Effect of DNA bending on transcriptional interference in the systems of closely spaced convergent promoters

• Published in: Biochimica et biophysica acta Vol. 1860; no. 10; pp. 2086 - 2096
• Main Authors: Koroleva, Olga N., Dubrovin, Evgeniy V., Yaminsky, Igor V., Drutsa, Valeriy L.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2016
• Subjects: Atomic force microscopy; Convergent transcription; DNA structure; DNA, Circular - genetics; DNA, Circular - ultrastructure; DNA-Binding Proteins - genetics; DNA-directed RNA polymerase; DNA-Directed RNA Polymerases - genetics; DNA-Directed RNA Polymerases - ultrastructure; E. coli RNA polymerase; Escherichia coli - genetics; Escherichia coli - ultrastructure; gene expression; Microscopy, Atomic Force; Open promoter complexes; plasmids; Plasmids - genetics; Plasmids - ultrastructure; Promoter Regions, Genetic; RNA; transcription (genetics); Transcription Initiation Site; Transcription interference; Transcription, Genetic; DNA structure; Atomic force microscopy; Convergent transcription; E. coli RNA polymerase; Open promoter complexes; Transcription interference

Over the past years there are increasing evidences that the interplay between two molecules of RNA polymerases, initiating transcription from promoters, oriented in opposite (convergent) directions, can serve as a regulatory factor of gene expression. The data concerning the molecular mechanisms of...