H. Lee, C.D. Kim, H.S. Cho, H.S. Kim, M.H. Jung, S.J. Kim, Noniummunosuppressive cyclosporin A derivative for hair growth, WO 2001035913 A1, 2001. – volume: 36 start-page: 633 year: 2001 end-page: 640 ident: bb0255 article-title: Spontaneous N–O acyl shift in the [M publication-title: J. Mass Spectrom. – volume: 8 start-page: 103 year: 2007 end-page: 112 ident: bb0545 article-title: ISA 247: trans-ISA 247, trans-R 1524, ISA(TX)247, ISAtx 247, ISATx247, LX 211, LX211, R 1524, R-1524 publication-title: Drugs R&D – reference: A. Ruegger, M. Kuhn, Cyclosporin C derivatives, DE 2648121 A1, 1977. – reference: A.A. Patchett, R.F. White, R.T. Goegelman, Production of cyclosporin derivatives with 3-fluoroalanine at the 8-position, GB 2206119 A, 1988. – reference: M. Neya, S. Yoshimura, K. Kamijyo, T. Makino, M. Yasuda, T. Yamanaka, E. Tsujii, Y. Yamagishi, New cyclic peptide compounds, WO 2007049803 A1, 2007. – reference: D. Davalian, M.H. Beresini, S. Alexander, M.W.-L. Hu, E.F. Ullman, Cyclosporin assay and kit, US 6,190,873 B1, 2001. – volume: 58 start-page: 673 year: 1993 end-page: 677 ident: bb0270 article-title: Preparation of [D-Cysteine] publication-title: J. Org. Chem. – reference: A.A. Patchett, R.F. White, R.T. Goegelman, Method for the production of a modified “8-amino acid” cyclosporin derivative, US 5318901 A, 1994. – volume: 57 start-page: 7145 year: 2014 end-page: 7159 ident: bb0195 article-title: From chemical tools to clinical medicines: nonimmunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds publication-title: J. Med. Chem. – volume: 43 start-page: 953 year: 1992 end-page: 960 ident: bb1215 article-title: Covalent binding of cyclosporine inhibits irreversibly T-lymphocyte activation publication-title: Biochem. Pharmacol. – volume: 43 start-page: 205 year: 2000 end-page: 216 ident: bb0400 article-title: Synthesis of [S-[1- publication-title: J. Label. Compd. Radiopharm. – reference: -[EtVal] – reference: B.F. Molino, Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders, US 20070232531 A1, 2007. – volume: 13 start-page: 136 year: 1992 end-page: 142 ident: bb0180 article-title: The mechanism of action of cyclosporin A and FK506 publication-title: Immunol. Today – volume: 59 start-page: 1075 year: 1976 end-page: 1092 ident: bb0015 article-title: Cyclosporin A, a peptide metabolite from publication-title: Helv. Chim. Acta – reference: Y.S. Or, I.J. Kim, J. Long, L. Jiang, S. Sheng, G. Wang, Preparation of [N-Me-4-hydroxyleucine]-9-cyclosporin analogues as antiviral agents, WO 2014085623 A1, 2014. – reference: M.K. Eberle, Preparation of cyclosporin analogs as drugs, EP 414632 A2, 1991. – volume: 59 start-page: 51 year: 2005 end-page: 56 ident: bb0340 article-title: Conversion of cyclosporine A prodrugs in human tears vs rabbit tears publication-title: Eur. J. Pharm. Biopharm. – reference: S.-N. Kim, H.-J. Ahn, C.-W. Lee, M.-H. Lee, J.-H. Kim, J.-I. Kim, S.-J. Kim, H.-S. Cho, H.-S. Lee, H.-K. Kim, Use of 3-position cyclosporin derivatives for hair growth, US 20030186857 A1, 2003. – reference: S.-N. Kim, H.-J. Ahn, C.-W. Lee, M.-H. Lee, J.-H. Kim, J.-I. Kim, S.-J. Kim, H.-S. Cho, H.-S. Lee, H.-J. Kim, Use of 3-position cyclosporin derivatives for hair growth, WO 2002092032 A1, 2002. – reference: A.A. Patchett, D. Taub, R.T. Goegelman, Synthesis of novel immunosuppressive cyclosporin analogs with modified amino acids at position-8, US 5214130, 1993. – volume: 46 start-page: 674 year: 2003 end-page: 676 ident: bb0590 article-title: Synthesis and biological evaluation of novel cyclosporin A analogues: potential soft drugs for the treatment of autoimmune diseases publication-title: J. Med. Chem. – volume: 11 start-page: 421 year: 2011 end-page: 429 ident: bb1180 article-title: Effects of cyclosporine A and it immunosuppressive or non-immunosuppressive derivatives [D-Ser]8-CsA and Cs9 on mitochondria from different brain regions publication-title: Mitochondrion – volume: 3 start-page: 731 year: 1996 end-page: 738 ident: bb0680 article-title: Controlling programmed cell death with cyclophilin–cyclosporin-based chemical inducer of dimerization publication-title: Chem. Biol. – volume: 119 start-page: 1805 year: 1997 end-page: 1806 ident: bb1300 article-title: Cell-specific calcineurin inhibition by a modified cyclosporin publication-title: J. Am. Chem. Soc. – volume: 45 start-page: 4329 year: 2006 end-page: 4333 ident: bb0640 article-title: Mixed isotope photoaffinity reagents for identification of small-molecule targets by mass spectrometry publication-title: Angew. Chem. Int. Ed. Engl. – volume: 82 start-page: 279 year: 1997 end-page: 314 ident: bb0070 article-title: Biosynthesis of cyclosporins publication-title: Drugs Pharm. Sci. – volume: 425 start-page: 137 year: 2010 end-page: 148 ident: bb0780 article-title: Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation publication-title: Biochem. J. – volume: 3 start-page: 125 year: 1976 end-page: 133 ident: bb0005 article-title: Cyclosporin A and C. New metabolites from publication-title: Eur. J. Appl. Microbiol. – volume: 36 start-page: 3757 year: 1993 end-page: 3764 ident: bb0030 article-title: Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations publication-title: J. Med. Chem. – reference: P. Mouchet, A.R. Rees, E. Elmer, M.F. Keep, Composition for transporting cyclosporin derivatives through the blood brain barrier, WO 2003070755 A2, 2003. – volume: 31 start-page: 173 year: 1998 end-page: 180 ident: bb0425 article-title: Structural characterization of two novel oxidative derivatives of cyclosporine generated by a chemical method publication-title: Clin. Biochem. – start-page: 2935 year: 2009 end-page: 2938 ident: bb0575 article-title: Novel oxidation of cyclosporin A: preparation of cyclosporin methyl vinyl ketone (Cs-MVK) publication-title: Synlett – reference: W.R. Carling, D.A. Scowen, M.E. Garst, M.E. Stern, C.S. Schaumburg, Cyclosporin analogs, WO 2012051193 A1, 2012. – reference: V.R. Chandran, Preparation of amino acid derivatives with high therapeutic index, US 20060241017 A1, 2006. – reference: C.S.V. Frydrych, W.R. Carling, M.E. Garst, M.E. Stern, C.S. Schaumburg, Preparation of cyclosporin analogs as Cyclophilin A inhibitors for treating dry eye and other conditions, WO 2012051194 A1, 2012. – volume: 25 start-page: 110 year: 1997 end-page: 116 ident: bb0225 article-title: H NMR Analysis of isocyclosporin A prepared in organic solvent and in aqueous solution publication-title: Bioorg. Chem. – year: 2014 ident: bb0560 article-title: AURA-LV: aurinia urinary protein reduction active—lupus with voclosporin – volume: 41 start-page: 7193 year: 2000 end-page: 7196 ident: bb0950 article-title: Synthetic routes to NEtXaa publication-title: Tetrahedron Lett. – reference: Y.S. Or, T. Lazarova, J. Chen, Cyclosporins for the treatment of immune disorders, WO 2004072108 A1, 2004. – reference: Y.F. Zheng, D.K. Vickery, S.C. Swann, Methods for detection of cyclosporin A, WO 2009088694 A1, 2009. – volume: 6 start-page: 890 year: 2005 end-page: 899 ident: bb0555 article-title: Exo-mechanism proximity-accelerated alkylations: investigations of linkers, electrophiles and surface mutations in engineered cyclophilin–cyclosporin systems publication-title: ChemBioChem – reference: Y.S. Or, I.J. Kim, G. Wang, J. Long, Preparation of cyclosporin analogs as antiviral agents, US 20110206637 A1 (2011). – volume: 262 start-page: 248 year: 1993 end-page: 250 ident: bb1125 article-title: Structure-based design of a cyclophilin–calcineurin bridging ligand publication-title: Science – volume: 45 start-page: 133 year: 1992 end-page: 135 ident: bb1270 article-title: The preparation of [2-deutero-3-fluoro-D-Ala8]cyclosporin A by directed biosynthesis publication-title: J. Antibiot. – reference: Z. Su, Z. Long, S. Yang, Preparation of novel cyclosporin derivatives for the treatment and prevention of especially a viral infection, WO 2014145686 A2, 2014. – reference: S.Y. Ko, H. Kobel, B. Besemer-Rosenwirth, D. Seebach, R.P. Traber, P. Bollinger, Cyclosporin fermentation process, US 6255100 B1, 2001. – reference: G. Fischer, M. Malesevic, F. Erdmann, J. Kuehling, M. Bukrinsky, S. Constant, Preparation and use of cyclosporin derivatives in the treatment of chronic inflammatory diseases, DE 102009037551 A1, 2011. – reference: J.M. Luchinger, Cyclosporin derivatives with anti-HIV effect, WO 9704005 A2, 1997. – volume: 49 start-page: 781 year: 1996 end-page: 787 ident: bb1040 article-title: Microbial biotransformation products of cyclosporin A publication-title: J. Antibiot. – reference: F. Striggow, W. Schmidt, G. Fischer, M. Theuerkorn, M. Malesevic, M. Weiwad, Compounds for the treatment of neurodegenerative disorders, WO 2014037260 A1, 2014. – reference: R.P. Traber, M. Kuhn, Dihydroisocyclosporin D derivatives, CH 630061 A5, 1982. – reference: F. Striggow, W. Schmidt, G. Fischer, M. Theuerkorn, M. Malesevic, M. Weiwad, Compounds for the treatment of neurodegenerative disorders, EP 2705856, 2014. – volume: 47 start-page: 407 year: 2004 end-page: 414 ident: bb0645 article-title: Synthesis of tritiated Cyclosporin A and FK-506 by metal-catalyzed hydrogen isotope exchange publication-title: J. Label. Compd. Radiopharm. – reference: -cyclosporine modified on the hydroxyl group having a switchable inhibiting effect on protein phosphatase calcineurin and specific manipulatability obtained therewith of the immunosuppressive effect while maintaining inhibition of peptidyl-prolyl-cis-trans-isomerase (PPI) e. g. for the treatment of autoimmune diseases, WO 2005087798 A1, 2005. – volume: 99 start-page: 390 year: 2005 end-page: 395 ident: bb1295 article-title: Production of human metabolites of cyclosporin A, AM1, AM4N and AM9, by microbial conversion publication-title: J. Biosci. Bioeng. – reference: D.R. Houck, K. Li, Arylalkyl and heteroarylalkyl derivatives of cyclosporine A for the treatment and prevention of viral infection, WO 2007041631 A1, 2007. – reference: E. Ellmerer-Mueller, D. Brossner, N. Maslouh, H.