Suppression of endoplasmic reticulum stress reverses hindlimb unloading-induced hepatic cellular processes in mice

• Published in: Biochimica et biophysica acta. General subjects Vol. 1867; no. 9; p. 130422
• Main Authors: Ranade, Anu, Khan, Amir Ali, Gul, Muhammad Tehsil, Suresh, Savitha, Qaisar, Rizwan, Ahmad, Firdos, Karim, Asima
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2023
• Subjects: 4-phenyl butyrate; animal models; atrophy; cytochrome P-450; endoplasmic reticulum; Endoplasmic reticulum stress; gene ontology; genome; hindlimbs; Hindlimbs unloading; homeostasis; Liver; liver cirrhosis; males; mice; microgravity; 4-phenyl butyrate; Hindlimbs unloading; Liver; Endoplasmic reticulum stress

The Hindlimb unloaded mouse, an animal model of simulated microgravity demonstrates significant metabolic and hepatic derangements. However, cellular and molecular mechanisms driving liver dysfunction in Hindlimb unloaded mice are poorly characterized. We investigated the possible contribution of dy...