Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models

• Published in: Phytomedicine (Stuttgart) Vol. 129; p. 155616
• Main Authors: Li, Tian, Mao, Na, Xie, Zihao, Wang, Jianing, Jin, Fuyu, Li, Yaqian, Liu, Shupeng, Cai, Wenchen, Gao, Xuemin, Wei, Zhongqiu, Yang, Fang, Xu, Hong, Liu, Heliang, Zhang, Haibo, Xu, Dingjie
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.07.2024
• Subjects: animal models; bioinformatics; fibroblasts; gene expression; high performance liquid chromatography; histopathology; Inflammation; lungs; macrophages; mice; micro-computed tomography; Oriental traditional medicine; pulmonary fibrosis; silica; Silicosis; therapeutics; Traditional Chinese medicine; transcriptome; Western blotting; Yang-Yin-Qing-Fei Decoction; YYQFD; IL-17A; Traditional Chinese medicine; FN1; Inflammation; IL-1β; IL-6; MMP12; α-SMA; Yang-Yin-Qing-Fei Decoction; Col-I; PAI-1; Silicosis; HPLC; TCM

Silicosis presents a significant clinical challenges and economic burdens, with Traditional Chinese Medicine (TCM) emerging as a potential therapeutic avenue. However, the precise effects and mechanisms of TCM in treating silicosis remain uncertain and subject to debate. The study aims to elucidate...