-D. Ambrosi, G. Jas, Preparation of novel cyclosporins, WO 9965933 A1, 1999. – volume: 11 start-page: 3 year: 2000 end-page: 7 ident: bb0440 article-title: Synthesis of bioadhesive lectin–HMPA copolymer–cyclosporin conjugates publication-title: Bioconjug. Chem. – volume: 63 start-page: 728 year: 1980 end-page: 732 ident: bb0395 article-title: Improvement of detection sensitivity of cyclosporin A by derivitization with 2-naphthylselenyl chloride publication-title: Helv. Chim. Acta – volume: 23 start-page: 4485 year: 2013 end-page: 4492 ident: bb0200 article-title: Cyclophilin inhibitors as antiviral agents publication-title: Bioorg. Med. Chem. Lett. – volume: 4 start-page: 2051 year: 2002 end-page: 2054 ident: bb0585 article-title: Synthesis of cyclosporin A-derived affinity reagents by olefin metathesis publication-title: Org. Lett. – reference: -cyclosporin for the treatment of hepatitis C infection and pharmaceutical composition comprising said [D-MeAla] – volume: 60 start-page: 2610 year: 1995 end-page: 2612 ident: bb0415 article-title: Preparation of sulfhydryl cyclosporin A publication-title: J. Org. Chem. – volume: 12 start-page: 129 year: 2001 end-page: 133 ident: bb0570 article-title: Modification of cyclosporin A and conjugation of its derivative to HPMA copolymers publication-title: Bioconjug. Chem. – reference: R.M. Wenger, M. Mutter, T. Ruckle, Cyclosporin with improved activity profile, US 6927208 B1, 2005. – reference: K. Li, D.R. Houck, C.O. Ogbu, M.R. Peel, A.W. Scribner, Derivatives of cyclosporin A, WO 2010076329 A1, 2010. – reference: R.P. Traber, M. Kuhn, Antibiotic derivatives of dihydrocyclosporin B, CH 628872 A5, 1982. – volume: 269 start-page: 14199 year: 1994 end-page: 14204 ident: bb1210 article-title: Mapping of the immunophilin-immunosuppressant site of interaction on calcineurin publication-title: J. Biol. Chem. – volume: 59 start-page: 1480 year: 1976 end-page: 1488 ident: bb0025 article-title: Crystal and molecular structure of an iodo-derivative of the cyclic undecapeptide cyclosporin A publication-title: Helv. Chim. Acta – reference: Y.S. Or, T. Lazarova, J.S.-H. Chen, Preparation of cyclosporins for the treatment of immune disorders, US 20040110666 A1, 2004. – reference: M.E. Garst, M.E. Stern, Cyclosporin derivatives for treating inflammatory diseases and conditions, WO 2010138423 A1, 2010. – volume: 173 start-page: 619 year: 1991 end-page: 628 ident: bb0445 article-title: Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A? publication-title: J. Exp. Med. – volume: 6 start-page: 4358 year: 2000 end-page: 4363 ident: bb0710 article-title: Pseudoprolines (ΨPro) in drug design: direct insertion of ΨPro systems into cyclosporin C publication-title: Chem. Eur. J. – volume: 6 start-page: 1127 year: 1998 end-page: 1152 ident: bb1135 article-title: Chemical genetics resulting from a passion for synthetic organic chemistry publication-title: Bioorg. Med. Chem. – reference: G. Amouret, A. Guerreiro, C. Viskov, S. Mignani, M. Evers, J.-C. Barriere, G. Bashiardes, J.-C. Carry, B. Filoche, Novel method for preparing cyclosporin derivatives, EP 1040121 B1, 1999. – volume: 49 start-page: 966 year: 2001 end-page: 969 ident: bb0135 article-title: Low dose cyclosporine-A therapy in severe aplastic anaemia publication-title: J. Assoc. Physicians India – reference: M. Kuhn, A. Ruegger, Cyclosporin C and dihydrocyclosporin C, US 4210581 A, 1980. – volume: 3 start-page: 32 year: 1992 end-page: 36 ident: bb0430 article-title: Preparation of novel cyclosporin A derivatives publication-title: Bioconjug. Chem. – volume: 49 start-page: 191 year: 1997 end-page: 194 ident: bb0240 article-title: Hydrolytic conditions for the formation of open-chain oligopeptides from cyclosporin A publication-title: J. Pept. Res. – reference: S. Naicker, R.W. Yatscoff, R.T. Foster, Synthesis of cyclosporin analog mixtures and their use as immunomodulating agents, WO 2003033527 A2, 2003. – reference: H.G. Fliri, D.R. Houck, 3-Ether and 3-thioether substituted cyclosporin derivatives for the treatment and prevention of hepatitis C infection, WO 2006039668 A2, 2006. – reference: Y.S. Or, T. Lazarova, Preparation of cyclosporin analogs for the treatment of lung diseases, WO 2003030834 A2, 2003. – volume: 20 start-page: 313 year: 1988 end-page: 318 ident: bb1280 article-title: Cyclosporine: conformation and analogs as tools for studying its mechanism of action publication-title: Transplant. Proc. – volume: 5 start-page: 187 year: 1997 end-page: 192 ident: bb0050 article-title: Conformational control of cyclosporin through substitution of the N-5 position. A new class of cyclosporin antagonists publication-title: Bioorg. Med. Chem. – volume: 99 start-page: 12037 year: 2002 end-page: 12042 ident: bb0150 article-title: Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin-drug complexes publication-title: Proc. Natl. Acad. Sci. U. S. A. – reference: A. Margaritis, P.A. Paprica, N.O. Peterson, Preparation of cyclosporin acid derivatives and derivative conjugates, CA 2086267 A1, 1994. – volume: 279 start-page: 2470 year: 2004 end-page: 2479 ident: bb0165 article-title: Substitution in position 3 of cyclosporin A abolishes the cyclophilin-mediated gain-of-function mechanism but not immunosuppression publication-title: J. Biol. Chem. – reference: S.S. Naicker, R.W. Yatscoff, R.T. Foster, Preparation of deuterated cyclosporin analogs and their use as immunosuppressants, WO 9918120 A1, 1999. – volume: 74 start-page: 1953 year: 1991 end-page: 1990 ident: bb1025 article-title: Thiocyclosporins: preparation, solution and crystal structure, and immunosuppressive activity publication-title: Helv. Chim. Acta – volume: 24 start-page: 662 year: 2004 end-page: 669 ident: bb0345 article-title: Water soluble cyclosporine monoethoxy poly(ethyleneglycol) conjugates as potential prodrugs publication-title: Arch. Pharm. Sci. Res. – volume: 70 start-page: 13 year: 1987 end-page: 36 ident: bb0105 article-title: Novel cyclosporins from publication-title: Helv. Chim. Acta – volume: 65 start-page: 1655 year: 1982 end-page: 1677 ident: bb0100 article-title: Isolation and structure determination of the new cyclosporins E, F, G, H and I publication-title: Helv. Chim. Acta – volume: 2 start-page: 65 year: 2007 end-page: 78 ident: bb0185 article-title: Role of cyclophilin A in HIV replication publication-title: Futur. Virol. – reference: R.M. Wenger, M. Mutter, T. Ruckle, Novel cyclosporin with improved activity profile, pharmaceutical composition, and use in the treatment of AIDS, WO 2000001715 A1, 2000. – volume: 59 start-page: 7249 year: 1994 end-page: 7258 ident: bb1030 article-title: Cyclosporin A: regioselective ring opening and fragmentation reactions publication-title: J. Org. Chem. – volume: 48 start-page: 6268 year: 2009 end-page: 6277 ident: bb0170 article-title: Isoform-specific inhibition of cyclophilins publication-title: Biochemistry – reference: Z. Su, Z. Long, Z. Huang, S. Yang, Preparation of novel cyclosporin derivatives for the treatment and prevention of a viral infection, WO 2013028615 A2, 2013. – volume: 185 start-page: 7663 year: 2010 end-page: 7670 ident: bb1175 article-title: A cell-impermeable cyclosporine A derivative reduces pathology in a mouse model of allergic lung inflammation publication-title: J. Immunol. – reference: S.-N. Kim, Y.-K. Yoon, M.-M. Kim, J.I. Kim, S.-J. Kim, H.