The balance between IL-12/IL4 in renal tissue switches the inflammatory response arm and shows relationship with the clinical signs in Leishmania-infected dogs

• Published in: Veterinary immunology and immunopathology Vol. 234; p. 110196
• Main Authors: Verçosa, Bárbara L.A., Muniz-Junqueira, Maria Imaculada, Menezes-Souza, Daniel, Fujiwara, Ricardo Toshio, Melo, Maria N., Vasconcelos, Anilton C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2021
• Subjects: Canine leishmaniosis; chi-square distribution; Cytokines; dogs; eosin; gene expression; immunopathology; Inflammation; interferon-gamma; interleukin-10; interleukin-12; interleukin-4; Kidney; kidneys; Leishmania; leishmaniasis; morphometry; pathogenesis; tumor necrosis factor-alpha; Inflammation; Cytokines; Canine leishmaniosis; Kidney

[Display omitted] •Renal inflammation in CanL is not associated with tissue infection by Leishmania.•Kidneys showed more inflammatory cells in the dogs that showed greater clinical signs.•The balance between IL-4 and IL-12 was critically determinant of the clinical signs (r = 0.70, Spearman test, p...