Lichen endophyte derived pyridoxatin inactivates Candida growth by interfering with ergosterol biosynthesis

• Published in: Biochimica et biophysica acta Vol. 1850; no. 9; pp. 1762 - 1771
• Main Authors: Chang, Wenqiang, Zhang, Ming, Li, Ying, Li, Xiaobin, Gao, Yanhui, Xie, Zhiyu, Lou, Hongxiang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2015
• Subjects: Antifungal Agents - pharmacology; antifungal properties; biofilm; biosynthesis; Caenorhabditis elegans; Candida; Candida - drug effects; Candida - metabolism; Candida albicans; cell cycle; Cell Cycle - drug effects; Cyclohexanes - pharmacology; cytotoxicity; endophytes; Endophytes - chemistry; Ergosterol; Ergosterol - biosynthesis; fungi; gene expression regulation; genes; growth retardation; Heterocyclic hydroxamic acid; humans; in vitro studies; in vivo studies; lanosterol; lichens; Lichens - microbiology; liquid chromatography; Microbial Sensitivity Tests; minimum inhibitory concentration; Pyridoxatin; quantitative polymerase chain reaction; squalene; Structure-Activity Relationship; structure-activity relationships; tandem mass spectrometry; transcription (genetics); transporters; Pyridoxatin; Ergosterol; Heterocyclic hydroxamic acid; Candida

This study is to characterize the antifungal effects of pyridoxatin (PYR), a small natural product isolated from an endolichenic fungus. The susceptibility tests in vitro and in vivo by using Caenorhabditis elegans as an infectious model were performed to evaluate the antifungal efficacy of PYR agai...