-J. Kim, H.S. Lee, Use of 3-position cyclosporin derivatives for hair growth, US 20040087496 A1, 2004 – volume: 60 start-page: 1247 year: 1977 end-page: 1255 ident: bb0090 article-title: The structure of cyclosporin C publication-title: Helv. Chim. Acta – volume: vol. 7 start-page: 535 year: 1997 end-page: 591 ident: bb0065 article-title: Cyclosporins: recent developments in biosynthesis, pharmacology and biology, and clinical applications publication-title: Biotechnology – volume: 5 start-page: 56 year: 1999 end-page: 58 ident: bb0965 article-title: Efficient one-pot synthesis of N-ethyl amino acids publication-title: J. Pept. Sci. – reference: Y.S. Or, T. Lazarova, B.C. Hamann, Cyclosporins for the treatment of respiratory diseases, WO 2002069902 A2, 2002. – reference: J.M. Luchinger, Cyclosporin derivatives with anti-HIV effect, US 5948884, 1999. – reference: Z. Su, Z. Long, Z. Huang, S. Yang, Novel cyclosporin derivatives for the treatment and prevention of a viral infection, WO 2012075494 A1, 2012. – volume: 38 start-page: 403 year: 1995 end-page: 407 ident: bb0075 article-title: Cyclosporins from publication-title: Phytochemistry – volume: 2 start-page: 1621 year: 2010 end-page: 1634 ident: bb0190 article-title: Cyclophilin inhibitors as a novel HCV therapy publication-title: Viruses – volume: 80 start-page: 363 year: 1991 end-page: 367 ident: bb0260 article-title: Synthesis of a fluorescent derivative of cyclosporin A for high-performance liquid chromatography analysis publication-title: J. Pharm. Sci. – reference: P. Scalfaro, J.-M. Dumont, G. Vuagniaux, R.-Y. Mauvernay, Use of [D-MeAla] – volume: 46 start-page: 775 year: 2009 end-page: 780 ident: bb0215 article-title: A CaPful of mechanisms regulating the mitochondrial permeability transition publication-title: J. Mol. Cell. Cardiol. – volume: 57 start-page: 8503 year: 2014 end-page: 8516 ident: bb1020 article-title: Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition publication-title: J. Med. Chem. – reference: B.F. Molino, Preparation of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders, WO 2007112352 A2, 2007. – volume: 14 start-page: 4549 year: 2004 end-page: 4551 ident: bb0490 article-title: Synthesis and neurotrophic activity of nonimmunosuppressant cyclosporin A derivatives publication-title: Bioorg. Med. Chem. Lett. – reference: Z. Su, Z. Long, Z. Huang, S. Yang, Novel cyclosporin derivatives for the treatment and prevention of a viral infection, WO 2012021796 A2, 2012. – volume: 93 start-page: 1583 year: 2010 end-page: 1601 ident: bb1120 article-title: Stereoselective Synthesis of [5-[4,4,4,4′,4′,4′-Hexafluoro- publication-title: Helv. Chim. Acta – reference: B.F. Molino, Preparation of cyclosporin alkyne analogues for preventing or treating viral-induced disorders, WO 2007112357 A2, 2007. – reference: X. Gao, Y.S. Or, G. Wang, J. Long, Preparation of cyclosporin analogs for treatment of diseases, US 20110008284 A1, 2011. – volume: 30 start-page: 4215 year: 1989 end-page: 4218 ident: bb0450 article-title: A semi-synthetic approach to olefinic analogs of amino acid one (MeBmt) in cyclosporin A publication-title: Tetrahedron Lett. – reference: K. Li, Preparation of cyclosporin derivatives, WO 2008143996 A1, 2008. – reference: Y.F. Zheng, T.Q. Wei, Stabilization of solid support assay reagents, WO 2009089262 A1, 2009. – reference: D. Selwood, M. Crompton, Cyclosporin conjugates, WO 2011010084 A2, 2011. – volume: 152 start-page: 597 year: 2005 end-page: 615 ident: bb0110 article-title: Traditional therapies in the management of moderate to severe chronic plaque psoriasis: an assessment of the benefits and risks publication-title: Br. J. Dermatol. – reference: Y. Cheng, W. Zheng, L. He, L. Xiao, Preparation of derivatives of cyclosporin C and D, CN 101041689 A, 2007. – reference: J.-C. Barriere, G. Bashiardes, J.-C. Carry, M. Evers, B. Filoche, J.P. Leconte, S. Mignani, Cyclosporin compounds, their preparation and the pharmaceutical compositions which contain them, US 5965527, 1999. – reference: P.L. Durette, J. Kollonitsch, A.A. Pessolano, Novel immunosuppressive fluorinated cyclosporin analogs, GB 2207678 A, 1989. – volume: 45 start-page: 4613 year: 2002 end-page: 4628 ident: bb0085 article-title: Cyclosporins: structure–activity relationships for the inhibition of the human publication-title: J. Med. Chem. – volume: 852 start-page: 345 year: 2007 end-page: 352 ident: bb1035 article-title: Determination of ciclosporin A and its six main metabolites in isolated T-lymphocytes and whole blood using liquid chromatography-tandem mass spectrometry publication-title: J. Chromatogr. B Anal. Technol. Biomed. Life Sci. – volume: 1 start-page: 48 year: 1995 end-page: 63 ident: bb0145 article-title: A critical review of cyclosporine therapy in inflammatory bowel disease publication-title: Inflamm. Bowel Dis. – reference: M. Evers, S. Mignani, J.-C. Carry, B. Filoche, G. Bashiardes, C. Bensoussan, J.-C. Gueguen, J.-C. Barriere, Cyclosporin derivatives, their preparation and the pharmaceutical compositions which contain them, US 5977067, 1999. – volume: 46 start-page: 5556 year: 2011 end-page: 5561 ident: bb0290 article-title: Oligopeptide cyclophilin inhibitors: a reassessment publication-title: Eur. J. Med. Chem. – reference: G. Fischer, M. Malesevic, F. Erdmann, J. Kuehling, M. Bukrinsky, S. Constant, G. Ruehter, P. Nussbaumer, K. Dinkel, Synthesis of cyclosporin derivatives for use in diagnosis or treatment of disease, plant protection, or pest control, WO 2013030208 A1, 2013. – reference: R. Wenger, Preparation of iso-cyclosporin salts as drugs, WO 9317039 A1, 1993. – volume: 24 start-page: 77 year: 1985 end-page: 85 ident: bb0035 article-title: Synthesis of cyclosporine and analogues: structural requirements for immunosuppressive activity publication-title: Angew. Chem. Int. Ed. Engl. – reference: G. Fischer, Y. Zhang, R. Baumgrass, F. Erdmann, D-Ser – volume: 34 start-page: 505 year: 1994 end-page: 511 ident: bb0060 article-title: Effect of temperature on molecular structure of cyclosporin A publication-title: Biochem. Mol. Biol. Int. – reference: N.Y. Wang, P.P. Wang, M.A. Morrison, Fluorescence polarization immunoassay for cyclosporin A and metabolites based on novel cyclosporin A derivatives, EP 283801 A2, 1988. – reference: Y.S. Or, Cyclosporins for the treatment of immune disorders, US 20030186855 A1, 2003. – reference: A.W. Fulmer, J.P. Tiesman, C.R. Degenhardt, D.J. Eickhoff, J.M. McIver, Method of treating hair loss using non-immunosuppressive compounds, WO 200051558, 2000. – start-page: 173 year: 1996 end-page: 178 ident: bb0235 publication-title: Peptides 1996, Proceedings of the European Peptide Symposium – volume: 38 start-page: 1853 year: 1995 end-page: 1864 ident: bb1165 article-title: Preparation and in vitro activities of ethers of [D-serine] publication-title: J. Med. Chem. – reference: M. Mutter, R. Wenger, J.-F. Guichou, M. Keller, T. Ruckle, T. Woehr, Cyclosporin derivatives and method for the production of said derivatives, US 6790935 B1, 2004. – volume: 45 start-page: 94 year: 1992 end-page: 102 ident: bb1265 article-title: Analogs of cyclosporin A modified at the D-Ala8 position publication-title: J. Antibiot. – reference: K. Li, A. Mamai, M.R. Peel, Novel macrocyclic peptides, analogs of cyclosporin A, their preparation and their use in the treatment of HCV infections, WO 2010002428 A2, 2009. – start-page: 384 year: 2013 end-page: 418 ident: bb0205 article-title: Optimization of cyclophilin inhibitors for use in antiviral therapy publication-title: Successful Strategies for the Discovery of Antiviral Drugs – reference: -cyclosporin, WO 2006038088 A1, 2006. – reference: B.F. Molino, Preparation of cyclosporin alkyne analogs for preventing or treating viral-induced disorders, US 7696165 B2, 2010. – reference: S.N. Pettit, A.D. Jones, C.S.V. Frydrych, W.R. Carling, M.E. Garst, Preparation of cyclosporin A analogs as Cyclophilin A inhibitors for treating dry eye and other conditions, WO 2013181339 A2, 2013. – start-page: 316 year: 2004 end-page: 320 ident: bb0275 article-title: Semisynthetic di- and tri-functionalized non-immunosuppressive cyclosporin A derivatives as potential anti-HIV 1 drugs publication-title: Synlett – volume: 99 start-page: 13522 year: 2002 end-page: 13526 ident: bb0160 article-title: Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin publication-title: Proc. Natl. Acad. Sci. U. S. A. – volume: 65 start-page: 364 year: 2005 end-page: 374 ident: bb0315 article-title: Water-soluble prodrugs of cyclosporine A with tailored conversion rates publication-title: J. Pept. Res. – volume: 35 start-page: 6477 year: 1994 end-page: 6480 ident: bb0390 article-title: Preparation of functionalized ethers of cyclosporin A publication-title: Tetrahedron Lett. – reference: B.F. Molino, Preparation of cyclosporin alkyne/alkene analogues for preventing or treating viral-unduced disorders, US 7696166 B2, 2010. – reference: G. Towers, D. Selwood, J. Rasaiyaah, Non-immunosuppressive cyclosporin derivatives as antiviral agents, WO 2014132084 A1, 2014. – volume: 681 start-page: 539 year: 1993 end-page: 551 ident: bb0130 article-title: A clinical therapeutic trial of cyclosporine in myasthenia gravis publication-title: Ann. N. Y. Acad. Sci. – reference: J.J. Boelsterli, M.K. Eberle, R. Naef, T.G. Payne, Preparation of cyclosporin derivatives as immunosuppressants and antiinflammatories, CA 2090634 A1, 1993. – volume: 42 start-page: 591 year: 1989 end-page: 597 ident: bb1060 article-title: Cyclosporins—new analogs by precursor directed biosynthesis publication-title: J. Antibiot. – volume: 55 start-page: 2895 year: 1990 end-page: 2903 ident: bb1285 article-title: Synthesis of D-lysine publication-title: J. Org. Chem. – volume: 4 start-page: 267 year: 1994 end-page: 272 ident: bb0980 article-title: Calcineurin has a very tight-binding pocket for the side chain of residue 4 of cyclosporin publication-title: Bioorg. Med. Chem. Lett. – reference: Y.S. Or, G. Wang, X. Gao, J. Long, Preparation of cyclosporin analogs for treatment of disease, US 20100209390 A1, 2010. – reference: Y.S. Or, T. Lazarova, B. Hamann, J. Chen, Preparation of cyclosporin analogs for the treatment of autoimmune diseases, WO 2003033010 A1, 2003. – volume: 268 start-page: F46 year: 1995 end-page: F52 ident: bb1220 article-title: P-glycoprotein-mediated secretion of a fluorescent cyclosporin analog by teleost renal proximal tubules publication-title: Am. J. Physiol. – volume: 43 start-page: 1377 year: 1993 end-page: 1384 ident: bb0140 article-title: A randomized trial of cyclosporine in steroid-resistant idiopathic nephrotic syndrome publication-title: Kidney Int. – reference: E. Ellmerer-Mueller, D. Brossner, N. Maslouh, H.