Structural basis of the signal transduction via transmembrane domain of the human growth hormone receptor

• Published in: Biochimica et biophysica acta Vol. 1862; no. 6; pp. 1410 - 1420
• Main Authors: Bocharov, Eduard V., Lesovoy, Dmitry M., Bocharova, Olga V., Urban, Anatoly S., Pavlov, Konstantin V., Volynsky, Pavel E., Efremov, Roman G., Arseniev, Alexander S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.06.2018
• Subjects: Alternative dimerization; cis-trans isomerism; dimerization; Growth hormone receptor; ligands; lipid bilayers; micelles; molecular dynamics; mutagenesis; NMR; nuclear magnetic resonance spectroscopy; proline; Protein-lipid interactions; signal transduction; somatotropin; somatotropin receptors; Spatial structure; Transmembrane domain; GHRtm; JM; D/P; RTK; Transmembrane domain; Alternative dimerization; ecJM; τR; GHR; MHP; HSQC-CT; MD; POPC; JAK2; NOE; LID; ECD; TMD; ICD; Spatial structure; TROSY; NMR; Growth hormone receptor; Protein-lipid interactions; DPC; HSQC

Prior studies of the human growth hormone receptor (GHR) revealed a distinct role of spatial rearrangements of its dimeric transmembrane domain in signal transduction across membrane. Detailed structural information obtained in the present study allowed elucidating the bases of such rearrangement an...