Graphical, Kinetic, and Equilibrium Analyses of in vivo [123I]β-CIT Binding to Dopamine Transporters in Healthy Human Subjects

• Published in: Journal of cerebral blood flow and metabolism Vol. 14; no. 6; pp. 982 - 994
• Main Authors: Laruelle, Marc, Wallace, Elizabeth, Seibyl, John P., Baldwin, Ronald M., Zea-Ponce, Yolanda, Zoghbi, Sami S., Neumeyer, John L., Charney, Dennis S., Hoffer, Paul B., Innis, Robert B.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.11.1994; Lippincott Williams & Wilkins
• Subjects: Adult; Biological and medical sciences; Brain - diagnostic imaging; Brain - metabolism; Carrier Proteins - metabolism; Cocaine - analogs & derivatives; Cocaine - blood; Cocaine - metabolism; Computer Simulation; Corpus Striatum - metabolism; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Iodine Radioisotopes; Kinetics; Male; Medical sciences; Membrane Glycoproteins; Membrane Transport Proteins; Miscellaneous; Models, Biological; Nerve Tissue Proteins - metabolism; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Pharmacology. Drug treatments; Reference Values; Time Factors; Tomography, Emission-Computed, Single-Photon; RTI-55; Dopamine transporter; Single-photon emission computed tomography; Parkinson's disease; 123I-Labeled 2β-carboxymethoxy-3β-(4-iodophenyl)tropane; Tracer kinetic model; Radionuclide study; Human; Dopamine; Pharmacokinetics; Emission tomography

The in vivo kinetics of the dopamine (DA) transporter probe 123I-labeled 2β-carboxymethoxy-3β-(4-iodophenyl)tropane ([123I]β-CIT) in striatum was investigated with single-photon emission computerized tomography (SPECT) in five healthy human subjects. The aim of this study was to derive an adequate m...