Fibrogenesis in Crohn's Disease

Over one-third of patients with Crohn's disease (CD) will develop an intestinal stricture and the great majority of these will require at least one surgical procedure. While the pathogenesis of inflammation in CD has been extensively investigated, knowledge of stricture pathogenesis remains lim...

Full description

Saved in:
Bibliographic Details
Published inThe American journal of gastroenterology Vol. 102; no. 2; pp. 439 - 448
Main Authors BURKE, John P, MULSOW, Jurgen J, O'KEANE, Conor, DOCHERTY, Neil G, WATSON, R. William G, RONAN O'CONNELL, P
Format Journal Article
LanguageEnglish
Published Oxford Blackwell Publishing 01.02.2007
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
Subjects
Biological and medical sciences
Crohn Disease - complications
Crohn Disease - pathology
Disease Progression
Fibrosis - complications
Fibrosis - pathology
Gastroenterology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Intestinal Obstruction - etiology
Intestinal Obstruction - pathology
Medical sciences
Other diseases. Semiology
Prognosis
Retrospective Studies
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Crohn disease
Digestive diseases
Intestinal disease
Inflammatory disease
Online AccessGet full text

Cover

Abstract Over one-third of patients with Crohn's disease (CD) will develop an intestinal stricture and the great majority of these will require at least one surgical procedure. While the pathogenesis of inflammation in CD has been extensively investigated, knowledge of stricture pathogenesis remains limited. The aim of this review is to discuss the current understanding of fibrogenesis in CD and to outline potential directions in research and therapeutics. The electronic literature (January 1966 to May 2006) on CD-associated fibrosis was reviewed. Further references were obtained by cross-referencing from key articles. CD-associated fibrosis results from chronic transmural inflammation and a complex interplay among intestinal mesenchymal cells, cytokines, and local inflammatory cells. The fibroblast is the key cell type mediating stricture formation. The cytoarchitecure of the bowel wall is altered with disruption of the muscularis mucosa, thickening of the muscularis propria, and deposition of collagen throughout. The cytokine TGF-beta appears critical in this process, acting to increase growth factor and extracellular matrix (ECM) production and dysregulate ECM turnover. Potential therapeutic interventions are likely to concentrate on modulating down-stream targets of TGF-beta. Greater understanding of the biology of fibrostenosis is likely to yield significant advances in our ability to care for patients with stricturing CD. Potential dividends of this approach include identification of novel therapeutic targets and biomarkers useful for prognostication and therapeutic monitoring.
AbstractList Over one-third of patients with Crohn's disease (CD) will develop an intestinal stricture and the great majority of these will require at least one surgical procedure. While the pathogenesis of inflammation in CD has been extensively investigated, knowledge of stricture pathogenesis remains limited. The aim of this review is to discuss the current understanding of fibrogenesis in CD and to outline potential directions in research and therapeutics. The electronic literature (January 1966 to May 2006) on CD-associated fibrosis was reviewed. Further references were obtained by cross-referencing from key articles. CD-associated fibrosis results from chronic transmural inflammation and a complex interplay among intestinal mesenchymal cells, cytokines, and local inflammatory cells. The fibroblast is the key cell type mediating stricture formation. The cytoarchitecure of the bowel wall is altered with disruption of the muscularis mucosa, thickening of the muscularis propria, and deposition of collagen throughout. The cytokine TGF-beta appears critical in this process, acting to increase growth factor and extracellular matrix (ECM) production and dysregulate ECM turnover. Potential therapeutic interventions are likely to concentrate on modulating down-stream targets of TGF-beta. Greater understanding of the biology of fibrostenosis is likely to yield significant advances in our ability to care for patients with stricturing CD. Potential dividends of this approach include identification of novel therapeutic targets and biomarkers useful for prognostication and therapeutic monitoring.
INTRODUCTION:Over one-third of patients with Crohn's disease (CD) will develop an intestinal stricture and the great majority of these will require at least one surgical procedure. While the pathogenesis of inflammation in CD has been extensively investigated, knowledge of stricture pathogenesis remains limited. The aim of this review is to discuss the current understanding of fibrogenesis in CD and to outline potential directions in research and therapeutics.METHODS:The electronic literature (January 1966 to May 2006) on CD-associated fibrosis was reviewed. Further references were obtained by cross-referencing from key articles.RESULTS:CD-associated fibrosis results from chronic transmural inflammation and a complex interplay among intestinal mesenchymal cells, cytokines, and local inflammatory cells. The fibroblast is the key cell type mediating stricture formation. The cytoarchitecure of the bowel wall is altered with disruption of the muscularis mucosa, thickening of the muscularis propria, and deposition of collagen throughout. The cytokine TGF-β appears critical in this process, acting to increase growth factor and extracellular matrix (ECM) production and dysregulate ECM turnover. Potential therapeutic interventions are likely to concentrate on modulating down-stream targets of TGF-β.CONCLUSIONS:Greater understanding of the biology of fibrostenosis is likely to yield significant advances in our ability to care for patients with stricturing CD. Potential dividends of this approach include identification of novel therapeutic targets and biomarkers useful for prognostication and therapeutic monitoring.
INTRODUCTIONOver one-third of patients with Crohn's disease (CD) will develop an intestinal stricture and the great majority of these will require at least one surgical procedure. While the pathogenesis of inflammation in CD has been extensively investigated, knowledge of stricture pathogenesis remains limited. The aim of this review is to discuss the current understanding of fibrogenesis in CD and to outline potential directions in research and therapeutics.METHODSThe electronic literature (January 1966 to May 2006) on CD-associated fibrosis was reviewed. Further references were obtained by cross-referencing from key articles.RESULTSCD-associated fibrosis results from chronic transmural inflammation and a complex interplay among intestinal mesenchymal cells, cytokines, and local inflammatory cells. The fibroblast is the key cell type mediating stricture formation. The cytoarchitecure of the bowel wall is altered with disruption of the muscularis mucosa, thickening of the muscularis propria, and deposition of collagen throughout. The cytokine TGF-beta appears critical in this process, acting to increase growth factor and extracellular matrix (ECM) production and dysregulate ECM turnover. Potential therapeutic interventions are likely to concentrate on modulating down-stream targets of TGF-beta.CONCLUSIONSGreater understanding of the biology of fibrostenosis is likely to yield significant advances in our ability to care for patients with stricturing CD. Potential dividends of this approach include identification of novel therapeutic targets and biomarkers useful for prognostication and therapeutic monitoring.
