Integrative genomic and network analysis identified novel genes associated with the development of advanced cervical squamous cell carcinoma

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 1; pp. 2899 - 2911
• Main Authors: Roychowdhury, Anirban, Samadder, Sudip, Das, Pijush, Mandloi, Sapan, Addya, Sankar, Chakraborty, Chandraditya, Basu, Partha Sarathi, Mondal, Ranajit, Roy, Anup, Chakrabarti, Saikat, Roychoudhury, Susanta, Panda, Chinmay Kumar
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2017
• Subjects: ATR; biochemical pathways; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - pathology; Cell Line, Tumor; Cervical cancer; Chromosomes, Human - genetics; Copy-number variations; data collection; DNA Copy Number Variations - genetics; DNA repair; Female; Gene Expression Regulation, Neoplastic; gene overexpression; Gene Regulatory Networks; genes; Genes, Neoplasm; Genomics; Humans; loci; microarray technology; Neoplasm Staging; PARP1; patients; Polymorphism, Single Nucleotide - genetics; prognosis; Protein Interaction Maps - genetics; Protein-protein interaction network; proteins; Reproducibility of Results; squamous cell carcinoma; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - pathology; women; Protein-protein interaction network; PARP1; CNVs; PPI; CGH-SNP; hrHPV; Copy-number variations; TCGA; Cervical cancer; CSCC; ATR

CSCC is one of the most common cancer affecting women globally. Though it is caused by the infection of hrHPV but long latency period for malignant outcome in only a subset of hrHPV infected women indicates involvement of additional alterations, primarily CNVs. Here, we showed how CNVs played a cruc...