A non-covalent “click chemistry” strategy to efficiently coat highly porous MOF nanoparticles with a stable polymeric shell

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 6; pp. 1606 - 1616
• Main Authors: Aykaç, Ahmet, Noiray, Magali, Malanga, Milo, Agostoni, Valentina, Casas-Solvas, Juan Manuel, Fenyvesi, Éva, Gref, Ruxandra, Vargas-Berenguel, Antonio
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2017
• Subjects: aqueous solutions; AZT-TP; beta-cyclodextrin; beta-Cyclodextrins - chemistry; biodegradability; byproducts; calorimetry; Calorimetry - methods; catalytic activity; Click Chemistry - methods; coatings; Drug Liberation; drugs; engineering; fluorescence emission spectroscopy; image analysis; iron; Iron Compounds - chemistry; Kinetics; Magnetics - methods; mannose; Mannose - analogs & derivatives; Mannose - chemistry; Metal Nanoparticles - chemistry; Microscopy, Confocal; MIL-100(Fe) nanoMOFs; nanoparticles; Nanotechnology - methods; Non-covalent coating; phosphates; Phosphorylation; polymers; Porosity; Rhodamines - chemistry; soaking; Solubility; Spectrometry, Fluorescence; Surface Properties; Thermodynamics; titration; toxicity; Zidovudine - chemistry; β-Cyclodextrin; polyCD; CD-P-R; Phosphorylation; MIL-100(Fe); MOF; AZT-TP; EP; CD-P-M; β-Cyclodextrin; β-CD; NMR; MIL-100(Fe) nanoMOFs; Non-covalent coating; ITC; DLC; CD-P; TEM

Metal-organic framework nanoparticles (nanoMOFs) are biodegradable highly porous materials with a remarkable ability to load therapeutic agents with a wide range of physico-chemical properties. Engineering the nanoMOFs surface may provide nanoparticles with higher stability, controlled release, and...