Author BURKE, John P
DOCHERTY, Neil G
RONAN O'CONNELL, P
O'KEANE, Conor
MULSOW, Jurgen J
WATSON, R. William G
Author_xml – sequence: 1
  givenname: John P
  surname: BURKE
  fullname: BURKE, John P
  organization: Department of Surgery, Mater Misericordiae University Hospital and UCD School of Medicine and Medical Science, United States
– sequence: 2
  givenname: Jurgen J
  surname: MULSOW
  fullname: MULSOW, Jurgen J
  organization: Department of Surgery, Mater Misericordiae University Hospital and UCD School of Medicine and Medical Science, United States
– sequence: 3
  givenname: Conor
  surname: O'KEANE
  fullname: O'KEANE, Conor
  organization: Department of Pathology, Mater Misericordiae University Hospital and UCD School of Medicine and Medical Science, United States
– sequence: 4
  givenname: Neil G
  surname: DOCHERTY
  fullname: DOCHERTY, Neil G
  organization: Conway Institute, University College Dublin, Dublin, Ireland
– sequence: 5
  givenname: R. William G
  surname: WATSON
  fullname: WATSON, R. William G
  organization: Conway Institute, University College Dublin, Dublin, Ireland
– sequence: 6
  givenname: P
  surname: RONAN O'CONNELL
  fullname: RONAN O'CONNELL, P
  organization: Department of Surgery, Mater Misericordiae University Hospital and UCD School of Medicine and Medical Science, United States
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18528893$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/17156147$$D View this record in MEDLINE/PubMed
BookMark eNpd0MtLwzAcB_AgE_fQf8ENRD215tG8jjKdCgMPeg9Zms6WLp3JCvO_N3VlA5NDDvn8HnzHYOAaZwGYIZiieB6qFFGOE4gzlGIIWQpRvOn-DIyOHwMwghDiRGIOh2AcQgUhopjTCzBEHFGGMj4C00W58s3aOhvKMCvdbO6bL3cfZk9lsDrYS3Be6DrYq_6dgI_F8-f8NVm-v7zNH5eJIZLuEolyXjBrmCWE58yQIqcGciZozkmGBYI0pzLTEVNsNeW6ICtOLTXICEEm4O7Qdeub79aGndqUwdi61s42bVBMQiyh7ODNP1g1rXdxM4W4IExmiHZKHJTxTQjeFmrry432PwpB1QWoKtXlpLqcVBeg-gtQ7WPpdT-gXW1sfirsE4vgtgc6GF0XXjtThpMTFAshSXTTg3N613p7BLpax4GcMfILd9eCbQ
CitedBy_id crossref_primary_10_1371_journal_pone_0052332
crossref_primary_10_1152_ajpgi_00244_2011
crossref_primary_10_3390_nu14020352
crossref_primary_10_1093_ecco_jcc_jjw055
crossref_primary_10_1016_j_jss_2009_09_051
crossref_primary_10_1016_j_pharmthera_2013_04_005
crossref_primary_10_1021_acs_langmuir_7b01504
crossref_primary_10_1093_ibd_izz329
crossref_primary_10_1152_ajpgi_00528_2010
crossref_primary_10_1007_s00261_011_9793_y
crossref_primary_10_1002_mnfr_200900543
crossref_primary_10_1097_MIB_0b013e3182813297
crossref_primary_10_1016_j_cyto_2012_11_021
crossref_primary_10_1053_j_semnuclmed_2016_12_005
crossref_primary_10_1586_17474124_2013_814931
crossref_primary_10_1016_j_matbio_2012_11_001
crossref_primary_10_1002_ibd_21539
crossref_primary_10_3389_fmicb_2021_694967
crossref_primary_10_1002_eji_201343524
crossref_primary_10_1016_j_dci_2020_103989
crossref_primary_10_2174_1381612825666190308100844
crossref_primary_10_3390_nu15010099
crossref_primary_10_1002_ibd_22991
crossref_primary_10_1111_j_1365_2982_2012_01986_x
crossref_primary_10_1111_j_1365_2362_2008_01955_x
crossref_primary_10_1016_j_matbio_2009_11_004
crossref_primary_10_3390_diagnostics12051236
crossref_primary_10_3389_fimmu_2017_01787
crossref_primary_10_1016_j_humpath_2014_05_016
crossref_primary_10_1002_ibd_21543
crossref_primary_10_1002_ibd_21648
crossref_primary_10_1038_sj_bjp_0707486
crossref_primary_10_1007_s00535_017_1350_1
crossref_primary_10_1007_s00394_018_1661_x
crossref_primary_10_1111_j_1365_2362_2008_02076_x
crossref_primary_10_1016_j_ajpath_2011_03_018
crossref_primary_10_1159_000513061
crossref_primary_10_1016_j_phrs_2020_104757
crossref_primary_10_1053_j_gastro_2019_08_033
crossref_primary_10_1111_1751_2980_12913
crossref_primary_10_1159_000528312
crossref_primary_10_1016_j_prp_2017_11_017
crossref_primary_10_1155_2019_8320250
crossref_primary_10_1080_17474124_2019_1673729
crossref_primary_10_1093_ibd_izaa321
crossref_primary_10_1016_j_dld_2019_09_019
crossref_primary_10_1016_j_jss_2012_01_048
crossref_primary_10_2353_ajpath_2010_100314
crossref_primary_10_1002_ibd_21647
crossref_primary_10_1053_j_gastro_2008_01_019
crossref_primary_10_1111_micc_12364
crossref_primary_10_1148_rg_2020190091
crossref_primary_10_1542_pir_30_12_486
crossref_primary_10_1007_s00595_023_02759_w
crossref_primary_10_1152_ajpgi_00351_2009
crossref_primary_10_1007_s10620_019_05969_w
crossref_primary_10_1042_CS20140048
crossref_primary_10_1093_ecco_jcc_jjad178
crossref_primary_10_1097_MIB_0000000000000542
crossref_primary_10_1016_j_trsl_2019_03_005
crossref_primary_10_1038_nrgastro_2009_45
crossref_primary_10_3390_ijms232012445
crossref_primary_10_1016_j_crohns_2008_10_002
crossref_primary_10_1016_j_jnutbio_2013_02_007
crossref_primary_10_1111_nyas_13426
crossref_primary_10_1038_labinvest_3700669
crossref_primary_10_1053_j_gastro_2018_11_029
crossref_primary_10_1097_01_MIB_0000438430_15553_90
crossref_primary_10_1152_ajpgi_90311_2008
crossref_primary_10_14309_ctg_0000000000000330
crossref_primary_10_1007_s10620_013_2813_8
crossref_primary_10_1038_s41385_019_0146_4
crossref_primary_10_1128_IAI_00096_10
crossref_primary_10_4132_jptm_2022_11_02
crossref_primary_10_1371_journal_pone_0209656
crossref_primary_10_1177_2050640616635957
crossref_primary_10_1007_s10620_020_06227_0
crossref_primary_10_1007_s11726_011_0458_8
crossref_primary_10_1007_s00464_008_0079_6
crossref_primary_10_1016_j_urology_2013_05_007
crossref_primary_10_3748_wjg_v24_i17_1859
crossref_primary_10_1038_mi_2011_18
crossref_primary_10_1111_apt_12051
crossref_primary_10_3389_fgene_2021_688447
crossref_primary_10_1136_gutjnl_2012_304353
crossref_primary_10_1097_MCG_0000000000000041
crossref_primary_10_1038_s41572_020_0156_2
crossref_primary_10_1016_j_tgie_2016_08_004
crossref_primary_10_3390_biomedicines10030570
crossref_primary_10_1002_ibd_21281
crossref_primary_10_1093_ecco_jcc_jjad164
crossref_primary_10_1371_journal_pone_0144630
crossref_primary_10_1016_j_crohns_2011_11_009
crossref_primary_10_1111_j_1365_2559_2010_03640_x
crossref_primary_10_1002_ibd_21843
crossref_primary_10_1097_MIB_0000000000000679
crossref_primary_10_1053_j_gastro_2007_12_043
crossref_primary_10_1002_ibd_21167
crossref_primary_10_1089_ars_2015_6611
crossref_primary_10_3390_jcm11164713
crossref_primary_10_1186_1755_1536_6_13
crossref_primary_10_3109_00365521_2014_968863
crossref_primary_10_1002_ibd_21153
crossref_primary_10_1186_s12876_017_0627_4
crossref_primary_10_1155_2015_964131
crossref_primary_10_1016_j_autrev_2017_02_013
crossref_primary_10_1038_nrgastro_2015_186
crossref_primary_10_1152_ajpgi_00059_2012
crossref_primary_10_1016_j_clnu_2011_07_001
crossref_primary_10_1016_j_crohns_2008_05_009
crossref_primary_10_1007_s00261_012_9853_y
crossref_primary_10_1097_MIB_0000000000000618
crossref_primary_10_1016_j_lfs_2019_01_059
crossref_primary_10_1089_neu_2017_5369
