O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation

• Published in: Biochimica et biophysica acta. General subjects Vol. 1865; no. 8; p. 129930
• Main Authors: Xie, Xueqin, Wu, Qiutong, Zhang, Keren, Liu, Yimin, Zhang, Nana, Chen, Qiushi, Wang, Lingyan, Li, Wenli, Zhang, Jianing, Liu, Yubo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2021
• Subjects: Acetylglucosamine - chemistry; Acetylglucosamine - metabolism; angiogenesis; Apoptosis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast cancer; breast neoplasms; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; breasts; Cell Proliferation; Chromatin - chemistry; Chromatin - genetics; Chromatin - metabolism; chromatin immunoprecipitation; DNA Damage; gain-of-function mutation; gene expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; genes; Genotoxic adaptation; histones; Humans; mass spectrometry; MTA1; mutagens; N-Acetylglucosaminyltransferases - metabolism; neoplasm cells; nucleosomes; O-GlcNAc; Prognosis; Protein Processing, Post-Translational; proteomics; Repressor Proteins - chemistry; Repressor Proteins - genetics; Repressor Proteins - metabolism; serine; Survival Rate; Trans-Activators - chemistry; Trans-Activators - genetics; Trans-Activators - metabolism; transcription (genetics); transcriptomics; Tumor Cells, Cultured; Breast cancer; MTA1; O-GlcNAc; Genotoxic adaptation

Chromatin modifier metastasis-associated protein 1 (MTA1), closely associated with tumor angiogenesis in breast cancer, plays an important role in gene expression and cancer cell behavior. Recently, an association between O-GlcNAc transferase (OGT) and MTA1 was identified by mass spectroscopy. Howev...