Mitochondrial and endoplasmic reticulum pathways involved in microcystin-LR-induced apoptosis of the testes of male frog (Rana nigromaculata) in vivo

• Published in: Journal of hazardous materials Vol. 252-253; pp. 382 - 389
• Main Authors: Zhang, Hangjun, Cai, Chenchen, Wu, Yingzhu, Shao, Dandan, Ye, Binhui, Zhang, Yue, Liu, Jiayu, Wang, Jia, Jia, Xiuying
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 15.05.2013; Elsevier
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Applied sciences; bcl-2-Associated X Protein - metabolism; Caspases - metabolism; Chemical engineering; Cytochromes c - metabolism; Drinking water and swimming-pool water. Desalination; Endoplasmic Reticulum; Exact sciences and technology; Glutathione - metabolism; Glutathione Peroxidase - metabolism; Heat-Shock Proteins - metabolism; Male; Malondialdehyde - metabolism; MC-LR; Microcystins - toxicity; Microscopy, Electron, Transmission; Mitochondria; Oxidative Stress; Pollution; Proto-Oncogene Proteins c-bcl-2 - metabolism; Rana nigromaculata; Ranidae; Reactive Oxygen Species - metabolism; Reactors; Testis - drug effects; Testis - metabolism; Testis - ultrastructure; Transcription Factor CHOP - metabolism; Water Pollutants, Chemical - toxicity; Water treatment and pollution; MC-LR; Mitochondria; Rana nigromaculata; Endoplasmic reticulum; Apoptosis; Drinking water; Deformation; Toxicity; Antioxidant; In vitro; Toxin; Production; Oxidation

•MCLR can induce apoptosis on testes of Rana nigromaculata.•1μg/L MCLR (the drinking water standard level) has ecological risks on frogs.•MCLR induces frog testes apoptosis via oxidative stress.•MCLR-induced apoptosis on frog testes is associated with mitochondrial pathway.•Endoplasmic reticulum pat...