crossref_primary_10_1093_ecco_jcc_jjw101
crossref_primary_10_1016_S0140_6736_17_30317_3
crossref_primary_10_1038_ncomms2957
crossref_primary_10_1016_j_ajpath_2020_05_015
crossref_primary_10_1148_rg_2017160064
crossref_primary_10_1017_S0007114508009847
crossref_primary_10_1097_MD_0000000000000940
crossref_primary_10_1089_ars_2012_4530
crossref_primary_10_5217_ir_2019_09148
crossref_primary_10_1021_pr200807p
crossref_primary_10_1042_CS20150472
crossref_primary_10_1097_MOG_0b013e3282ff8b36
crossref_primary_10_1007_s10620_020_06161_1
crossref_primary_10_1016_j_biopha_2020_110317
crossref_primary_10_1007_s00535_010_0232_6
crossref_primary_10_1016_j_jss_2015_04_036
crossref_primary_10_1016_j_rvsc_2022_09_021
crossref_primary_10_3389_fphar_2020_00730
crossref_primary_10_3892_mmr_2015_3582
crossref_primary_10_1177_17562848241230896
crossref_primary_10_1007_s10350_008_9348_7
crossref_primary_10_1016_j_ebiom_2021_103452
crossref_primary_10_1093_ibd_izab251
crossref_primary_10_1016_j_bbadis_2013_10_012
crossref_primary_10_1093_ecco_jcc_jjz158
crossref_primary_10_3390_nu13030913
crossref_primary_10_1152_ajpgi_00400_2014
crossref_primary_10_1371_journal_pone_0100921
crossref_primary_10_1016_j_acthis_2023_152115
crossref_primary_10_1002_ibd_21243
crossref_primary_10_1016_j_crohns_2014_02_009
crossref_primary_10_1080_17474124_2020_1759417
crossref_primary_10_1097_MIB_0000000000000997
crossref_primary_10_1007_s00418_009_0580_6
crossref_primary_10_1152_ajpgi_00038_2012
crossref_primary_10_1002_ibd_20817
crossref_primary_10_22141_2308_2097_56_3_2022_505
crossref_primary_10_4049_jimmunol_1801308
crossref_primary_10_1097_MOG_0000000000000363
crossref_primary_10_3945_jn_110_121525
crossref_primary_10_3390_ph17030347
crossref_primary_10_1152_ajpgi_00083_2011
crossref_primary_10_1002_mnfr_201601085
crossref_primary_10_1016_j_cytogfr_2013_11_001
crossref_primary_10_1080_08923973_2020_1799388
crossref_primary_10_1016_j_rcl_2018_05_001
crossref_primary_10_1080_00365521_2016_1185146
crossref_primary_10_3390_diagnostics13132188
crossref_primary_10_2174_1381612825666191216154224
crossref_primary_10_1186_1479_5876_11_91
crossref_primary_10_3389_fimmu_2023_1163198
crossref_primary_10_1093_ecco_jcc_jjac017
crossref_primary_10_1016_j_tips_2016_10_014
crossref_primary_10_1016_j_crohns_2010_11_003
crossref_primary_10_1038_s41598_023_50461_1
crossref_primary_10_1002_ibd_20482
crossref_primary_10_1186_1756_0500_6_387
crossref_primary_10_3390_biom11010017
crossref_primary_10_1097_MIB_0000000000000043
crossref_primary_10_3390_biomedicines10040765
crossref_primary_10_1055_s_0044_1786376
crossref_primary_10_1016_j_ajpath_2011_07_042
crossref_primary_10_1016_j_phrs_2020_105243
crossref_primary_10_1093_ibd_izaa125
crossref_primary_10_1002_ibd_21335
crossref_primary_10_1007_s11726_012_0631_8
crossref_primary_10_1517_13543784_2016_1165204
crossref_primary_10_5217_ir_2015_13_1_19
crossref_primary_10_1016_j_tips_2008_10_007
crossref_primary_10_1093_ecco_jcc_jjz117
crossref_primary_10_3748_wjg_v22_i22_5154
crossref_primary_10_1159_000511075
crossref_primary_10_3748_wjg_v23_i3_437
crossref_primary_10_1007_s00384_013_1698_5
crossref_primary_10_1080_00365521_2019_1683224
crossref_primary_10_1097_MOG_0000000000000280
crossref_primary_10_2527_jas_2013_7106
crossref_primary_10_1002_ibd_21446
crossref_primary_10_1053_j_gastro_2012_12_001
crossref_primary_10_1016_j_humpath_2018_03_004
crossref_primary_10_1167_iovs_18_24813
Cites_doi 10.1016/0016-5085(88)90411-8
10.1136/gut.47.1.57
10.1097/00054725-200401000-00009
10.1016/j.cardiores.2004.03.010
10.1096/fj.02-0204fje
10.1097/01.mlg.0000150694.08259.80
10.1053/gast.2000.20229
10.3109/00365529509096316
10.1016/S0016-5107(87)71479-5
10.1016/S1357-2725(98)00046-6
10.1126/science.1103685
10.1136/gut.52.4.552
10.1097/00054725-200409000-00007
10.1046/j.1523-1755.2002.00462.x
10.1016/0016-5085(92)90087-F
10.1016/0005-2795(75)90106-3
10.1097/00054725-200402001-00003
10.1016/j.dld.2005.02.011
10.1016/0016-5085(95)90121-3
10.1136/gut.25.6.665
10.1053/j.gastro.2003.08.027
10.1152/ajpgi.00057.2002
10.1074/jbc.M505291200
10.1111/j.1365-2036.2006.02786.x
10.1016/S0016-5107(00)70366-X
10.1097/00054725-200309000-00001
10.1001/archsurg.134.5.471
10.1172/JCI1876
10.1046/j.1524-475X.1999.00477.x
10.1111/j.1572-0241.2001.03466.x
10.1016/0016-5085(85)90007-1
10.1093/molehr/5.10.950
10.1080/00365521.1976.12097167
10.1053/gast.2002.32413
10.1152/ajpgi.2000.279.6.G1307
10.1016/S0140-6736(02)07284-7
10.3748/wjg.v12.i8.1235
10.1172/JCI200112020
10.1155/2001/426968
10.1097/00001574-200403000-00006
10.1681/ASN.2005020202
10.1136/gut.29.5.588
10.1136/gut.2004.045294
10.1016/S0021-9258(17)44894-0
10.1152/ajpgi.00051.2005
10.1016/j.jaci.2005.03.036
10.1053/j.gastro.2004.01.063
10.1038/35079114
10.1074/jbc.M413102200
10.1016/0014-4800(81)90030-7
10.1159/000199850
10.1016/0016-5085(90)90613-6
10.1016/S0161-6420(99)00019-6
10.1097/00002281-200211000-00009
10.1016/S0016-5085(99)70549-4
10.1152/ajpcell.00048.2001
10.1055/s-2003-38145
10.1053/gast.2002.35393
10.1046/j.1365-2249.2000.01227.x
10.1006/clin.1998.4606
10.1096/fj.03-1273rev
10.1046/j.1365-2036.2003.01536.x
10.1007/s10350-004-6296-8
10.1007/s10350-004-6294-x
10.1016/S0016-5085(99)70125-3
10.1136/gut.49.6.777
10.1097/00054725-200207000-00002
10.1097/00000658-200204000-00008
10.4049/jimmunol.164.12.6174
10.1136/gut.2005.068429
10.1006/niox.2001.0421
10.1111/j.1572-0241.2006.00463.x
10.3109/00365527809181743
10.1517/14728222.5.4.519
10.1016/j.jamcollsurg.2004.02.028
10.1038/sj.bjp.0704173
10.1053/j.gastro.2005.01.010
10.1111/j.1572-0241.2000.01779.x
10.1016/S0016-5085(76)80196-5
10.1152/ajpgi.2000.279.4.G653
10.1002/jcp.10275
10.1152/ajpgi.00050.2003
10.1016/j.it.2003.10.007
10.1038/35079107
10.1097/00000658-200001000-00007
10.1097/00054725-200002000-00002
10.1097/01.sla.0000189606.58343.cd
10.1016/0092-8674(92)90115-S
10.1172/JCI200112821
10.1136/gut.51.3.405
10.1136/gut.2005.076604
10.1007/BF02234814
10.1053/j.gastro.2004.05.010
10.1167/iovs.02-0860
10.1002/bjs.4453
10.1159/000087130
10.1086/339432
10.4049/jimmunol.172.3.1862
10.1038/379821a0
10.1007/s10350-004-0692-4
10.1016/S0898-6568(02)00058-X
10.1111/j.1523-1755.2004.00710.x
10.1136/gut.47.1.63
10.1074/jbc.M210366200
10.1097/00002281-200111000-00010
10.1016/0016-5085(92)90314-O
10.1111/j.1572-0241.1999.01538.x
10.1111/j.1365-2036.2005.02526.x
10.1016/S1072-7515(01)00775-X
10.1002/bjs.5431
10.1016/S0140-6736(02)08590-2
10.1006/jmcc.2000.1215
10.1016/S0002-9440(10)63931-4
10.1681/ASN.2005030297
10.1007/BF02053938
10.1097/00000658-199901000-00009
10.1136/gut.50.1.65
ContentType Journal Article
Copyright 2007 INIST-CNRS
Copyright Nature Publishing Group Feb 2007
Copyright_xml – notice: 2007 INIST-CNRS
– notice: Copyright Nature Publishing Group Feb 2007
DBID IQODW
CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
BENPR
CCPQU
FYUFA
GHDGH
K9.
