The cytosolic isoform of glutaredoxin 2 promotes cell migration and invasion

• Published in: Biochimica et biophysica acta. General subjects Vol. 1864; no. 7; p. 129599
• Main Authors: Gellert, Manuela, Richter, Erik, Mostertz, Jörg, Kantz, Liane, Masur, Kai, Hanschmann, Eva-Maria, Ribback, Silvia, Kroeger, Nils, Schaeffeler, Elke, Winter, Stefan, Hochgräfe, Falko, Schwab, Matthias, Lillig, Christopher Horst
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2020
• Subjects: actin; cell adhesion; Cell Adhesion - physiology; cell culture; cell lines; Cell motility; cell movement; Cell Movement - physiology; collagen; cytoskeleton; Glutaredoxin; Glutaredoxins - chemistry; Humans; Invasiveness; isotope labeling; mass spectrometry; neoplasm cells; Neoplasms; phosphopeptides; phosphorylation; Protein Isoforms - metabolism; Redox regulation; Signal Transduction; stable isotopes; Glutaredoxin; Cell motility; Invasiveness; Redox regulation

Cytosolic glutaredoxin 2 (Grx2c) controls axonal outgrowth and is specifically induced in many cancer cell lines. We thus hypothesized that Grx2c promotes cell motility and invasiveness. We characterized the impact of Grx2c expression in cell culture models. We combined stable isotope labeling, phos...