Ferritin heavy chain mediates the protective effect of heme oxygenase-1 against oxidative stress

• Published in: Biochimica et biophysica acta Vol. 1850; no. 12; pp. 2506 - 2517
• Main Authors: Cheng, Hui-Teng, Yen, Chung-Jen, Chang, Chen-Chih, Huang, Kuo-Tong, Chen, Kuo-Hsuan, Zhang, Rui-Yang, Lee, Ping-Yi, Miaw, Shi-Chuen, Huang, Jenq-Wen, Chiang, Chih-Kang, Wu, Kwan-Dun, Hung, Kuan-Yu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2015
• Subjects: Animals; antigens; Apoferritins - physiology; cell death; ferritin; Ferritin heavy chain; ferroxidase; Glomerular Mesangium - cytology; Glomerular Mesangium - metabolism; glomerulonephritis; heme oxygenase (biliverdin-producing); Heme oxygenase-1; Heme Oxygenase-1 - physiology; humans; hydrogen peroxide; Inflammation; iron; microarray technology; mutants; neutralization; Oxidative Stress; phosphorylation; protective effect; Rats; RNA interference; thymocytes; toxicity; transcription factors; Oxidative stress; Inflammation; Ferritin heavy chain; Heme oxygenase-1

The phenomenon that heme oxygenase-1 (HO-1) protects cell from injury yet its enzymatic product, iron, may facilitate generation of free radical has been long puzzling. Here we establish a functional connection between ferritin heavy chain (FHC) and HO-1. In human lupus nephritis HO-1 and FHC are co...