-D. Ambrosi, G. Jas, G. Fischer, Novel cyclosporins, EP 1086124 B1, 1999. – reference: B.F. Molino, Z. Yang, Preparation of cyclosporin alkynes as pharmaceutical agents, US 20060074015 A1, 2006. – volume: 60 start-page: 4868 year: 1995 end-page: 4872 ident: bb1240 article-title: Bridged cyclosporins publication-title: J. Org. Chem. – volume: 32 start-page: 492 year: 1986 end-page: 495 ident: bb0705 article-title: Use of publication-title: Clin. Chem. – volume: 68 start-page: 682 year: 1985 end-page: 704 ident: bb0020 article-title: Peptide conformations. Part 31. The conformation of cyclosporin A in the crystal and in solution publication-title: Helv. Chim. Acta – reference: M.E. Garst, Preparation of cyclosporin derivatives for treating ocular and dermal diseases and conditions, WO 2010006117 A2, 2010. – reference: J. Long, Y.S. Or, X. Gao, G. Wang, Preparation of cyclosporin analogs for treatment of diseases, US 20110008285 A1, 2011. – reference: Y.S. Or, T. Lazarova, J. Eckstein, Cyclosporins for the treatment of immune disorders, US 20030166515 A1, 2003. – volume: 356 start-page: 100 year: 2006 end-page: 107 ident: bb0280 article-title: A fluorescence polarization-based assay for peptidyl prolyl cis/trans isomerase cyclophilin A publication-title: Anal. Biochem. – reference: E. Ellmerer-Mueller, D. Brossner, N. Maslouh, H.D. Ambrosi, G. Jas, G. Fischer, Cyclosporins, US 6583265 B1, 2003. – start-page: 381 year: 1994 end-page: 392 ident: bb1130 article-title: Synthesis, structure and mechanism in immunophilin research publication-title: Synlett – volume: 41 start-page: 113 year: 2009 end-page: 121 ident: bb0210 article-title: Mitochondria and reperfusion injury of the heart—a holey death but not beyond salvation publication-title: J. Bioenerg. Biomembr. – volume: 37 start-page: 3674 year: 1994 end-page: 3676 ident: bb0975 article-title: Improved binding affinity for cyclophilin A by a cyclosporin derivative singly modified at its effector domain publication-title: J. Med. Chem. – reference: S.Y. Ko, H. Kobel, B. Besemer-Rosenwirth, D. Seebach, R.P. Traber, R. Wenger, P. Bollinger, Cyclosporins, US 5767069, 1998. – reference: J. Rosenthaler, R. Wenger, P.E. Ball, M.H. Schreier, V. Quesniaux, Monoclonal antibodies to cyclosporins, WO 8602080 A1, 1986. – volume: 205 start-page: 65 year: 1992 end-page: 69 ident: bb1235 article-title: Fluorescence displacement method for the determination of receptor-ligand binding constants publication-title: Anal. Biochem. – reference: M.E. Garst, Eye disorders treatment with cyclosporin-A derivatives, WO 2000061168 A1, 2000. – volume: 262 start-page: 17258 year: 1987 end-page: 17259 ident: bb1145 article-title: Enzymic synthesis of cyclosporin A publication-title: J. Biol. Chem. – volume: 13 start-page: 3157 year: 2005 end-page: 3167 ident: bb0360 article-title: Novel cyclosporin derivatives featuring enhanced skin penetration despite increased molecular weight publication-title: Bioorg. Med. Chem. – reference: R.P. Traber, M. Kuhn, H. Hofmann, E. Haerri, Cyclosporin derivatives, CH 640520, 1984. – reference: D. Seebach, Novel cyclosporins, US 4771122 (1988). – reference: J.-C. Barriere, J.-C. Carry, B. Filoche, M. Evers, G. Bashiardes, S. Mignani, Preparation of cyclosporin derivatives and their pharmaceutical compositions, FR 2757520 A1, 1998. – reference: J.-C. Barriere, J.-C. Carry, B. Filoche, M. Evers, G. Bashiardes, S. Mignani, Preparation of cyclosporin derivatives and their pharmaceutical compositions, FR 2757521 A1, 1998. – reference: G. Fischer, Y. Zhang, R. Baumgrass, F. Erdmann, G. Kuellertz, Switchable nonimmunosuppressant cyclosporin derivatives, their preparation, pharmaceutical compositions containing them, and their therapeutic use, DE 102004011988 A1, 2005. – reference: K. Li, M.R. Peel, Novel macrocyclic peptides, analogs of cyclosporin A, their preparation and their use in the treatment of HCV infections, WO 2011070364 A1, 2011. – reference: M.D. Abel, D.P. Czajkowski, B.W. Fenske, A. Hegmans, D. McGlade, D.J. Trepanier, D.R. Ure, S. Sugiyama, Preparation of nonimmunosuppressive cyclosporin analogs for treating cyclophilin mediated diseases, WO 2010012073 A1, 2010. – reference: K. Li, A. Mamai, M.R. Peel, Novel macrocyclic peptides, analogs of cyclosporin A, their preparation and their use in the treatment of HCV infections, US 20090312300 A1, 2009. – volume: 311 start-page: 1095 year: 2003 ident: 10.1016/j.bbagen.2015.02.008_bb0155 article-title: Structures of calcineurin and its complexes with immunophilins-immunosuppressants publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/S0006-291X(03)01537-7 – volume: 26 start-page: 2102 year: 1999 ident: 10.1016/j.bbagen.2015.02.008_bb0125 article-title: Cyclosporine A in rheumatoid arthritis: randomized, placebo controlled dose finding study publication-title: J. Rheumatol. – volume: 45 start-page: 133 year: 1992 ident: 10.1016/j.bbagen.2015.02.008_bb1270 article-title: The preparation of [2-deutero-3-fluoro-D-Ala8]cyclosporin A by directed biosynthesis publication-title: J. Antibiot. doi: 10.7164/antibiotics.45.133 – volume: 45 start-page: 4598 year: 2002 ident: 10.1016/j.bbagen.2015.02.008_bb0080 article-title: Cyclosporins: structure–activity relationships for the inhibition of the human MDR1 P-glycoprotein ABC transporter publication-title: J. Med. Chem. doi: 10.1021/jm0109863 – volume: 37 start-page: 3674 year: 1994 ident: 10.1016/j.bbagen.2015.02.008_bb0975 article-title: Improved binding affinity for cyclophilin A by a cyclosporin derivative singly modified at its effector domain publication-title: J. Med. Chem. doi: 10.1021/jm00048a002 – volume: 262 start-page: 248 year: 1993 ident: 10.1016/j.bbagen.2015.02.008_bb1125 article-title: Structure-based design of a cyclophilin–calcineurin bridging ligand publication-title: Science doi: 10.1126/science.8211144 – volume: 43 start-page: 1377 year: 1993 ident: 10.1016/j.bbagen.2015.02.008_bb0140 article-title: A randomized trial of cyclosporine in steroid-resistant idiopathic nephrotic syndrome publication-title: Kidney Int. doi: 10.1038/ki.1993.194 – ident: 10.1016/j.bbagen.2015.02.008_bb0470 – volume: 4 start-page: 267 year: 1994 ident: 10.1016/j.bbagen.2015.02.008_bb0980 article-title: Calcineurin has a very tight-binding pocket for the side chain of residue 4 of cyclosporin publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/S0960-894X(01)80127-X – ident: 10.1016/j.bbagen.2015.02.008_bb1010 – ident: 10.1016/j.bbagen.2015.02.008_bb0715 – volume: 20 start-page: 6542 year: 2010 ident: 10.1016/j.bbagen.2015.02.008_bb0285 article-title: Synthesis and biological evaluation of [D-lysine]8cyclosporin A analogs as potential anti-HCV agents publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2010.09.036 – ident: 10.1016/j.bbagen.2015.02.008_bb0985 – ident: 10.1016/j.bbagen.2015.02.008_bb1085 – volume: 43 start-page: 953 year: 1992 ident: 10.1016/j.bbagen.2015.02.008_bb1215 article-title: Covalent binding of cyclosporine inhibits irreversibly T-lymphocyte activation publication-title: Biochem. Pharmacol. doi: 10.1016/0006-2952(92)90598-D – volume: 5 start-page: 56 year: 1999 ident: 10.1016/j.bbagen.2015.02.008_bb0965 article-title: Efficient one-pot synthesis of N-ethyl amino acids publication-title: J. Pept. Sci. doi: 10.1002/(SICI)1099-1387(199901)5:1<56::AID-PSC186>3.0.CO;2-J – ident: 10.1016/j.bbagen.2015.02.008_bb0910 – volume: 280 start-page: 4842 year: 2005 ident: 10.1016/j.bbagen.2015.02.008_bb1155 article-title: Unexpected side chain effects at residue 8 of cyclosporin A derivatives allow photoswitching of immunosuppression publication-title: J. Biol. Chem. doi: 10.1074/jbc.M409178200 – volume: 65 start-page: 364 year: 2005 ident: 10.1016/j.bbagen.2015.02.008_bb0315 article-title: Water-soluble prodrugs of cyclosporine A with tailored conversion rates publication-title: J. Pept. Res. doi: 10.1111/j.1399-3011.2005.00234.x – volume: 279 start-page: 2470 year: 2004 ident: 10.1016/j.bbagen.2015.02.008_bb0165 article-title: Substitution in position 3 of cyclosporin A abolishes the