Plant components can reduce methylmercury toxication: A mini-review

• Published in: Biochimica et biophysica acta. General subjects Vol. 1863; no. 12; p. 129290
• Main Authors: Chang, Jie, Zhou, Yun, Wang, Qiang, Aschner, Michael, Lu, Rongzhu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2019
• Subjects: absorption; Animals; biochemical mechanisms; demethylation; drugs; excretion; Humans; intestines; mercury; Methylmercury; methylmercury compounds; Methylmercury Compounds - pharmacokinetics; Methylmercury Compounds - toxicity; Natural plant components; nervous system; Neuroprotective Agents - chemistry; Neuroprotective Agents - pharmacokinetics; neurotoxicity; Neurotoxicity Syndromes - drug therapy; Neurotoxicity Syndromes - metabolism; Neurotoxicity Syndromes - pathology; plant extracts; Plant Extracts - chemistry; Plant Extracts - pharmacokinetics; Plant Extracts - therapeutic use; Plant Structures - chemistry; pollutants; protective effect; therapeutics; tissues; Toxicity; Cd; CDC; Toxicity; CNS; HO-1; MDA; UC; FFQ; LDH; bw; Nrf2; CGNs; Methylmercury; BME; GD; GSH; EpRE; Hg; DTPA; hNSCs; i.g; GEE; SOD; i.p; TBARS; Natural plant components; DMPS; BAL; GPx; MeHg; ARE; Trolox; CAT; LC; NMDA-R; ROS; LBPs; POEE; TP; ADA; DC

Methylmercury (MeHg) is a ubiquitous environmental pollutant, with the nervous system as its main target; however, the neurotoxic mechanisms of MeHg have not been fully elucidated, and no effective therapeutic and preventive drugs are available to mitigate its toxicity. Recent evidence suggests a re...