BBE31 from the Lyme disease agent Borrelia burgdorferi, known to play an important role in successful colonization of the mammalian host, shows the ability to bind glutathione

• Published in: Biochimica et biophysica acta. General subjects Vol. 1864; no. 3; p. 129499
• Main Authors: Brangulis, Kalvis, Akopjana, Inara, Petrovskis, Ivars, Kazaks, Andris, Zelencova, Diana, Jekabsons, Atis, Jaudzems, Kristaps, Tars, Kaspars
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2020
• Subjects: BbCRASP-1 fold; blood; Borrelia burgdorferi; Borrelia spielmanii; chemical bonding; crystal structure; genes; glutathione; hematophagy; hemolymph; Ixodes scapularis; Ixodes ticks; Lyme disease; mammals; mass spectrometry; Orthologous proteins; Outer surface protein; Protein glutathionylation; salivary glands; surface proteins; ticks; Ixodes ticks; Orthologous proteins; Protein glutathionylation; BbCRASP-1 fold; Outer surface protein

Lyme disease is a tick-borne infection caused by Borrelia burgdorferi sensu lato complex spirochetes. The spirochete is located in the gut of the tick; as the infected tick starts the blood meal, the spirochete must travel through the hemolymph to the salivary glands, where it can spread to and infe...