cyclophilin-mediated gain-of-function mechanism but not immunosuppression publication-title: J. Biol. Chem. doi: 10.1074/jbc.M304754200 – volume: 99 start-page: 12037 year: 2002 ident: 10.1016/j.bbagen.2015.02.008_bb0150 article-title: Crystal structure of calcineurin–cyclophilin–cyclosporin shows common but distinct recognition of immunophilin-drug complexes publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.192206699 – ident: 10.1016/j.bbagen.2015.02.008_bb0865 – volume: 59 start-page: 51 year: 2005 ident: 10.1016/j.bbagen.2015.02.008_bb0340 article-title: Conversion of cyclosporine A prodrugs in human tears vs rabbit tears publication-title: Eur. J. Pharm. Biopharm. doi: 10.1016/j.ejpb.2004.07.002 – volume: 3 start-page: 125 year: 1976 ident: 10.1016/j.bbagen.2015.02.008_bb0005 article-title: Cyclosporin A and C. New metabolites from Trichoderma polysporum (Link ex Pers.) Rifai publication-title: Eur. J. Appl. Microbiol. doi: 10.1007/BF00928431 – ident: 10.1016/j.bbagen.2015.02.008_bb1050 – volume: 43 start-page: 205 year: 2000 ident: 10.1016/j.bbagen.2015.02.008_bb0400 article-title: Synthesis of [S-[1-14C]Val7]VALSPODAR Application of (+)/(−)-[13,14Cn]BABS and (+)/(−)-[13,14Cn]DPMGBS, part 4 publication-title: J. Label. Compd. Radiopharm. doi: 10.1002/(SICI)1099-1344(20000315)43:3<205::AID-JLCR303>3.0.CO;2-4 – ident: 10.1016/j.bbagen.2015.02.008_bb0830 – volume: 28 start-page: 1440 year: 1993 ident: 10.1016/j.bbagen.2015.02.008_bb0230 article-title: Sequencing of cyclosporins by fast atom bombardment and linked-scan mass spectrometry publication-title: Org. Mass Spectrom. doi: 10.1002/oms.1210281214 – ident: 10.1016/j.bbagen.2015.02.008_bb0550 – volume: 4 start-page: 2051 year: 2002 ident: 10.1016/j.bbagen.2015.02.008_bb0585 article-title: Synthesis of cyclosporin A-derived affinity reagents by olefin metathesis publication-title: Org. Lett. doi: 10.1021/ol0258987 – volume: 74 start-page: 1953 year: 1991 ident: 10.1016/j.bbagen.2015.02.008_bb1025 article-title: Thiocyclosporins: preparation, solution and crystal structure, and immunosuppressive activity publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19910740833 – ident: 10.1016/j.bbagen.2015.02.008_bb1245 – ident: 10.1016/j.bbagen.2015.02.008_bb0435 – volume: 46 start-page: 5556 year: 2011 ident: 10.1016/j.bbagen.2015.02.008_bb0290 article-title: Oligopeptide cyclophilin inhibitors: a reassessment publication-title: Eur. J. Med. Chem. doi: 10.1016/j.ejmech.2011.09.019 – volume: 272 start-page: 6647 year: 1997 ident: 10.1016/j.bbagen.2015.02.008_bb0775 article-title: Molecular interactions of cyclosporin A with P-glycoprotein. Photolabeling with cyclosporin derivatives publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.10.6647 – ident: 10.1016/j.bbagen.2015.02.008_bb0915 – ident: 10.1016/j.bbagen.2015.02.008_bb0670 – ident: 10.1016/j.bbagen.2015.02.008_bb0350 – volume: 74 start-page: 197 year: 1991 ident: 10.1016/j.bbagen.2015.02.008_bb0040 article-title: C-Alkylation of peptides through polylithiated and LiCl-solvated derivatives containing sarcosine Li-enolate units publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19910740121 – volume: 60 start-page: 1568 year: 1977 ident: 10.1016/j.bbagen.2015.02.008_bb0095 article-title: New cyclopeptides from Trichoderma polysporum (Link ex Pers.) Rifai: cyclosporins B, D and E publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19770600513 – ident: 10.1016/j.bbagen.2015.02.008_bb1160 – start-page: 316 year: 2004 ident: 10.1016/j.bbagen.2015.02.008_bb0275 article-title: Semisynthetic di- and tri-functionalized non-immunosuppressive cyclosporin A derivatives as potential anti-HIV 1 drugs publication-title: Synlett doi: 10.1055/s-2004-815405 – volume: 63 start-page: 147 year: 2004 ident: 10.1016/j.bbagen.2015.02.008_bb0320 article-title: Cyclosporin A prodrugs: design, synthesis and biophysical properties publication-title: J. Pept. Res. doi: 10.1111/j.1399-3011.2003.00111.x – volume: 425 start-page: 137 year: 2010 ident: 10.1016/j.bbagen.2015.02.008_bb0780 article-title: Mitochondrial targeting of cyclosporin A enables selective inhibition of cyclophilin-D and enhanced cytoprotection after glucose and oxygen deprivation publication-title: Biochem. J. doi: 10.1042/BJ20090332 – volume: 3 start-page: 32 year: 1992 ident: 10.1016/j.bbagen.2015.02.008_bb0430 article-title: Preparation of novel cyclosporin A derivatives publication-title: Bioconjug. Chem. doi: 10.1021/bc00013a005 – volume: 6 start-page: 1253 year: 2000 ident: 10.1016/j.bbagen.2015.02.008_bb0355 article-title: Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation publication-title: Nat. Med. doi: 10.1038/81359 – volume: 6 start-page: 23 year: 1996 ident: 10.1016/j.bbagen.2015.02.008_bb0760 article-title: Anti HIV-1 activity of a hydrophilic cyclosporin derivative with improved binding affinity to cyclophilin A publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/0960-894X(95)00553-6 – volume: 99 start-page: 13522 year: 2002 ident: 10.1016/j.bbagen.2015.02.008_bb0160 article-title: Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.212504399 – volume: 7 start-page: 257 year: 1996 ident: 10.1016/j.bbagen.2015.02.008_bb1225 article-title: Detection of P-glycoprotein expression by tumoral cells with NBDL-CsA, a fluorescent derivative of cyclosporin A publication-title: Anti-Cancer Drugs doi: 10.1097/00001813-199605000-00004 – volume: 70 start-page: 13 year: 1987 ident: 10.1016/j.bbagen.2015.02.008_bb0105 article-title: Novel cyclosporins from Tolypocladium inflatum. Cyclosporins K–Z publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19870700103 – ident: 10.1016/j.bbagen.2015.02.008_bb0870 – ident: 10.1016/j.bbagen.2015.02.008_bb0245 – ident: 10.1016/j.bbagen.2015.02.008_bb0520 – volume: 45 start-page: 4329 year: 2006 ident: 10.1016/j.bbagen.2015.02.008_bb0640 article-title: Mixed isotope photoaffinity reagents for identification of small-molecule targets by mass spectrometry publication-title: Angew. Chem. Int. Ed. Engl. doi: 10.1002/anie.200600743 – volume: 1 start-page: 48 year: 1995 ident: 10.1016/j.bbagen.2015.02.008_bb0145 article-title: A critical review of cyclosporine therapy in inflammatory bowel disease publication-title: Inflamm. Bowel Dis. doi: 10.1097/00054725-199503000-00006 – volume: 5 start-page: 1725 year: 1995 ident: 10.1016/j.bbagen.2015.02.008_bb0380 article-title: Modifications of the MeBmt side chain of cyclosporin A publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/0960-894X(95)00281-W – volume: 63 start-page: 728 year: 1980 ident: 10.1016/j.bbagen.2015.02.008_bb0395 article-title: Improvement of detection sensitivity of cyclosporin A by derivitization with 2-naphthylselenyl chloride publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19800630323 – volume: 14 start-page: 63 year: 2013 ident: 10.1016/j.bbagen.2015.02.008_bb0690 article-title: Fine tuning the inhibition profile of cyclosporine A by derivitization of the MeBmt residue publication-title: Chembiochem doi: 10.1002/cbic.201200621 – volume: 45 start-page: 94 year: 1992 ident: 10.1016/j.bbagen.2015.02.008_bb1265 article-title: Analogs of cyclosporin A modified at the D-Ala8 position publication-title: J. Antibiot. doi: 10.7164/antibiotics.45.94 – ident: 10.1016/j.bbagen.2015.02.008_bb1015 – volume: 14 start-page: 4549 year: 2004 ident: 10.1016/j.bbagen.2015.02.008_bb0490 article-title: Synthesis and neurotrophic activity of nonimmunosuppressant cyclosporin A derivatives publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2004.06.028 – ident: 10.1016/j.bbagen.2015.02.008_bb0525 – ident: 10.1016/j.bbagen.2015.02.008_bb0800 – ident: 10.1016/j.bbagen.2015.02.008_bb0825 – ident: 10.1016/j.bbagen.2015.02.008_bb0955 – volume: 5 start-page: 331 year: 1994 ident: 10.1016/j.bbagen.2015.02.008_bb1055 article-title: [MeIle4]Cyclosporin, a novel natural cyclosporin with anti-HIV activity: structural elucidation, biosynthesis and biological properties publication-title: Antivir. Chem. Chemother. doi: 10.1177/095632029400500507 – ident: 10.1016/j.bbagen.2015.02.008_bb1275 – ident: 10.1016/j.bbagen.2015.02.008_bb1250 – ident: 10.1016/j.bbagen.2015.02.008_bb0630 – ident: 10.1016/j.bbagen.2015.02.008_bb0785 – ident: 10.1016/j.bbagen.2015.02.008_bb1080 – volume: 10 start-page: 145 year: 1996 ident: 10.1016/j.bbagen.2015.02.008_bb0420 article-title: An unusual side chain C–C cleavage at the MeBmt amino acid in cyclosporin A publication-title: Amino Acids doi: 10.1007/BF00806587 – ident: 10.1016/j.bbagen.2015.02.008_bb0990 – ident: 10.1016/j.bbagen.2015.02.008_bb1290 – volume: 66 start-page: 807 year: 1991 ident: 10.1016/j.bbagen.2015.02.008_bb0175 article-title: Calcineurin is a common target of cyclophilin–cyclosporin A and FKBP-FK506 complexes publication-title: Cell doi: 10.1016/0092-8674(91)90124-H – ident: 10.1016/j.bbagen.2015.02.008_bb0625 – ident: 10.1016/j.bbagen.2015.02.008_bb0900 – volume: 6 start-page: 1127 year: 1998 ident: 10.1016/j.bbagen.2015.02.008_bb1135 article-title: Chemical genetics resulting from a passion