Fibrogenesis in Crohn's Disease

• Published in: The American journal of gastroenterology Vol. 102; no. 2; pp. 439 - 448
• Main Authors: BURKE, John P, MULSOW, Jurgen J, O'KEANE, Conor, DOCHERTY, Neil G, WATSON, R. William G, RONAN O'CONNELL, P
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell Publishing 01.02.2007; Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
• Subjects: Biological and medical sciences; Crohn Disease - complications; Crohn Disease - pathology; Disease Progression; Fibrosis - complications; Fibrosis - pathology; Gastroenterology; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Intestinal Obstruction - etiology; Intestinal Obstruction - pathology; Medical sciences; Other diseases. Semiology; Prognosis; Retrospective Studies; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Crohn disease; Digestive diseases; Intestinal disease; Inflammatory disease

Over one-third of patients with Crohn's disease (CD) will develop an intestinal stricture and the great majority of these will require at least one surgical procedure. While the pathogenesis of inflammation in CD has been extensively investigated, knowledge of stricture pathogenesis remains lim...