M0S
M1P
PQEST
PQQKQ
PQUKI
PRINS
7X8
8BM
DOI 10.1111/j.1572-0241.2006.01010.x
DatabaseName Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central
ProQuest One Community College
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
PML(ProQuest Medical Library)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
ComDisDome
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Central China
ProQuest Hospital Collection (Alumni)
ProQuest Central
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest Medical Library
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
ProQuest One Academic
ProQuest Medical Library (Alumni)
ProQuest Central (Alumni)
ComDisDome
MEDLINE - Academic
DatabaseTitleList MEDLINE
ProQuest One Academic Eastern Edition
ComDisDome
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: 7X7
  name: ProQuest_Health & Medical Collection
  url: https://search.proquest.com/healthcomplete
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
EISSN 1572-0241
EndPage 448
ExternalDocumentID 4032442541
10_1111_j_1572_0241_2006_01010_x
17156147
18528893
ajg200766
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID -
-Q-
08R
0R
123
1B1
23M
31
39C
3O-
3V.
4.4
4G.
53G
55
5RE
5VS
70F
7X7
88E
8FI
8FJ
8GM
AADWK
AAEDT
AALRI
AAMOA
AAQFI
AAQQT
AAQXK
AAXUO
AAYJO
AAYOK
AAZLF
ABAWZ
ABFLS
ABOCM
ABPTK
ABUWG
ACGFS
ACKTT
ACXQS
ADBBV
ADBIT
ADNKB
ADQMX
AEDAW
AENEX
AEXYK
AFBPY
AFFNX
AFKRA
AFSHS
AFUWQ
AHGBK
AHMBA
AHSBF
AHVBC
AJIOK
AJRNO
ALMA_UNASSIGNED_HOLDINGS
ALMTX
AMJPA
AMKUR
BBAFP
BENPR
BPHCQ
BVXVI
C45
CAG
COF
CS3
DIWNM
EBS
EE.
EJD
EMB
F5P
FDB
FDQFY
FEDTE
FGOYB
FYUFA
GJ
HVGLF
HZ
IHE
IKREB
IKYAY
IPNFZ
JSO
K
LH4
LW6
M1P
M41
NQ-
O9-
OPUJH
OVD
OVDNE
OVIDB
P0W
P2P
PQEST
PQQKQ
PQUKI
PROAC
PSQYO
Q-
R2-
RIG
RNTTT
ROL
RPZ
SEW
SJN
SNX
SSZ
SV3
TEORI
UDS
VH1
X7M
XPP
ZA5
ZGI
ZXP
ZZMQN
---
--K
.55
.GJ
0R~
1OC
31~
36B
6J9
AAGIX
AAHPQ
AAJCS
AAQKA
AASXQ
AAUGY
ABASU
ABDIG
ABLJU
ACGFO
ACILI
ACNWC
ACOAL
ADFRT
ADGGA
ADMUD
AEBDS
AEETU
AFDTB
AFEBI
AGAYW
AHOMT
AI.
AJAOE
AJNWD
AKULP
AMNEI
AOHHW
BYPQX
CCPQU
EEVPB
EMOBN
FCALG
GNXGY
GQDEL
HZ~
IQODW
N4W
ODMTH
RLZ
RNT
TSPGW
UKHRP
XIF
AAAAV
AAIQE
AASCR
ABJNI
ABVCZ
ACLDA
ACXJB
ADHPY
AFEXH
AHQNM
AINUH
AJZMW
AKRWK
ALIPV
CGR
CUY
CVF
ECM
EIF
ERAAH
HLJTE
HMCUK
NPM
AAYXX
ACRPL
CITATION
7XB
8FK
K9.
PRINS
7X8
8BM
ID FETCH-LOGICAL-c395t-91d7f6ec6e337d6c3fd5c07685d73428105d594a39552ea57af3b75e5c1c883
IEDL.DBID 7X7
ISSN 0002-9270
IngestDate Wed Dec 04 03:34:27 EST 2024
Tue Nov 19 06:11:49 EST 2024
Fri Dec 06 04:59:31 EST 2024
Tue Oct 15 23:42:40 EDT 2024
Sun Oct 22 16:09:05 EDT 2023
Thu Oct 07 19:37:16 EDT 2021
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords Crohn disease
Digestive diseases
Intestinal disease
Inflammatory disease
Language English
License CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c395t-91d7f6ec6e337d6c3fd5c07685d73428105d594a39552ea57af3b75e5c1c883
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
PMID 17156147
PQID 1783694158
PQPubID 2041977
PageCount 10
ParticipantIDs proquest_miscellaneous_69029098
proquest_journals_1783694158
crossref_primary_10_1111_j_1572_0241_2006_01010_x
pubmed_primary_17156147
pascalfrancis_primary_18528893
nature_primary_ajg200766
ProviderPackageCode RNTTT
AEDAW
AAZLF
-Q-
AADWK
AAYJO
AHGBK
70F
ADQMX
EE.
PublicationCentury 2000
PublicationDate 2007-02-01
PublicationDateYYYYMMDD 2007-02-01
PublicationDate_xml – month: 02
  year: 2007
  text: 2007-02-01
  day: 01
PublicationDecade 2000
PublicationPlace Oxford
PublicationPlace_xml – name: Oxford
– name: United States
– name: New York
PublicationTitle The American journal of gastroenterology
PublicationTitleAlternate Am J Gastroenterol
PublicationYear 2007
Publisher Blackwell Publishing
Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
Publisher_xml – name: Blackwell Publishing
– name: Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins
References Beddy, DJ, Watson, WR, Fitzpatrick, JM 2004; 199
Battaglia, E, Biancone, L, Resegotti, A 1999; 94
Liu, Z, Colpaert, S, D'Haens, GR 1999; 163
Ogura, Y, Bonen, DK, Inohara, N 2001; 411
Girardin, S, Hugot, J, Sansonetti, P 2003; 24
Cosnes, J, Nion-Larmurier, I, Beaugerie, L 2005; 54
Stratton, R, Shiwen, X, Martini, G 2001; 108
Stratton, R, Rajkumar, V, Ponticos, M 2002; 16
Motomura, Y, Khan, WI, El-Sharkawy, RT 2006; 55
Alvarez-Lobos, M, Arosregui, J, Sans, M 2005; 54
Casillas, S, Delaney, CP, Senagore, AJ 2004; 47
Ehrlich, HP, White, BS 1981; 34
Whelan, G, Farmer, RG, Fazio, VW 1985; 88
Shanahan, F 2002; 359
D'Haens, G, Baert, F, Van Assche, G 2005; 54
Cosnes, J, Cattan, S, Blain, A 2002; 8
Leask, A, Abraham, DJ 2004; 18
Marteau, P, Lemann, M, Seksik, P 2006; 55
Hellers, G, Cortot, A, Jewell, D 1999; 116
Eckmann, L 2004; 20
Louis, E, Michel, V, Hugot, JP 2003; 52
Farrokhyar, F, Swarbrick, ET, Grace, RH 2001; 96
Gao, Q, Meijer, MJ, Kubben, FJ 2005; 37
Rutgeerts, P, Geboes, K, Vantrappen, G 1984; 25
Stallmach, A, Schuppan, D, Riese, HH 1992; 102
Lichtenstein, GR, Olson, A, Travers, S 2006; 101
Hugot, JP, Chamaillard, M, Zouali, H 2001; 411
McKaig, BC, Hughes, K, Tighe, PJ 2002; 282
Monteleone, G, Kumberova, A, Croft, N 2001; 108
Hanauer, SB, Korelitz, BI, Rutgeerts, P 2004; 127
Brannigan, AE, Watson, RW, Beddy, D 2002; 235
Hayashi, N, Kakimuma, T, Soma, Y 2002; 49
Rutgeerts, P, Geboes, K, Vantrappen, G 1990; 99
Louis, E, Collard, A, Oger, A 2001; 49
Kernochan, LE, Tran, BN, Tangkijvanich, P 2002; 50
Farmer, RG, Hawk, WA, Turnbull, RB 1976; 71
Ahmad, T, Armuzzi, A, Bunce, M 2002; 122
Bergman, L, Krause, U 1976; 11
Hampe, J, Grebe, J, Nikolaus, S 2002; 359
Cosnes, J, Seksik, P, Nion-Larmurier, I 2006; 12
Sans, M, Tassies, D, Pellise, M 2003; 17
Vallance, BA, Gunawan, MI, Hewlett, B 2005; 289
McKaig, BC, McWilliams, D, Watson, SA 2003; 162
Eberlein, M, Heusinger-Ribeiro, J, Goppelt-Struebe, M 2001; 133
Dietz, DW, Laureti, S, Strong, SA 2001; 192
MacNaul, KL, Chartrain, N, Lark, M 1990; 265
Wenckert, A, Kristensen, M, Eklund, AE 1978; 13
Bamba, S, Andoh, A, Yasui, H 2003; 285
Greenstein, AJ, Lachman, P, Sachar, DB 1988; 29
Cohen, RD, Larson, LR, Roth, JM 2000; 95
Sappino, AP, Schurch, W, Gabbiani, G 1990; 63
Fedorak, RN, Gangl, A, Elson, CO 2000; 119