for synthetic organic chemistry publication-title: Bioorg. Med. Chem. doi: 10.1016/S0968-0896(98)00126-6 – volume: 59 start-page: 1480 year: 1976 ident: 10.1016/j.bbagen.2015.02.008_bb0025 article-title: Crystal and molecular structure of an iodo-derivative of the cyclic undecapeptide cyclosporin A publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19760590509 – volume: 49 start-page: 191 year: 1997 ident: 10.1016/j.bbagen.2015.02.008_bb0240 article-title: Hydrolytic conditions for the formation of open-chain oligopeptides from cyclosporin A publication-title: J. Pept. Res. doi: 10.1111/j.1399-3011.1997.tb00877.x – volume: 30 start-page: 4215 year: 1989 ident: 10.1016/j.bbagen.2015.02.008_bb0450 article-title: A semi-synthetic approach to olefinic analogs of amino acid one (MeBmt) in cyclosporin A publication-title: Tetrahedron Lett. doi: 10.1016/S0040-4039(01)80693-6 – volume: 31 start-page: 173 year: 1998 ident: 10.1016/j.bbagen.2015.02.008_bb0425 article-title: Structural characterization of two novel oxidative derivatives of cyclosporine generated by a chemical method publication-title: Clin. Biochem. doi: 10.1016/S0009-9120(98)00014-9 – volume: 119 start-page: 1805 year: 1997 ident: 10.1016/j.bbagen.2015.02.008_bb1300 article-title: Cell-specific calcineurin inhibition by a modified cyclosporin publication-title: J. Am. Chem. Soc. doi: 10.1021/ja9636146 – ident: 10.1016/j.bbagen.2015.02.008_bb0565 – ident: 10.1016/j.bbagen.2015.02.008_bb0840 – volume: 13 start-page: 3157 year: 2005 ident: 10.1016/j.bbagen.2015.02.008_bb0360 article-title: Novel cyclosporin derivatives featuring enhanced skin penetration despite increased molecular weight publication-title: Bioorg. Med. Chem. doi: 10.1016/j.bmc.2005.02.049 – ident: 10.1016/j.bbagen.2015.02.008_bb0995 – ident: 10.1016/j.bbagen.2015.02.008_bb1075 – ident: 10.1016/j.bbagen.2015.02.008_bb0385 – ident: 10.1016/j.bbagen.2015.02.008_bb0660 – ident: 10.1016/j.bbagen.2015.02.008_bb1200 – ident: 10.1016/j.bbagen.2015.02.008_bb0905 – ident: 10.1016/j.bbagen.2015.02.008_bb0875 – ident: 10.1016/j.bbagen.2015.02.008_bb0720 – ident: 10.1016/j.bbagen.2015.02.008_bb1170 – volume: 91 start-page: 50 year: 2011 ident: 10.1016/j.bbagen.2015.02.008_bb0120 article-title: Treatment of autoimmune urticaria with low-dose cyclosporin A: a one-year follow-up publication-title: Acta Derm. Venereol. doi: 10.2340/00015555-0939 – volume: 185 start-page: 7663 year: 2010 ident: 10.1016/j.bbagen.2015.02.008_bb1175 article-title: A cell-impermeable cyclosporine A derivative reduces pathology in a mouse model of allergic lung inflammation publication-title: J. Immunol. doi: 10.4049/jimmunol.1001707 – ident: 10.1016/j.bbagen.2015.02.008_bb0405 – ident: 10.1016/j.bbagen.2015.02.008_bb0835 – volume: 20 start-page: 313 issue: 2, Suppl. 2 year: 1988 ident: 10.1016/j.bbagen.2015.02.008_bb1280 article-title: Cyclosporine: conformation and analogs as tools for studying its mechanism of action publication-title: Transplant. Proc. – ident: 10.1016/j.bbagen.2015.02.008_bb0495 – ident: 10.1016/j.bbagen.2015.02.008_bb0770 – volume: 42 start-page: 591 year: 1989 ident: 10.1016/j.bbagen.2015.02.008_bb1060 article-title: Cyclosporins—new analogs by precursor directed biosynthesis publication-title: J. Antibiot. doi: 10.7164/antibiotics.42.591 – ident: 10.1016/j.bbagen.2015.02.008_bb0510 – ident: 10.1016/j.bbagen.2015.02.008_bb0665 – ident: 10.1016/j.bbagen.2015.02.008_bb0940 – ident: 10.1016/j.bbagen.2015.02.008_bb1070 – volume: 3 start-page: 731 year: 1996 ident: 10.1016/j.bbagen.2015.02.008_bb0680 article-title: Controlling programmed cell death with cyclophilin–cyclosporin-based chemical inducer of dimerization publication-title: Chem. Biol. doi: 10.1016/S1074-5521(96)90249-5 – volume: 49 start-page: 781 year: 1996 ident: 10.1016/j.bbagen.2015.02.008_bb1040 article-title: Microbial biotransformation products of cyclosporin A publication-title: J. Antibiot. doi: 10.7164/antibiotics.49.781 – volume: 36 start-page: 633 year: 2001 ident: 10.1016/j.bbagen.2015.02.008_bb0255 article-title: Spontaneous N–O acyl shift in the [M+H]+ions of [MeBmt1]-cyclosporins in an ion trap publication-title: J. Mass Spectrom. doi: 10.1002/jms.163 – volume: 35 start-page: 6477 year: 1994 ident: 10.1016/j.bbagen.2015.02.008_bb0390 article-title: Preparation of functionalized ethers of cyclosporin A publication-title: Tetrahedron Lett. doi: 10.1016/S0040-4039(00)78250-5 – volume: 77 start-page: 291 year: 1994 ident: 10.1016/j.bbagen.2015.02.008_bb0055 article-title: Calorimetric measurements of the complexation of cyclosporin A, ascomycin, fujimycin, and rapamycin with lithium chloride and with an immunophilin publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19940770129 – volume: 38 start-page: 403 year: 1995 ident: 10.1016/j.bbagen.2015.02.008_bb0075 article-title: Cyclosporins from Tolypocladium terricola publication-title: Phytochemistry doi: 10.1016/0031-9422(94)00711-2 – volume: 60 start-page: 2610 year: 1995 ident: 10.1016/j.bbagen.2015.02.008_bb0415 article-title: Preparation of sulfhydryl cyclosporin A publication-title: J. Org. Chem. doi: 10.1021/jo00113a046 – volume: 41 start-page: 113 year: 2009 ident: 10.1016/j.bbagen.2015.02.008_bb0210 article-title: Mitochondria and reperfusion injury of the heart—a holey death but not beyond salvation publication-title: J. Bioenerg. Biomembr. doi: 10.1007/s10863-009-9206-x – volume: 268 start-page: F46 year: 1995 ident: 10.1016/j.bbagen.2015.02.008_bb1220 article-title: P-glycoprotein-mediated secretion of a fluorescent cyclosporin analog by teleost renal proximal tubules publication-title: Am. J. Physiol. – ident: 10.1016/j.bbagen.2015.02.008_bb0620 – ident: 10.1016/j.bbagen.2015.02.008_bb0945 – ident: 10.1016/j.bbagen.2015.02.008_bb0880 – volume: 55 start-page: 2895 year: 1990 ident: 10.1016/j.bbagen.2015.02.008_bb1285 article-title: Synthesis of D-lysine8-cyclosporine A. Further characterization of BOP-Cl in the 2–7 hexapeptide fragment synthesis publication-title: J. Org. Chem. doi: 10.1021/jo00296a061 – ident: 10.1016/j.bbagen.2015.02.008_bb0515 – volume: 26 start-page: 124 year: 2005 ident: 10.1016/j.bbagen.2015.02.008_bb0335 article-title: A water-soluble prodrug of cyclosporine A for ocular application: a stability study publication-title: Eur. J. Pharm. Sci. doi: 10.1016/j.ejps.2005.05.003 – volume: 49 start-page: 213 year: 2010 ident: 10.1016/j.bbagen.2015.02.008_bb1205 article-title: A cyclosporin derivative discriminates between extracellular and intracellular cyclophilins publication-title: Angew. Chem. Int. Ed. Engl. doi: 10.1002/anie.200904529 – start-page: 384 year: 2013 ident: 10.1016/j.bbagen.2015.02.008_bb0205 article-title: Optimization of cyclophilin inhibitors for use in antiviral therapy – volume: 60 start-page: 7455 year: 2004 ident: 10.1016/j.bbagen.2015.02.008_bb0730 article-title: How we drifted into peptide chemistry and where we have arrived at publication-title: Tetrahedron doi: 10.1016/j.tet.2004.06.043 – volume: 65 start-page: 1655 year: 1982 ident: 10.1016/j.bbagen.2015.02.008_bb0100 article-title: Isolation and structure determination of the new cyclosporins E, F, G, H and I publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19820650538 – ident: 10.1016/j.bbagen.2015.02.008_bb0300 – ident: 10.1016/j.bbagen.2015.02.008_bb0885 – volume: 3 start-page: 2559 year: 1993 ident: 10.1016/j.bbagen.2015.02.008_bb0700 article-title: Derivatives of cyclosporin at position 2 as probes for cyclophilin publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/S0960-894X(01)80716-2 – ident: 10.1016/j.bbagen.2015.02.008_bb0455 – volume: 24 start-page: 662 year: 2004 ident: 10.1016/j.bbagen.2015.02.008_bb0345 article-title: Water soluble cyclosporine monoethoxy poly(ethyleneglycol) conjugates as potential prodrugs publication-title: Arch. Pharm. Sci. Res. doi: 10.1007/BF02980167 – ident: 10.1016/j.bbagen.2015.02.008_bb1110 – ident: 10.1016/j.bbagen.2015.02.008_bb0535 – ident: 10.1016/j.bbagen.2015.02.008_bb1185 – volume: 2 start-page: 1621 year: 2010 ident: 10.1016/j.bbagen.2015.02.008_bb0190 article-title: Cyclophilin inhibitors as a novel HCV therapy publication-title: Viruses doi: 10.3390/v2081621 – ident: 10.1016/j.bbagen.2015.02.008_bb0810 – volume: 269 start-page: 14199 year: 1994 ident: 10.1016/j.bbagen.2015.02.008_bb1210 article-title: Mapping of the immunophilin-immunosuppressant site of interaction on calcineurin publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(17)36774-1 – volume: 57 start-page: 2689 year: 1992 ident: 10.1016/j.bbagen.2015.02.008_bb0675 article-title: Synthesis of the main metabolite (OL-17) of cyclosporin A publication-title: J. Org. Chem. doi: 10.1021/jo00035a027 – volume: 5 start-page: 724 year: 2009 ident: 10.1016/j.bbagen.2015.02.008_bb1190 article-title: Augmented photoswitching modulates immune signaling publication-title: Nat. Chem. Biol. doi: 10.1038/nchembio.214 – volume: 681 start-page: 539 year: 1993 ident: 10.1016/j.bbagen.2015.02.008_bb0130 article-title: A clinical therapeutic trial of cyclosporine