Omega-3 DHA- and EPA–dopamine conjugates induce PPARγ-dependent breast cancer cell death through autophagy and apoptosis

• Published in: Biochimica et biophysica acta Vol. 1850; no. 11; pp. 2185 - 2195
• Main Authors: Rovito, Daniela, Giordano, Cinzia, Plastina, Pierluigi, Barone, Ines, De Amicis, Francesca, Mauro, Loredana, Rizza, Pietro, Lanzino, Marilena, Catalano, Stefania, Bonofiglio, Daniela, Andò, Sebastiano
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2015
• Subjects: adjuvants; amines; antagonists; Apoptosis; Apoptosis - drug effects; Apoptosis Regulatory Proteins - genetics; Autophagy; Autophagy - drug effects; Beclin-1; bioactive properties; Breast cancer; breast neoplasms; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; chromatin; DNA damage; DNA fragmentation; docosahexaenoic acid; Docosahexaenoic Acids - pharmacology; Dopamine - pharmacology; eicosapentaenoic acid; Eicosapentaenoic Acid - pharmacology; epithelium; Female; Humans; immunoblotting; MCF-7 Cells; Membrane Proteins - genetics; neoplasm cells; Omega-3 polyunsaturated fatty acid conjugates; Peroxisome Proliferator-Activated Receptor gamma; PPAR gamma - physiology; precipitin tests; Promoter Regions, Genetic; RNA; viability; Beclin-1; Omega-3 polyunsaturated fatty acid conjugates; Breast cancer; Autophagy; Peroxisome Proliferator-Activated Receptor gamma; Apoptosis

The omega-3 docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) may form conjugates with amines that have potential health benefits against common diseases including cancers. Here we synthesized DHA-dopamine (DHADA) and EPA–dopamine (EPADA) conjugates and studied their biological effects on d...