Fatty acid synthase inhibitor orlistat induces apoptosis in T cell lymphoma: Role of cell survival regulatory molecules - Kant, Shiva; Kumar, Ajay; Singh, Sukh Mahendra (Biochimica et biophysica acta, 2012)
Keywords: animal models; Animals; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; caspase-3; Cell survival; Cell Survival - drug effects; cell viability; cytokines; Cytokines - biosynthesis; DNA fragmentation; Dose-Response Relationship, Drug; enzyme-linked immunosorbent assay; Fatty acid synthase; Fatty Acid Synthases - antagonists & inhibitors; fatty acids; fluorescence microscopy; gene expression; HSP70 Heat-Shock Proteins - physiology; interferon-gamma; Interferon-gamma - physiology; Lactones - pharmacology; Lymphoma, T-Cell - drug therapy; Lymphoma, T-Cell - pathology; Male; Mice; Mice, Inbred BALB C; neoplasm cells; Orlistat; proteins; reactive oxygen species; Reactive Oxygen Species - metabolism; reverse transcriptase polymerase chain reaction; T cell lymphoma; T-lymphocytes; Western blotting; NADPH; Cell survival; FASN; T cell lymphoma; ROS; DL; Orlistat; DCFDA; Fatty acid synthase; PUMA; CPT-1; Apoptosis