in myasthenia gravis publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.1993.tb22937.x – ident: 10.1016/j.bbagen.2015.02.008_bb0650 – ident: 10.1016/j.bbagen.2015.02.008_bb0370 – ident: 10.1016/j.bbagen.2015.02.008_bb0735 – volume: 1 start-page: 536 year: 2010 ident: 10.1016/j.bbagen.2015.02.008_bb0635 article-title: Facile synthesis of a fluorescent cyclosporin A analogue to study cyclophilin 40 and cyclophilin 18 ligands publication-title: ACS Med. Chem. Lett. doi: 10.1021/ml1001272 – ident: 10.1016/j.bbagen.2015.02.008_bb0685 – ident: 10.1016/j.bbagen.2015.02.008_bb0960 – start-page: 381 year: 1994 ident: 10.1016/j.bbagen.2015.02.008_bb1130 article-title: Synthesis, structure and mechanism in immunophilin research publication-title: Synlett doi: 10.1055/s-1994-22863 – ident: 10.1016/j.bbagen.2015.02.008_bb0530 – ident: 10.1016/j.bbagen.2015.02.008_bb1115 – ident: 10.1016/j.bbagen.2015.02.008_bb0850 – volume: 5 start-page: 1006 year: 2004 ident: 10.1016/j.bbagen.2015.02.008_bb0930 article-title: Branches on the α-C atom of cyclosporin A residue 3 result in direct calcineurin inhibition and rapid cyclophilin 18 binding publication-title: ChemBioChem doi: 10.1002/cbic.200400020 – volume: vol. 7 start-page: 535 year: 1997 ident: 10.1016/j.bbagen.2015.02.008_bb0065 article-title: Cyclosporins: recent developments in biosynthesis, pharmacology and biology, and clinical applications – ident: 10.1016/j.bbagen.2015.02.008_bb0305 – volume: 8 start-page: 103 year: 2007 ident: 10.1016/j.bbagen.2015.02.008_bb0545 article-title: ISA 247: trans-ISA 247, trans-R 1524, ISA(TX)247, ISAtx 247, ISATx247, LX 211, LX211, R 1524, R-1524 publication-title: Drugs R&D doi: 10.2165/00126839-200708020-00005 – ident: 10.1016/j.bbagen.2015.02.008_bb0615 – volume: 60 start-page: 4868 year: 1995 ident: 10.1016/j.bbagen.2015.02.008_bb1240 article-title: Bridged cyclosporins publication-title: J. Org. Chem. doi: 10.1021/jo00120a034 – volume: 59 start-page: 1075 year: 1976 ident: 10.1016/j.bbagen.2015.02.008_bb0015 article-title: Cyclosporin A, a peptide metabolite from Trichoderma polysporun (Link ex Pers.) Rifai, with immunosuppressive activity publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19760590412 – volume: 76 start-page: 1564 year: 1993 ident: 10.1016/j.bbagen.2015.02.008_bb0045 article-title: Modification of cyclosporin A (CS): generation of an enolate at the sarcosine residue and reactions with electrophiles publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19930760415 – volume: 56 start-page: 7302 year: 2013 ident: 10.1016/j.bbagen.2015.02.008_bb0465 article-title: Anti-inflammatory effects of extracellular cyclosporins are exclusively mediated by CD147 publication-title: J. Med. Chem. doi: 10.1021/jm4007577 – ident: 10.1016/j.bbagen.2015.02.008_bb1065 – start-page: 173 year: 1996 ident: 10.1016/j.bbagen.2015.02.008_bb0235 – ident: 10.1016/j.bbagen.2015.02.008_bb1140 – volume: 38 start-page: 1853 year: 1995 ident: 10.1016/j.bbagen.2015.02.008_bb1165 article-title: Preparation and in vitro activities of ethers of [D-serine]8-cyclosporin publication-title: J. Med. Chem. doi: 10.1021/jm00011a004 – ident: 10.1016/j.bbagen.2015.02.008_bb0610 – ident: 10.1016/j.bbagen.2015.02.008_bb0765 – ident: 10.1016/j.bbagen.2015.02.008_bb0250 – volume: 25 start-page: 110 year: 1997 ident: 10.1016/j.bbagen.2015.02.008_bb0225 article-title: 1H NMR Analysis of isocyclosporin A prepared in organic solvent and in aqueous solution publication-title: Bioorg. Chem. doi: 10.1006/bioo.1997.1058 – volume: 6 start-page: 4358 year: 2000 ident: 10.1016/j.bbagen.2015.02.008_bb0710 article-title: Pseudoprolines (ΨPro) in drug design: direct insertion of ΨPro systems into cyclosporin C publication-title: Chem. Eur. J. doi: 10.1002/1521-3765(20001201)6:23<4358::AID-CHEM4358>3.0.CO;2-W – ident: 10.1016/j.bbagen.2015.02.008_bb0845 – ident: 10.1016/j.bbagen.2015.02.008_bb1230 – ident: 10.1016/j.bbagen.2015.02.008_bb0935 – ident: 10.1016/j.bbagen.2015.02.008_bb0505 – volume: 36 start-page: 3757 year: 1993 ident: 10.1016/j.bbagen.2015.02.008_bb0030 article-title: Solvent-dependent conformation and hydrogen-bonding capacity of cyclosporin A: evidence from partition coefficients and molecular dynamics simulations publication-title: J. Med. Chem. doi: 10.1021/jm00076a002 – volume: 12 start-page: 129 year: 2001 ident: 10.1016/j.bbagen.2015.02.008_bb0570 article-title: Modification of cyclosporin A and conjugation of its derivative to HPMA copolymers publication-title: Bioconjug. Chem. doi: 10.1021/bc000080w – volume: 852 start-page: 345 year: 2007 ident: 10.1016/j.bbagen.2015.02.008_bb1035 article-title: Determination of ciclosporin A and its six main metabolites in isolated T-lymphocytes and whole blood using liquid chromatography-tandem mass spectrometry publication-title: J. Chromatogr. B Anal. Technol. Biomed. Life Sci. doi: 10.1016/j.jchromb.2007.01.039 – volume: 46 start-page: 674 year: 2003 ident: 10.1016/j.bbagen.2015.02.008_bb0590 article-title: Synthesis and biological evaluation of novel cyclosporin A analogues: potential soft drugs for the treatment of autoimmune diseases publication-title: J. Med. Chem. doi: 10.1021/jm025595i – ident: 10.1016/j.bbagen.2015.02.008_bb0890 – volume: 49 start-page: 966 year: 2001 ident: 10.1016/j.bbagen.2015.02.008_bb0135 article-title: Low dose cyclosporine-A therapy in severe aplastic anaemia publication-title: J. Assoc. Physicians India – ident: 10.1016/j.bbagen.2015.02.008_bb0460 – volume: 27 start-page: 1624 year: 1988 ident: 10.1016/j.bbagen.2015.02.008_bb0725 article-title: Structure and reactivity of lithium enolates. from pinacolone to selective C-alkylations of peptides. Difficulties and opportunities afforded by complex structures publication-title: Angew. Chem. Int. Ed. Engl. doi: 10.1002/anie.198816241 – volume: 38 start-page: 1 year: 1986 ident: 10.1016/j.bbagen.2015.02.008_bb0010 article-title: Ciclosporin. Forward publication-title: Prog. Allergy – ident: 10.1016/j.bbagen.2015.02.008_bb0500 – start-page: 2935 year: 2009 ident: 10.1016/j.bbagen.2015.02.008_bb0575 article-title: Novel oxidation of cyclosporin A: preparation of cyclosporin methyl vinyl ketone (Cs-MVK) publication-title: Synlett – ident: 10.1016/j.bbagen.2015.02.008_bb0330 – volume: 59 start-page: 5241 year: 2003 ident: 10.1016/j.bbagen.2015.02.008_bb1100 article-title: Synthesis and characterization of constrained cyclosporin A derivatives containing a psuedo-proline group publication-title: Tetrahedron doi: 10.1016/S0040-4020(03)00770-1 – ident: 10.1016/j.bbagen.2015.02.008_bb0485 – volume: 45 start-page: 4613 year: 2002 ident: 10.1016/j.bbagen.2015.02.008_bb0085 article-title: Cyclosporins: structure–activity relationships for the inhibition of the human FPR1 formylpeptide receptor publication-title: J. Med. Chem. doi: 10.1021/jm010987v – ident: 10.1016/j.bbagen.2015.02.008_bb0655 – volume: 58 start-page: 673 year: 1993 ident: 10.1016/j.bbagen.2015.02.008_bb0270 article-title: Preparation of [D-Cysteine]8-cyclosporin via intramolecular sulfur transfer reaction publication-title: J. Org. Chem. doi: 10.1021/jo00055a020 – volume: 82 start-page: 279 year: 1997 ident: 10.1016/j.bbagen.2015.02.008_bb0070 article-title: Biosynthesis of cyclosporins publication-title: Drugs Pharm. Sci. doi: 10.1201/b14856-10 – ident: 10.1016/j.bbagen.2015.02.008_bb1095 – volume: 32 start-page: 492 year: 1986 ident: 10.1016/j.bbagen.2015.02.008_bb0705 article-title: Use of 125I-labeled-histamine–cyclosporin C for monitoring serum cyclosporine concentrations in transplantation patients publication-title: Clin. Chem. doi: 10.1093/clinchem/32.3.492 – ident: 10.1016/j.bbagen.2015.02.008_bb1255 – ident: 10.1016/j.bbagen.2015.02.008_bb0480 – ident: 10.1016/j.bbagen.2015.02.008_bb0365 – volume: 173 start-page: 619 year: 1991 ident: 10.1016/j.bbagen.2015.02.008_bb0445 article-title: Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A? publication-title: J. Exp. Med. doi: 10.1084/jem.173.3.619 – volume: 34 start-page: 505 year: 1994 ident: 10.1016/j.bbagen.2015.02.008_bb0060 article-title: Effect of temperature on molecular structure of cyclosporin A publication-title: Biochem. Mol. Biol. Int. – ident: 10.1016/j.bbagen.2015.02.008_bb0795 – ident: 10.1016/j.bbagen.2015.02.008_bb0310 – volume: 47 start-page: 407 year: 2004 ident: 10.1016/j.bbagen.2015.02.008_bb0645 article-title: Synthesis of tritiated Cyclosporin A and FK-506 by metal-catalyzed hydrogen isotope exchange publication-title: J. Label. Compd. Radiopharm. doi: 10.1002/jlcr.827 – ident: 10.1016/j.bbagen.2015.02.008_bb1005 – volume: 48 start-page: 6268 year: 2009 ident: 10.1016/j.bbagen.2015.02.008_bb0170 article-title: Isoform-specific inhibition of cyclophilins publication-title: Biochemistry doi: 10.1021/bi9007287 – volume: 93 start-page: 1583 year: 2010 ident: 10.1016/j.bbagen.2015.02.008_bb1120 article-title: Stereoselective Synthesis of [5-[4,4,4,4′,4′,4′-Hexafluoro-N-(2-hydroxyethoxy)-D-valine]]- and [5-[4,4,4,4′,4′,4′-Hexafluoro-N-(2-hydroxyethoxy)-L-valine]cyclosporin A publication-title: