The mTORC2/PKC pathway sustains compensatory insulin secretion of pancreatic β cells in response to metabolic stress - Xie, Yun; Cui, Canqi; Nie, Aifang; Wang, Yan; Ni, Qicheng; Liu, Yun; Yin, Qinglei; Zhang, Hongli; Li, Yong; Wang, Qidi; Gu, Yanyun; Ning, Guang (Biochimica et biophysica acta. General subjects, 2017)
Keywords: Animals; calcium; capacitance; Diabetes Mellitus, Type 2 - etiology; Diet, High-Fat; electrophysiology; glucose; High-fat diet; insulin; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells - metabolism; islets of Langerhans; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Inbred C57BL; Mice, Knockout; mTORC2; Multiprotein Complexes - physiology; noninsulin-dependent diabetes mellitus; palmitates; pathogenesis; phosphorylation; PKC; protein kinase C; Protein Kinase C-alpha - physiology; proteins; Signal Transduction - physiology; Stress, Physiological - physiology; Tetradecanoylphorbol Acetate - pharmacology; TOR Serine-Threonine Kinases - physiology; Type 2 Diabetes; β cell; βRicKO; PMA; HM; Type 2 Diabetes; HFD; T2D; Rictor; PKC; β cell; GIIS; NCD; Insulin secretion; High-fat diet; mTOR; TM; mTORC2