FXII promotes proteolytic processing of the LRP1 ectodomain

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 8; pp. 2088 - 2098
• Main Authors: Wujak, Lukasz, Hesse, Christina, Sewald, Katherina, Jonigk, Danny, Braubach, Peter, Warnecke, Gregor, Fieguth, Hans-Gerd, Braun, Armin, Lochnit, Günter, Markart, Philipp, Schaefer, Liliana, Wygrecka, Malgorzata
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2017
• Subjects: blood coagulation; Coagulation factor XII; complement; Extracellular proteolysis; Factor XII - pharmacology; fibroblasts; Gelatinases - metabolism; Humans; hydrolysis; low density lipoprotein; Low Density Lipoprotein Receptor-Related Protein-1 - chemistry; Low-density lipoprotein receptor-related protein 1; macrophages; matrix-assisted laser desorption-ionization mass spectrometry; microbial collagenase; plasma membrane; Protein Domains; proteinase inhibitors; Proteolysis; serine proteinases; Low-density lipoprotein receptor-related protein 1; Extracellular proteolysis; Coagulation factor XII

Factor XII (FXII) is a serine protease that is involved in activation of the intrinsic blood coagulation, the kallikrein-kinin system and the complement cascade. Although the binding of FXII to the cell surface has been demonstrated, the consequence of this event for proteolytic processing of membra...