Helv. Chim. Acta doi: 10.1002/hlca.201000175 – volume: 80 start-page: 363 year: 1991 ident: 10.1016/j.bbagen.2015.02.008_bb0260 article-title: Synthesis of a fluorescent derivative of cyclosporin A for high-performance liquid chromatography analysis publication-title: J. Pharm. Sci. doi: 10.1002/jps.2600800416 – ident: 10.1016/j.bbagen.2015.02.008_bb0740 – ident: 10.1016/j.bbagen.2015.02.008_bb0820 – ident: 10.1016/j.bbagen.2015.02.008_bb0805 – volume: 68 start-page: 682 year: 1985 ident: 10.1016/j.bbagen.2015.02.008_bb0020 article-title: Peptide conformations. Part 31. The conformation of cyclosporin A in the crystal and in solution publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19850680319 – ident: 10.1016/j.bbagen.2015.02.008_bb0695 – ident: 10.1016/j.bbagen.2015.02.008_bb0970 – volume: 205 start-page: 65 year: 1992 ident: 10.1016/j.bbagen.2015.02.008_bb1235 article-title: Fluorescence displacement method for the determination of receptor-ligand binding constants publication-title: Anal. Biochem. doi: 10.1016/0003-2697(92)90579-V – volume: 11 start-page: 3 year: 2000 ident: 10.1016/j.bbagen.2015.02.008_bb0440 article-title: Synthesis of bioadhesive lectin–HMPA copolymer–cyclosporin conjugates publication-title: Bioconjug. Chem. doi: 10.1021/bc990098a – volume: 13 start-page: 136 year: 1992 ident: 10.1016/j.bbagen.2015.02.008_bb0180 article-title: The mechanism of action of cyclosporin A and FK506 publication-title: Immunol. Today doi: 10.1016/0167-5699(92)90111-J – ident: 10.1016/j.bbagen.2015.02.008_bb1105 – volume: 6 start-page: 890 year: 2005 ident: 10.1016/j.bbagen.2015.02.008_bb0555 article-title: Exo-mechanism proximity-accelerated alkylations: investigations of linkers, electrophiles and surface mutations in engineered cyclophilin–cyclosporin systems publication-title: ChemBioChem doi: 10.1002/cbic.200400383 – ident: 10.1016/j.bbagen.2015.02.008_bb0605 – volume: 5 start-page: 187 year: 1997 ident: 10.1016/j.bbagen.2015.02.008_bb0050 article-title: Conformational control of cyclosporin through substitution of the N-5 position. A new class of cyclosporin antagonists publication-title: Bioorg. Med. Chem. doi: 10.1016/S0968-0896(96)00204-0 – ident: 10.1016/j.bbagen.2015.02.008_bb0790 – ident: 10.1016/j.bbagen.2015.02.008_bb0745 – volume: 60 start-page: 1247 year: 1977 ident: 10.1016/j.bbagen.2015.02.008_bb0090 article-title: The structure of cyclosporin C publication-title: Helv. Chim. Acta doi: 10.1002/hlca.19770600414 – volume: 152 start-page: 597 year: 2005 ident: 10.1016/j.bbagen.2015.02.008_bb0110 article-title: Traditional therapies in the management of moderate to severe chronic plaque psoriasis: an assessment of the benefits and risks publication-title: Br. J. Dermatol. doi: 10.1111/j.1365-2133.2005.06563.x – volume: 17 start-page: 181 year: 2001 ident: 10.1016/j.bbagen.2015.02.008_bb0115 article-title: Review: uveitis and immunosuppressive drugs publication-title: J. Ocul. Pharmacol. Ther. doi: 10.1089/10807680151125537 – ident: 10.1016/j.bbagen.2015.02.008_bb0265 – ident: 10.1016/j.bbagen.2015.02.008_bb0540 – ident: 10.1016/j.bbagen.2015.02.008_bb1195 – volume: 51 start-page: 4226 year: 1991 ident: 10.1016/j.bbagen.2015.02.008_bb0410 article-title: In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833 publication-title: Cancer Res. – ident: 10.1016/j.bbagen.2015.02.008_bb0755 – ident: 10.1016/j.bbagen.2015.02.008_bb0325 – ident: 10.1016/j.bbagen.2015.02.008_bb0600 – volume: 57 start-page: 8503 year: 2014 ident: 10.1016/j.bbagen.2015.02.008_bb1020 article-title: Potent nonimmunosuppressive cyclophilin inhibitors with improved pharmaceutical properties and decreased transporter inhibition publication-title: J. Med. Chem. doi: 10.1021/jm500862r – ident: 10.1016/j.bbagen.2015.02.008_bb1150 – ident: 10.1016/j.bbagen.2015.02.008_bb0860 – ident: 10.1016/j.bbagen.2015.02.008_bb0925 – volume: 8 start-page: 5247 year: 2006 ident: 10.1016/j.bbagen.2015.02.008_bb0595 article-title: Synthesis, characterization, and utility of thermoresponsive natural/unnatural product macroligands for affinity chromatography publication-title: Org. Lett. doi: 10.1021/ol062045w – volume: 46 start-page: 775 year: 2009 ident: 10.1016/j.bbagen.2015.02.008_bb0215 article-title: A CaPful of mechanisms regulating the mitochondrial permeability transition publication-title: J. Mol. Cell. Cardiol. doi: 10.1016/j.yjmcc.2009.03.006 – volume: 41 start-page: 7193 year: 2000 ident: 10.1016/j.bbagen.2015.02.008_bb0950 article-title: Synthetic routes to NEtXaa4-cyclosporin A derivatives as potential anti-HIV I drugs publication-title: Tetrahedron Lett. doi: 10.1016/S0040-4039(00)01267-3 – volume: 99 start-page: 390 year: 2005 ident: 10.1016/j.bbagen.2015.02.008_bb1295 article-title: Production of human metabolites of cyclosporin A, AM1, AM4N and AM9, by microbial conversion publication-title: J. Biosci. Bioeng. doi: 10.1263/jbb.99.390 – start-page: 63 year: 2012 ident: 10.1016/j.bbagen.2015.02.008_bb0295 article-title: Organozirconium chemistry on cyclosporin: a novel process for the highly stereoselective synthesis of (E)-ISA247 (voclosporin) and close analogues publication-title: Synthesis – ident: 10.1016/j.bbagen.2015.02.008_bb0855 – volume: 59 start-page: 7249 year: 1994 ident: 10.1016/j.bbagen.2015.02.008_bb1030 article-title: Cyclosporin A: regioselective ring opening and fragmentation reactions via thioamides. A route to semisynthetic cyclosporins publication-title: J. Org. Chem. doi: 10.1021/jo00103a015 – volume: 11 start-page: 421 year: 2011 ident: 10.1016/j.bbagen.2015.02.008_bb1180 article-title: Effects of cyclosporine A and it immunosuppressive or non-immunosuppressive derivatives [D-Ser]8-CsA and Cs9 on mitochondria from different brain regions publication-title: Mitochondrion doi: 10.1016/j.mito.2010.12.012 – volume: 13 start-page: 4415 year: 2003 ident: 10.1016/j.bbagen.2015.02.008_bb0895 article-title: Synthesis of non-immunosuppressive cyclophilin-binding cyclosporin A derivatives as potential anti-HIV-1 drugs publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2003.09.042 – ident: 10.1016/j.bbagen.2015.02.008_bb1045 – volume: 356 start-page: 100 year: 2006 ident: 10.1016/j.bbagen.2015.02.008_bb0280 article-title: A fluorescence polarization-based assay for peptidyl prolyl cis/trans isomerase cyclophilin A publication-title: Anal. Biochem. doi: 10.1016/j.ab.2006.04.040 – ident: 10.1016/j.bbagen.2015.02.008_bb1260 – volume: 5 start-page: 2735 year: 1995 ident: 10.1016/j.bbagen.2015.02.008_bb0220 article-title: Structural factors affecting the kinetics of O, N-acyl transfer in potential O-peptide prodrugs publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/0960-894X(95)00454-2 – ident: 10.1016/j.bbagen.2015.02.008_bb0815 – ident: 10.1016/j.bbagen.2015.02.008_bb0475 – ident: 10.1016/j.bbagen.2015.02.008_bb0750 – ident: 10.1016/j.bbagen.2015.02.008_bb1000 – ident: 10.1016/j.bbagen.2015.02.008_bb1090 – volume: 23 start-page: 4485 year: 2013 ident: 10.1016/j.bbagen.2015.02.008_bb0200 article-title: Cyclophilin inhibitors as antiviral agents publication-title: Bioorg. Med. Chem. Lett. doi: 10.1016/j.bmcl.2013.05.101 – ident: 10.1016/j.bbagen.2015.02.008_bb0920 – volume: 2 start-page: 65 year: 2007 ident: 10.1016/j.bbagen.2015.02.008_bb0185 article-title: Role of cyclophilin A in HIV replication publication-title: Futur. Virol. doi: 10.2217/17460794.2.1.65 – volume: 24 start-page: 77 year: 1985 ident: 10.1016/j.bbagen.2015.02.008_bb0035 article-title: Synthesis of cyclosporine and analogues: structural requirements for immunosuppressive activity publication-title: Angew. Chem. Int. Ed. Engl. doi: 10.1002/anie.198500773 – volume: 262 start-page: 17258 year: 1987 ident: 10.1016/j.bbagen.2015.02.008_bb1145 article-title: Enzymic synthesis of cyclosporin A publication-title: J. Biol. Chem. doi: 10.1016/S0021-9258(18)45369-0 – volume: 57 start-page: 7145 year: 2014 ident: 10.1016/j.bbagen.2015.02.008_bb0195 article-title: From chemical tools to clinical medicines: nonimmunosuppressive cyclophilin inhibitors derived from the cyclosporin and sanglifehrin scaffolds publication-title: J. Med. Chem. doi: 10.1021/jm500223x – ident: 10.1016/j.bbagen.2015.02.008_bb0580 – volume: 9 start-page: 822 year: 2005 ident: 10.1016/j.bbagen.2015.02.008_bb0375 article-title: A practical method for the synthesis of a cyclosporine–fluorescein conjugate publication-title: Org. Process Res. Dev. doi: 10.1021/op0501592 |
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| Snippet | Since its isolation in 1970, and discovery of its potent inhibitory activity on T-cell proliferation, cyclosporin A (CsA) has been shown to play a significant... |
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| SubjectTerms | amino acids anions bioactive properties biologists catalysts Cyclic peptide Cyclophilin Cyclosporine Cyclosporins - chemical synthesis Cyclosporins - chemistry Humans olefin Semi-synthesis stereochemistry T-lymphocytes |
| Title | Semi-synthesis of cyclosporins |
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