N-glycan and Alzheimer's disease

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 10; pp. 2447 - 2454
• Main Authors: Kizuka, Yasuhiko, Kitazume, Shinobu, Taniguchi, Naoyuki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2017
• Subjects: Alzheimer disease; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; amyloid; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Amyloid Precursor Protein Secretases - genetics; Amyloid Precursor Protein Secretases - metabolism; APP; BACE1; biomarkers; Bisecting GlcNAc; Carbohydrate Sequence; clinical trials; drugs; epitopes; glycomics; glycoproteins; Glycosylation; GnT-III; Humans; Membrane Glycoproteins - genetics; Membrane Glycoproteins - metabolism; N-glycan; Neprilysin - genetics; Neprilysin - metabolism; pathogenesis; Polysaccharides - chemistry; Polysaccharides - metabolism; Protein Processing, Post-Translational; Proteolysis; Receptors, Immunologic - genetics; Receptors, Immunologic - metabolism; Signal Transduction; sugars; tau Proteins - genetics; tau Proteins - metabolism; therapeutics; APP; ST6GAL1; AD; DAP12; PSEN; TREM2; Bisecting GlcNAc; GnT-III; BACE1; Aβ; TMEM59; N-glycan; APOE; sAPP; NFT; Alzheimer's disease
• ISSN: 0304-4165; 1872-8006
• DOI: 10.1016/j.bbagen.2017.04.012

Alzheimer's disease (AD) is a major form of dementia. Many evidence-based clinical trials have been performed, but no effective treatment has yet been developed. This suggests that our understanding of AD patho-mechanisms is still insufficient. In particular, the pathological roles of posttrans...