Cell stiffness determined by atomic force microscopy and its correlation with cell motility

• Published in: Biochimica et biophysica acta Vol. 1860; no. 9; pp. 1953 - 1960
• Main Authors: Luo, Qing, Kuang, Dongdong, Zhang, Bingyu, Song, Guanbin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2016
• Subjects: Animals; Atomic force microscopy; biomarkers; cell movement; Cell Movement - physiology; Cell Nucleus - physiology; Cytoskeleton; Cytoskeleton - physiology; Elastic Modulus - physiology; Humans; mechanical properties; metastasis; Microscopy, Atomic Force - methods; modulus of elasticity; Motility; neoplasm cells; neoplasms; Nuclear stiffness; Stiffness; Young's modulus; Atomic force microscopy; Young's modulus; Cytoskeleton; Stiffness; Motility; Nuclear stiffness

Cell stiffness is a crucial mechanical property that is closely related to cell motility. AFM is the most prevalent method used to determine cell stiffness by the quantitative parameter designated as Young's modulus. Young's modulus is regarded as a biomarker of cell motility, especially i...