Circular RNA expression profile of Alzheimer’s disease and its clinical significance as biomarkers for the disease risk and progression

• Published in: The international journal of biochemistry & cell biology Vol. 123; p. 105747
• Main Authors: Li, Yuanlong, Fan, Hua, Sun, Jun, Ni, Ming, Zhang, Lei, Chen, Ci, Hong, Xuejiao, Fang, Fengqin, Zhang, Wei, Ma, Peizhi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.06.2020
• Subjects: Aged; Alzheimer Disease - cerebrospinal fluid; Alzheimer Disease - genetics; Alzheimer’s disease; Amyloid beta-Peptides - cerebrospinal fluid; Amyloid beta-Peptides - genetics; Amyloid beta-Peptides - metabolism; biomarkers; Biomarkers - cerebrospinal fluid; cerebrospinal fluid; circular RNA; clinical significance; cytotoxicity; disease control; Disease Progression; Down-Regulation; expression profile; Female; Gene Ontology; Humans; Killer Cells, Natural - immunology; Logistic Models; Male; Microarray Analysis; microarray technology; MicroRNAs - cerebrospinal fluid; MicroRNAs - genetics; Middle Aged; mini-mental state examination score; natural killer cells; Nerve Growth Factors - cerebrospinal fluid; Nerve Growth Factors - genetics; Non-Neuronal Cholinergic System - genetics; Peptide Fragments - cerebrospinal fluid; Peptide Fragments - genetics; Peptide Fragments - metabolism; quantitative polymerase chain reaction; Real-Time Polymerase Chain Reaction; regression analysis; reverse transcription; reverse transcription quantitative polymerase chain reaction; risk; RNA, Circular - cerebrospinal fluid; RNA, Circular - genetics; ROC Curve; Signal Transduction - genetics; synapse; tau Proteins - cerebrospinal fluid; tau Proteins - genetics; tau Proteins - metabolism; Up-Regulation; miRNAs; AUC; SD; PNS; MMSE; circular RNA; SAMP8; CSF; KEGG; RT-qPCR; reverse transcription quantitative polymerase chain reaction; mini-mental state examination score; AD; Aβ42; Alzheimer’s disease; CI; ROC; GO; Ctrl; clinical significance; SAMR1; PCA; CircRNAs; FC; expression profile

To investigate circular RNA (circRNA) expression profile via microarray, and further assess the potential of candidate circRNAs as biomarkers in Alzheimer’s disease (AD). CircRNA expression profile in cerebrospinal fluid from 8 AD patients and 8 control (Ctrl) subjects was assessed by microarray. Su...