Screening of differentially methylated genes in skeletal fluorosis of rats with different types and involvement of aberrant methylation of Cthrc1

• Published in: Environmental pollution (1987) Vol. 332; p. 121931
• Main Authors: Ding, Hongwei, Yin, Congyu, Yang, Menglan, Zhou, Ruiqi, Wang, Xilan, Pan, Xueli
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2023
• Subjects: bisulfites; Cthrc1; Different nutrition; DNA methylation; fluorides; fluorosis; genes; homeostasis; methyltransferases; osteoblasts; osteoclasts; pollutants; pollution; protein synthesis; risk; Skeletal fluorosis; LN; RANKL; DNMT1; M-CSF; LNF; rBMSCs; mRNA-Seq; N; NaF; MC; DNA methylation; KEGG; Skeletal fluorosis; Cthrc1; OP; OS; TBS; rBMMs; Different nutrition; GO; TET2; DAPI; NC; TRACP; NF

Fluoride is a widespread pollutant in the environment. There is a high risk of developing skeletal fluorosis from excessive fluoride exposure. Skeletal fluorosis has different phenotypes (including osteosclerotic, osteoporotic and osteomalacic) under the same fluoride exposure and depends on dietary...