Effects of high-fat overfeeding on mitochondrial function, glucose and fat metabolism, and adipokine levels in low-birth-weight subjects

• Published in: American journal of physiology: endocrinology and metabolism Vol. 302; no. 1; pp. E43 - E51
• Main Authors: Brøns, Charlotte, Jacobsen, Stine, Hiscock, Natalie, White, Andrew, Nilsson, Emma, Dunger, David, Astrup, Arne, Quistorff, Bjørn, Vaag, Allan
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.01.2012
• Subjects: Adenosine Triphosphate - metabolism; Adipokines - blood; Adult; Birth weight; Cross-Over Studies; Denmark - epidemiology; Diabetes Mellitus, Type 2 - etiology; Dietary Fats - adverse effects; Gastric Inhibitory Polypeptide - blood; Glucose; Glucose - metabolism; Hormones; Humans; Infant, Low Birth Weight; Infant, Newborn; Insulin Resistance; Leptin - blood; Lipid Metabolism; Male; Metabolism; Mitochondria; Mitochondria, Muscle - metabolism; Muscle, Skeletal - metabolism; Pancreatic Polypeptide - blood; Phosphocreatine - metabolism; Phosphorylation; Protein Precursors - blood; Registries; Young Adult; Denmark

Low birth weight (LBW) is associated with an increased risk of insulin resistance and downregulation of oxidative phosphorylation (OXPHOS) genes when exposed to a metabolic challenge of high-fat overfeeding (HFO). To elaborate further on the differential effects of HFO in LBW subjects, we measured i...