Yamamoto, T, Eckes, B, Mauch, C 2000; 164
Fazio, VW, Tjandra, JJ, Lavery, IC 1993; 36
Theiss, AL, Simmons, JG, Jobin, C 2005; 280
Ma, C, Chegini, N 1999; 5
Zeisberg, M, Shah, A, Kalluri, R 2005; 280
di Mola, FF, Friess, H, Scheuren, A 1999; 229
Poritz, LS, Rowe, WA, Koltun, WA 2002; 45
Maeda, S, Hsu, L, Liu, H 2005; 307
Kaufman, J, Sime, PJ, Phipps, RP 2004; 172
Prantera, C, Scribano, ML, Falasco, G 2002; 51
Matsuhashi, N, Nakajima, A, Suzuki, A 2000; 51
Mulsow, JJW, Watson, RWG, Fitzpatrick, JM 2005; 242
Abreu, MT, Taylor, KD, Lin, YC 2002; 123
Rutgeerts, P, Hiele, M, Geboes, K 1995; 108
Heusinger-Ribeiro, J, Fischer, B, Goppelt-Struebe, M 2004; 66
Van Assche, G, Geboes, K, Rutgeerts, P 2004; 10
Pontrelli, P, Ursi, M, Ranieri, E 2006; 17
Dammeier, J, Brauchle, M, Falk, W 1998; 30
Ferrini, MG, Vernet, D, Magee, TR 2002; 6
Silverstein, MD, Loftus, EV, Sandborn, WJ 1999; 117
Brant, S, Picco, M, Achkar, J 2003; 9
Kasran, A, Boon, L, Wortel, CH 2005; 22
Loftus, EV 2004; 126
Beddy, D, Watson, RW, Fitzpatrick, JM 2004; 91
Stawowy, P, Margeta, C, Kallisch, H 2004; 63
Ehrlich, HP 1988
Matthes, H, Herbst, H, Schuppan, D 1992; 102
Brooker, J, Beckett, C, Saunders, B 2003; 35
Maric, I, Poljak, L, Zoricic, S 2003; 196
Lawrance, IC, Wu, F, Leite, AZ 2003; 125
Bailey, AJ, Bazin, S, Sims, TJ 1975; 405
Ma, C, Tarnuzzer, RW, Chegini, N 1999; 7
Rutgeerts, P, Van Assche, G, Vermeire, S 2005; 128
Freeman, HJ 2001; 15
Pucilowska, JB, Williams, KL, Lund, PK 2000; 279
Ferguson, B, Gray, S, Thibeault, S 2005; 115
Smits, HH, Engering, A, Van der Kleij, D 2005; 115
Keil, A, Blom, IE, Goldschmeding, R 2002; 62
Crean, JK, Lappin, D, Godson, C 2001; 5
Majmudar, PA, Forstot, SL, Dennis, RF 2000; 107
Graham, MF, Diegelmann, RF, Elson, CO 1988; 94
Gasche, C, Scholmerich, J, Brynskov, J 2000; 6
Mu, W, Ouyang, X, Agarwal, A 2005; 16
Simmons, J, Pucilowska, J, Keku, T 2002; 283
Von Lampe, B, Barthel, B, Coupland, SE 2000; 47
Regan, MC, Flavin, BM, Fitzpatrick, JM 2000; 231
Rutgeerts, P, Van Assche, G, Vermeire, S 2006; 23
Denton, CP, Abraham, DJ 2001; 13
Beddy, D, Mulsow, J, Watson, RW 2006; 93
Bitzer, M, von Gersdorff, G, Liang, D 2000; 14
Louis, E, Ribbens, C, Godon, A 2000; 120
Lesage, S, Zouali, H, Cezard, JP 2002; 70
Hynes, RO 1992; 69
Casillas, S, Delaney, CP 2005; 22
Munkholm, P, Langholz, E, Davidsen, M 1995; 30
Pucilowska, JB, McNaughton, KK, Mohapatra, NK 2000; 279
Blalock, TD, Duncan, MR, Varela, JC 2003; 44
Chen, MM, Lam, A, Abraham, JA 2000; 32
Lutz, M, Knaus, P 2002; 14
Jobson, TM, Billington, CK, Hall, IP 1998; 101
Wengrower, D, Zannineli, G, Pappo, O 2004; 10
Leask, A, Holmes, A, Black, CM 2003; 278
Hugot, J, Laurent-Puig, P, Gower-Rousseau, C 1996; 379
Adawi, A, Zhang, Y, Baggs, R 1998; 89
Ewe, K, Herfarth, C, Malchow, H 1989; 42
Munoz-Juarez, M, Yamamoto, T, Wolff, BG 2001; 44
Ihn, H 2002; 14
Hugot, JP 2004; 10
Dietz, DW, Fazio, VW, Laureti, S 2002; 45
Heuschkel, RB, MacDonald, TT, Monteleone, G 2000; 47
Bedogni, G, Ricci, E, Pedrazzoli, C 1987; 33
Pandya, S, Murray, JJ, Coller, JA 1999; 134
b94_320
Jobson TM (b53_279) 1998; 101
b84_310
b28_254
b71_297
b80_306
b16_242
b119_345
b51_277
b58_284
b120_346
b105_331
Hayashi N (b59_285) 2002; 49
b48_274
b61_287
b41_267
b26_252
b79_305
b110_336
b6_232
b36_262
b100_326
Rutgeerts P (b7_233) 1984; 25
b68_294
b117_343
Bergman L (b107_333) 1976; 11
b32_258
b34_260
b101_327
b10_236
b56_282
b114_340
b77_303
b88_314
D'Haens G (b82_308) 2005; 54
Ferguson B (b111_337) 2005; 115
b99_325
b63_289
b52_278
Wenckert A (b108_334) 1978; 13
b123_349
b75_301
Whelan G (b9_235) 1985; 88
b86_312
b90_316
Alvarez-Lobos M (b33_259) 2005; 54
McKaig BC (b46_272) 2002; 282
b103_329
b97_323
b2_228
Pucilowska JB (b45_271) 2000; 279
b54_280
Graham MF (b4_230) 1988; 94
b65_291
b23_249
Stallmach A (b37_263) 1992; 102
b12_238
b70_296
b81_307
Ehrlich HP (b39_265) 1988
b95_321
Munkholm P (b19_245) 1995; 30
b91_317
b49_275
b60_286
Ewe K (b109_335) 1989; 42
Freeman HJ (b14_240) 2001; 15
Gasche C (b15_241) 2000; 6
b27_253
b116_342
b69_295
Liu Z (b87_313) 1999; 163
b47_273
b62_288
Farmer RG (b18_244) 1976; 71
b30_256
Stratton R (b118_344) 2002; 16
McKaig BC (b76_302) 2003; 162
b121_347
b35_261
b57_283
b5_231
Simmons J (b50_276) 2002; 283
Bedogni G (b92_318) 1987; 33
Cosnes J (b21_247) 2006; 12
b83_309
Greenstein AJ (b17_243) 1988; 29
b93_319
b106_332
b40_266
b25_251
Sappino AP (b43_269) 1990; 63
Bitzer M (b67_293) 2000; 14
b66_292
b55_281
b122_348
b78_304
b11_237
MacNaul KL (b73_299) 1990; 265
b24_250
b20_246
b104_330
b102_328
b113_339
Matthes H (b38_264) 1992; 102
b115_341
b31_257
b1_227
b42_268
b98_324
Yamamoto T (b72_298) 2000; 164
b13_239
Bamba S (b112_338) 2003; 285
Kaufman J (b89_315) 2004; 172
b74_300
b22_248
b29_255
b96_322
Rutgeerts P (b8_234) 1990; 99
Pucilowska JB (b44_270) 2000; 279
b64_290
b85_311
b3_229
b124_350
References_xml – volume: 108
  start-page: 601
  year: 2001
  end-page: 609
  article-title: Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease
  publication-title: J Clin Invest
  contributor:
    fullname: Croft, N
– volume: 63
  start-page: 144
  year: 1990
  end-page: 161
  article-title: Differentiation repertoire of fibroblastic cells: Expression of cytoskeletal proteins as marker of phenotypic modulations
  publication-title: Lab Invest
  contributor:
    fullname: Gabbiani, G
– volume: 42
  start-page: 224
  year: 1989
  end-page: 232
  article-title: Postoperative recurrence of Crohn's disease in relation to radicality of operation and sulfasalazine prophylaxis: A multicenter trial
  publication-title: Digestion
  contributor:
    fullname: Malchow, H
– volume: 12
  start-page: 1235
  year: 2006
  end-page: 1242
  article-title: Prior appendectomy and the phenotype and course of Crohn's disease
  publication-title: World J Gastroenterol
  contributor:
    fullname: Nion-Larmurier, I
– volume: 47
  start-page: 63
  year: 2000
  end-page: 73
  article-title: Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
  publication-title: Gut
  contributor:
    fullname: Coupland, SE
– volume: 47
  start-page: 1680
  year: 2004
  end-page: 1685
  article-title: Does conversion of a laparoscopic colectomy adversely affect patient outcome?
