Activities of curcumin-related compounds in two cell lines persistently infected with different prion strains

• Published in: Biochimica et biophysica acta. General subjects Vol. 1866; no. 4; p. 130094
• Main Authors: Teruya, Kenta, Iwabuchi, Sara, Watanabe, Yuki, Tsuchida, Rikiya, Watanabe-Matsui, Miki, Konno, Hiroyuki, Doh-ura, Katsumi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2022
• Subjects: Anti-prion; Cell Line; chemometrics; Curcumin; Curcumin - pharmacology; dose response; hydrogen; hydrophobicity; Partial least squares; Prion; Prion Proteins; prions; Prions - chemistry; Prions - metabolism; Protein cross-linking; PrPSc Proteins - metabolism; F_unbound; PrPres; PrPSc; LP; DMSO; CNS; SA; Anti-prion; PLS; IC50; Curcumin; Partial least squares; Protein cross-linking; PBS; Acceptor; SDS; VDss; IR; MW; Rot_Bond; CNS_p; PrP; BBB_p; PrPC; Donor; Prion; PK; N2a; ATR

Cultured cell lines infected with prions produce an abnormal isoform of the prion protein (PrPSc). In this study, two types of cells persistently infected with prion were treated with curcumin-related compounds. We found that the compounds behave differently in neuroblastoma neuro-2a (N2a) cells inf...