Acetylcholinesterase inhibitory activity of stigmasterol & hexacosanol is responsible for larvicidal and repellent properties of Chromolaena odorata

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 3; pp. 541 - 550
• Main Authors: Gade, Sriramya, Rajamanikyam, Maheshwari, Vadlapudi, Varahalarao, Nukala, Krishna Madhav, Aluvala, Rajendar, Giddigari, Chandrasekhar, Karanam, Naga Jyothi, Barua, Nabin C., Pandey, Richa, Upadhyayula, Vijaya Saradhi V., Sripadi, Prabhakar, Amanchy, Ramars, Upadhyayula, Suryanarayana Murty
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2017
• Subjects: 1-Hexacosanol; Acetylcholinesterase; Acetylcholinesterase - metabolism; Aedes; Aedes - drug effects; Aedes - metabolism; Animals; bioactive compounds; Cholinesterase Inhibitors - pharmacology; chromatography; Chromolaena - chemistry; Chromolaena odorata; Culex quinquefasciatus; EAG; electroantennography; electrophysiology; Fatty Alcohols - pharmacology; insect repellents; Insecticides - pharmacology; Larva - drug effects; larvae; Larvicide; larvicides; mechanism of action; mortality; mosquito control; neurophysiology; neurotoxicity; Neurotoxins - pharmacology; nuclear magnetic resonance spectroscopy; Phytosterol; Phytosterols - pharmacology; plant extracts; Plant Extracts - pharmacology; Plant Leaves - chemistry; Stigmasterol; Stigmasterol - pharmacology; vector control; Stigmasterol; Stigmasterol (PubChem CID: 5280794); 1-Hexacosanol (PubChem CID: 68171); Phytosterol; 1-Hexacosanol; EAG; Larvicide; Acetylcholinesterase

Chromolaena odorata, has been traditionally known for its insect repellent property. Aim of this study was to determine larvicidal tendency of C. odorata on Culex quinquefasciatus and isolate compounds responsible for this activity and to determine the mechanism of action of these compounds. C. odor...