  publication-title: Dis Colon Rectum
  contributor:
    fullname: Senagore, AJ
– volume: 107
  start-page: 89
  year: 2000
  end-page: 94
  article-title: Topical mitomycin-C for subepithelial fibrosis after refractive corneal surgery
  publication-title: Ophthalmology
  contributor:
    fullname: Dennis, RF
– volume: 127
  start-page: 723
  year: 2004
  end-page: 729
  article-title: Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: A 2-year trial
  publication-title: Gastroenterology
  contributor:
    fullname: Rutgeerts, P
– volume: 108
  start-page: 241
  year: 2001
  end-page: 250
  article-title: Iloprost suppresses connective tissue growth factor production in fibroblasts and in the skin of scleroderma patients
  publication-title: J Clin Invest
  contributor:
    fullname: Martini, G
– volume: 119
  start-page: 1473
  year: 2000
  end-page: 1482
  article-title: Recombinant human interleukin 10 in the treatment of patients with mild to moderately active Crohn's disease. The Interleukin 10 Inflammatory Bowel Disease Cooperative Study Group
  publication-title: Gastroenterology
  contributor:
    fullname: Elson, CO
– volume: 196
  start-page: 258
  year: 2003
  end-page: 264
  article-title: Bone morphogenetic protein-7 reduces the severity of colon tissue damage and accelerates the healing of inflammatory bowel disease in rats
  publication-title: J Cell Physiol
  contributor:
    fullname: Zoricic, S
– volume: 66
  start-page: 187
  year: 2004
  end-page: 195
  article-title: Differential effects of simvastatin on mesangial cells
  publication-title: Kidney Int
  contributor:
    fullname: Goppelt-Struebe, M
– volume: 20
  start-page: 82
  year: 2004
  end-page: 88
  article-title: Innate immunity and mucosal bacterial interactions in the intestine
  publication-title: Curr Opin Gastroenterol
  contributor:
    fullname: Eckmann, L
– volume: 91
  start-page: 72
  year: 2004
  end-page: 77
  article-title: Increased vascular endothelial growth factor production in fibroblasts isolated from strictures in patients with Crohn's disease
  publication-title: Br J Surg
  contributor:
    fullname: Fitzpatrick, JM
– volume: 49
  start-page: 133
  year: 2002
  end-page: 135
  article-title: Connective tissue growth factor is directly related to liver fibrosis
  publication-title: Hepatogastroenterology
  contributor:
    fullname: Soma, Y
– volume: 405
  start-page: 412
  year: 1975
  end-page: 421
  article-title: Characterization of the collagen of human hypertrophic and normal scars
  publication-title: Biochim Biophys Acta
  contributor:
    fullname: Sims, TJ
– volume: 5
  start-page: 950
  year: 1999
  end-page: 954
  article-title: Regulation of matrix metalloproteinases (MMPs) and their tissue inhibitors in human myometrial smooth muscle cells by TGF-beta1
  publication-title: Mol Hum Reprod
  contributor:
    fullname: Chegini, N
– volume: 34
  start-page: 1
  year: 1981
  end-page: 8
  article-title: The identification of alpha A and alpha B collagen chains in hypertrophic scar
  publication-title: Exp Mol Pathol
  contributor:
    fullname: White, BS
– volume: 69
  start-page: 11
  year: 1992
  end-page: 25
  article-title: Integrins: Versatility, modulation, and signaling in cell adhesion
  publication-title: Cell
  contributor:
    fullname: Hynes, RO
– volume: 50
  start-page: 65
  year: 2002
  end-page: 70
  article-title: Endothelin-1 stimulates human colonic myofibroblast contraction and migration
  publication-title: Gut
  contributor:
    fullname: Tangkijvanich, P
– volume: 411
  start-page: 603
  year: 2001
  end-page: 606
  article-title: A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
  publication-title: Nature
  contributor:
    fullname: Inohara, N
– volume: 52
  start-page: 552
  year: 2003
  end-page: 557
  article-title: Early development of stricturing or penetrating pattern in Crohn's disease is influenced by disease location, number of flares, and smoking but not by NOD2 CARD15 genotype
  publication-title: Gut
  contributor:
    fullname: Hugot, JP
– volume: 307
  start-page: 734
  year: 2005
  end-page: 738
  article-title: Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
  publication-title: Science
  contributor:
    fullname: Liu, H
– volume: 8
  start-page: 244
  year: 2002
  end-page: 250
  article-title: Long-term evolution of disease behavior of Crohn's disease
  publication-title: Inflamm Bowel Dis
  contributor:
    fullname: Blain, A
– volume: 62
  start-page: 401
  year: 2002
  end-page: 411
  article-title: Nitric oxide down-regulates connective tissue growth factor in rat mesangial cells
  publication-title: Kidney Int
  contributor:
    fullname: Goldschmeding, R
– volume: 101
  start-page: 1030
  year: 2006
  end-page: 1038
  article-title: Factors associated with the development of intestinal strictures or obstructions in patients with Crohn's disease
  publication-title: Am J Gastroenterol
  contributor:
    fullname: Travers, S
– volume: 24
  start-page: 652
  year: 2003
  end-page: 658
  article-title: Lessons from Nod2 studies: Towards a link between Crohn's disease and bacterial sensing
  publication-title: Trends Immunol
  contributor:
    fullname: Sansonetti, P
– volume: 411
  start-page: 599
  year: 2001
  end-page: 603
  article-title: Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
  publication-title: Nature
  contributor:
    fullname: Zouali, H
– volume: 22
  start-page: 111
  year: 2005
  end-page: 122
  article-title: Safety and tolerability of antagonist anti-human CD40 Mab ch5D12 in patients with moderate to severe Crohn's disease
  publication-title: Aliment Pharmacol Ther
  contributor:
    fullname: Wortel, CH
– volume: 115
  start-page: 1260
  year: 2005
  end-page: 1267
  article-title: Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin
  publication-title: J Allergy Clin Immunol
  contributor:
    fullname: Van der Kleij, D
– volume: 44
  start-page: 20
  year: 2001
  end-page: 25
  article-title: Wide-lumen stapled anastomosis vs. conventional end-to-end anastomosis in the treatment of Crohn's disease
  publication-title: Dis Colon Rectum
  contributor:
    fullname: Wolff, BG
– volume: 63
  start-page: 87
  year: 2004
  end-page: 97
  article-title: Regulation of matrix metalloproteinase MT1-MMP MMP-2 in cardiac fibroblasts by TGF-beta1 involves furin-convertase
  publication-title: Cardiovasc Res
  contributor:
    fullname: Kallisch, H
– volume: 88
  start-page: 1826
  year: 1985
  end-page: 1833
  article-title: Recurrence after surgery in Crohn's disease. Relationship to location of disease (clinical pattern) and surgical indication
  publication-title: Gastroenterology
  contributor:
    fullname: Fazio, VW
– volume: 120
  start-page: 241
  year: 2000
  end-page: 246
  article-title: Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease
  publication-title: Clin Exp Immunol
  contributor:
    fullname: Godon, A
– start-page: 243
  year: 1988
  end-page: 258
  article-title: The role of connective tissue matrix in wound healing
  publication-title: Growth factors and other aspects of wound healing: Biological and clinical implications
  contributor:
    fullname: Ehrlich, HP
– volume: 30
  start-page: 699
  year: 1995
  end-page: 706
  article-title: Disease activity courses in a regional cohort of Crohn's disease patients
  publication-title: Scand J Gastroenterol
  contributor:
    fullname: Davidsen, M
– volume: 54
  start-page: A17
  year: 2005
  article-title: Better outcome with potent top-down induction therapy in recent onset Crohn's disease
  publication-title: Gut
  contributor:
    fullname: Van Assche, G
– volume: 101
  start-page: 2650
  year: 1998
  end-page: 2657
  article-title: Regulation of proliferation of human colonic subepithelial myofibroblasts by mediators important in intestinal inflammation
  publication-title: J Clin Invest
  contributor:
    fullname: Hall, IP
– volume: 33
  start-page: 21
  year: 1987
  end-page: 24
  article-title: Endoscopic dilation of anastomotic colonic stenosis by different techniques: an alternative to surgery?
