Ebola virus derived G-quadruplexes: Thiazole orange interaction

• Published in: Biochimica et biophysica acta. General subjects Vol. 1861; no. 5; pp. 1321 - 1328
• Main Authors: Krafčíková, Petra, Demkovičová, Erika, Víglaský, Viktor
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2017
• Subjects: Benzothiazoles - chemistry; Benzothiazoles - metabolism; Binding Sites; Circular Dichroism; circular dichroism spectroscopy; DNA; DNA, Viral - chemistry; DNA, Viral - genetics; DNA, Viral - metabolism; Ebola virus; Ebolavirus; Ebolavirus - genetics; electrophoresis; Electrophoresis, Polyacrylamide Gel; Fluorescent Dyes - chemistry; Fluorescent Dyes - metabolism; G-quadruplex; G-Quadruplexes; Guanosine - chemistry; Guanosine - metabolism; Induced circular dichroism; Ligands; Marburg virus; Marburgvirus - genetics; Nucleic Acid Denaturation; nucleotide sequences; oligonucleotides; Oligonucleotides - chemistry; Oligonucleotides - genetics; Oligonucleotides - metabolism; Quinolines - chemistry; Quinolines - metabolism; researchers; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Temperature; Thiazole orange; thiazoles; topology; viruses; Ebola virus; Thiazole orange; EBOV; Marburg virus; G-quadruplex; Induced circular dichroism; TO; ICD; MARV

The Ebola and Marburg viruses are some of the deadliest viruses in the world. In this study a series of G-rich DNA sequences derived from these types of viruses which possess the potential to form G-quadruplex structures are analyzed. A set of DNA oligonucleotides derived from original viral isolate...