Valproate Attenuates Accelerated Atherosclerosis in Hyperglycemic ApoE-Deficient Mice

• Published in: The American journal of pathology Vol. 174; no. 1; pp. 330 - 342
• Main Authors: Bowes, Anna J, Khan, Mohammad I, Shi, Yuanyuan, Robertson, Lindsie, Werstuck, Geoff H
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 2009
• Subjects: Pathology

We have previously shown that glucosamine promotes endoplasmic reticulum (ER) stress in vascular cells leading to both inflammation and lipid accumulation—the hallmark features of atherosclerosis. Pretreatment with glycogen synthase kinase (GSK)-3 inhibitors protects cultured cells from ER stress-in...