  publication-title: Gastrointest Endosc
  contributor:
    fullname: Pedrazzoli, C
– volume: 29
  start-page: 588
  year: 1988
  end-page: 592
  article-title: Perforating and non-perforating indications for repeated operations in Crohn's disease: Evidence for two clinical forms
  publication-title: Gut
  contributor:
    fullname: Sachar, DB
– volume: 51
  start-page: 405
  year: 2002
  end-page: 409
  article-title: Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn's disease: A randomised controlled trial with Lactobacillus GG
  publication-title: Gut
  contributor:
    fullname: Falasco, G
– volume: 71
  start-page: 245
  year: 1976
  end-page: 250
  article-title: Indications for surgery in Crohn's disease: Analysis of 500 cases
  publication-title: Gastroenterology
  contributor:
    fullname: Turnbull, RB
– volume: 11
  start-page: 651
  year: 1976
  end-page: 656
  article-title: Postoperative treatment with corticosteroids and salazosulphapyridine (Salazopyrin) after radical resection for Crohn's disease
  publication-title: Scand J Gastroenterol
  contributor:
    fullname: Krause, U
– volume: 102
  start-page: 431
  year: 1992
  end-page: 442
  article-title: Cellular localization of procollagen gene transcripts in inflammatory bowel diseases
  publication-title: Gastroenterology
  contributor:
    fullname: Schuppan, D
– volume: 32
  start-page: 1805
  year: 2000
  end-page: 1819
  article-title: CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: A potential role in heart fibrosis
  publication-title: J Mol Cell Cardiol
  contributor:
    fullname: Abraham, JA
– volume: 55
  start-page: 662
  year: 2006
  end-page: 670
  article-title: Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1
  publication-title: Gut
  contributor:
    fullname: El-Sharkawy, RT
– volume: 93
  start-page: 1290
  year: 2006
  end-page: xx
  article-title: Expression and regulation of connective tissue growth factor by transforming growth factor beta and tumour necrosis factor alpha in fibroblasts isolated from strictures in patients with Crohn's disease
  publication-title: Br J Surg
  contributor:
    fullname: Watson, RW
– volume: 242
  start-page: 880
  year: 2005
  end-page: 887
  article-title: Transforming growth factor-beta promotes pro-fibrotic behavior by serosal fibroblasts via PKC and ERK1 2 mitogen activated protein kinase cell signaling
  publication-title: Ann Surg
  contributor:
    fullname: Fitzpatrick, JM
– volume: 14
  start-page: 977
  year: 2002
  end-page: 988
  article-title: Integration of the TGF-beta pathway into the cellular signalling network
  publication-title: Cell Signal
  contributor:
    fullname: Knaus, P
– volume: 289
  start-page: G116
  year: 2005
  end-page: G128
  article-title: TGF-beta1 gene transfer to the mouse colon leads to intestinal fibrosis
  publication-title: Am J Physiol Gastrointest Liver Physiol
  contributor:
    fullname: Hewlett, B
– volume: 17
  start-page: 627
  year: 2006
  end-page: 636
  article-title: CD40L proinflammatory and profibrotic effects on proximal tubular epithelial cells: role of NF-kappaB and lyn
  publication-title: J Am Soc Nephrol
  contributor:
    fullname: Ranieri, E
– volume: 10
  start-page: 55
  year: 2004
  end-page: 60
  article-title: Medical therapy for Crohn's disease strictures
  publication-title: Inflamm Bowel Dis
  contributor:
    fullname: Rutgeerts, P
– volume: 7
  start-page: 477
  year: 1999
  end-page: 485
  article-title: Expression of matrix metalloproteinases and tissue inhibitor of matrix metalloproteinases in mesothelial cells and their regulation by transforming growth factor-beta1
  publication-title: Wound Repair Regen
  contributor:
    fullname: Chegini, N
– volume: 108
  start-page: 1617
  year: 1995
  end-page: 1621
  article-title: Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection
  publication-title: Gastroenterology
  contributor:
    fullname: Geboes, K
– volume: 17
  start-page: 1039
  year: 2003
  end-page: 1047
  article-title: The 4G 4G genotype of the 4G 5G polymorphism of the type-1 plasminogen activator inhibitor (PAI-1) gene is a determinant of penetrating behaviour in patients with Crohn's disease
  publication-title: Aliment Pharmacol Ther
  contributor:
    fullname: Pellise, M
– volume: 116
  start-page: 294
  year: 1999
  end-page: 300
  article-title: Oral budesonide for prevention of postsurgical recurrence in Crohn's disease. The IOIBD Budesonide Study Group
  publication-title: Gastroenterology
  contributor:
    fullname: Jewell, D
– volume: 16
  start-page: 3651
  year: 2005
  end-page: 3660
  article-title: IL-10 suppresses chemokines, inflammation, and fibrosis in a model of chronic renal disease
  publication-title: J Am Soc Nephrol
  contributor:
    fullname: Agarwal, A
– volume: 51
  start-page: 343
  year: 2000
  end-page: 345
  article-title: Long-term outcome of non-surgical strictureplasty using metallic stents for intestinal strictures in Crohn's disease
  publication-title: Gastrointest Endosc
  contributor:
    fullname: Suzuki, A
– volume: 13
  start-page: 161
  year: 1978
  end-page: 167
  article-title: The long-term prophylactic effect of salazosulphapyridine (Salazopyrin) in primarily resected patients with Crohn's disease. A controlled double-blind trial
  publication-title: Scand J Gastroenterol
  contributor:
    fullname: Eklund, AE
– volume: 16
  start-page: 1949
  year: 2002
  end-page: 1951
  article-title: Prostacyclin derivatives prevent the fibrotic response to TGF-beta by inhibiting the Ras MEK ERK pathway
  publication-title: FASEB J
  contributor:
    fullname: Ponticos, M
– volume: 359
  start-page: 1661
  year: 2002
  end-page: 1665
  article-title: Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: A cohort study
  publication-title: Lancet
  contributor:
    fullname: Nikolaus, S
– volume: 133
  start-page: 1172
  year: 2001
  end-page: 1180
  article-title: Rho-dependent inhibition of the induction of connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins)
  publication-title: Br J Pharmacol
  contributor:
    fullname: Goppelt-Struebe, M
– volume: 229
  start-page: 67
  year: 1999
  end-page: 75
  article-title: Transforming growth factor-betas and their signaling receptors are coexpressed in Crohn's disease
  publication-title: Ann Surg
  contributor:
    fullname: Scheuren, A
– volume: 122
  start-page: 854
  year: 2002
  end-page: 866
  article-title: The molecular classification of the clinical manifestations of Crohn's disease
  publication-title: Gastroenterology
  contributor:
    fullname: Bunce, M
– volume: 235
  start-page: 507
  year: 2002
  end-page: 511
  article-title: Increased adhesion molecule expression in serosal fibroblasts isolated from patients with inflammatory bowel disease is secondary to inflammation
  publication-title: Ann Surg
  contributor:
    fullname: Beddy, D
– volume: 280
  start-page: 8094
  year: 2005
  end-page: 8100
  article-title: Bone morphogenic protein-7 induces mesenchymal to epithelial transition in adult renal fibroblasts and facilitates regeneration of injured kidney
  publication-title: J Biol Chem
  contributor:
    fullname: Kalluri, R
– volume: 55
  start-page: 842
  year: 2006
  end-page: 847
  article-title: Ineffectiveness of LA1 for prophylaxis of postoperative recurrence in Crohn's disease: A randomised, double blind, placebo controlled GETAID trial
  publication-title: Gut
  contributor:
    fullname: Seksik, P
– volume: 13
  start-page: 505
  year: 2001
  end-page: 511
  article-title: Transforming growth factor-beta and connective tissue growth factor: Key cytokines in scleroderma pathogenesis
  publication-title: Curr Opin Rheumatol
  contributor:
    fullname: Abraham, DJ
– volume: 279
  start-page: G653
  year: 2000
  end-page: G659
  article-title: Fibrogenesis. IV. Fibrosis and inflammatory bowel disease: Cellular mediators and animal models
  publication-title: Am J Physiol Gastrointest Liver Physiol
  contributor:
    fullname: Lund, PK
– volume: 162
  start-page: 1355
  year: 2003
  end-page: 1360
  article-title: Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease
  publication-title: Am J Pathol
  contributor:
    fullname: Watson, SA
– volume: 99
  start-page: 956
  year: 1990
  end-page: 963
  article-title: Predictability of the postoperative course of Crohn's disease
  publication-title: Gastroenterology
  contributor:
    fullname: Vantrappen, G
– volume: 280
  start-page: 36099
  year: 2005
  end-page: 36109
  article-title: Tumor necrosis factor (TNF) alpha increases collagen accumulation and proliferation in intestinal myofibroblasts via TNF receptor 2
  publication-title: J Biol Chem
  contributor:
    fullname: Jobin, C
– volume: 89
  start-page: 222
  year: 1998
  end-page: 230
  article-title: Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis
  publication-title: Clin Immunol Immunopathol
  contributor:
    fullname: Baggs, R
– volume: 22
  start-page: 135
  year: 2005
  end-page: 142
  article-title: Laparoscopic surgery for inflammatory bowel disease
  publication-title: Dig Surg
  contributor:
    fullname: Delaney, CP
– volume: 126
  start-page: 1504
  year: 2004
  end-page: 1517
  article-title: Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences
  publication-title: Gastroenterology
  contributor:
    fullname: Loftus, EV
– volume: 94
  start-page: 257
  year: 1988
  end-page: 265
  article-title: Collagen content and types in the intestinal strictures of Crohn's disease
  publication-title: Gastroenterology
  contributor:
    fullname: Elson, CO
– volume: 265
  start-page: 17238
  year: 1990
  end-page: 17245
  article-title: Discoordinate expression of stromelysin, collagenase, and tissue inhibitor of metalloproteinases-1 in rheumatoid human synovial fibroblasts. Synergistic effects of interleukin-1 and tumor necrosis factor-alpha on stromelysin expression
  publication-title: J Biol Chem
  contributor:
    fullname: Lark, M
– volume: 102
  start-page: 1920
  year: 1992
  end-page: 1929
  article-title: Increased collagen type III synthesis by fibroblasts isolated from strictures of patients with Crohn's disease
  publication-title: Gastroenterology
  contributor:
    fullname: Riese, HH
– volume: 45
  start-page: 764
  year: 2002
  end-page: 770
  article-title: Strictureplasty in diffuse Crohn's jejunoileitis: Safe and durable
  publication-title: Dis Colon Rectum
  contributor:
    fullname: Laureti, S
– volume: 192
  start-page: 330
  year: 2001
  end-page: 337
  article-title: Safety and longterm efficacy of strictureplasty in 314 patients with obstructing small bowel Crohn's disease
  publication-title: J Am Coll Surg
  contributor:
    fullname: Strong, SA
– volume: 128
  start-page: 856
  year: 2005
  end-page: 861
  article-title: Ornidazole for prophylaxis of postoperative Crohn's disease recurrence: A randomized, double-blind, placebo-controlled trial
  publication-title: Gastroenterology
  contributor:
    fullname: Vermeire, S
– volume: 25
  start-page: 665
  year: 1984
  end-page: 672
  article-title: Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery
  publication-title: Gut
  contributor:
    fullname: Vantrappen, G
– volume: 44
  start-page: 1879
  year: 2003
  end-page: 1887
  article-title: Connective tissue growth factor expression and action in human corneal fibroblast cultures and rat corneas after photorefractive keratectomy
  publication-title: Invest Ophthalmol Vis Sci
  contributor:
    fullname: Varela, JC
– volume: 54
  start-page: A78
  year: 2005
  article-title: Combined type-1 plasminogen activator inhibitor (PAI-1) and NOD2 CARD15 genotyping predicts Crohn's disease behaviour
  publication-title: Gut
  contributor:
    fullname: Sans, M
– volume: 117
  start-page: 49
  year: 1999
  end-page: 57
  article-title: Clinical course and costs of care for Crohn's disease: Markov model analysis of a population-based cohort
  publication-title: Gastroenterology
  contributor:
    fullname: Sandborn, WJ
– volume: 199
  start-page: 234
  year: 2004
  end-page: 242
  article-title: Critical involvement of stress-activated mitogen-activated protein kinases in the regulation of intracellular adhesion molecule-1 in serosal fibroblasts isolated from patients with Crohn's disease
  publication-title: J Am Coll Surg
  contributor:
    fullname: Fitzpatrick, JM
– volume: 47
  start-page: 57
  year: 2000
  end-page: 62
  article-title: Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease
  publication-title: Gut
  contributor:
    fullname: Monteleone, G
– volume: 95
  start-page: 524
  year: 2000
  end-page: 530
  article-title: The cost of hospitalization in Crohn's disease
  publication-title: Am J Gastroenterol
  contributor:
    fullname: Roth, JM
– volume: 6
  start-page: 8
  year: 2000
  end-page: 15
  article-title: A simple classification of Crohn's disease: Report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998
  publication-title: Inflamm Bowel Dis
  contributor:
    fullname: Brynskov, J
– volume: 134
  start-page: 471
  year: 1999
  end-page: 475
  article-title: Laparoscopic colectomy: Indications for conversion to laparotomy
  publication-title: Arch Surg
  contributor:
    fullname: Coller, JA
– volume: 283
  start-page: G809
  year: 2002
  end-page: G818
  article-title: IGF-I and TGF-beta1 have distinct effects on phenotype and proliferation of intestinal fibroblasts
  publication-title: Am J Physiol Gastrointest Liver Physiol
  contributor:
    fullname: Keku, T
– volume: 54
  start-page: 237
  year: 2005
  end-page: 241
  article-title: Impact of the increasing use of immunosuppressants in Crohn's disease on the need for intestinal surgery
  publication-title: Gut
  contributor:
    fullname: Beaugerie, L
– volume: 278
  start-page: 13008
  year: 2003
  end-page: 13015
  article-title: Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts
  publication-title: J Biol Chem
  contributor:
    fullname: Black, CM
– volume: 14
  start-page: 681
  year: 2002
  end-page: 685
  article-title: Pathogenesis of fibrosis: Role of TGF-beta and CTGF
  publication-title: Curr Opin Rheumatol
  contributor:
    fullname: Ihn, H
– volume: 10
  start-page: 536
  year: 2004
  end-page: 545
  article-title: Prevention of fibrosis in experimental colitis by captopril: The role of tgf-beta1
  publication-title: Inflamm Bowel Dis
  contributor:
    fullname: Pappo, O
– volume: 94
  start-page: 3279
  year: 1999
  end-page: 3284
  article-title: Expression of CD40 and its ligand, CD40L, in intestinal lesions of Crohn's disease
  publication-title: Am J Gastroenterol
  contributor:
    fullname: Resegotti, A
– volume: 49
  start-page: 777
  year: 2001
  end-page: 782
  article-title: Behaviour of Crohn's disease according to the Vienna classification: Changing pattern over the course of the disease
  publication-title: Gut
  contributor:
    fullname: Oger, A
– volume: 36
  start-page: 355
  year: 1993
  end-page: 361
  article-title: Long-term follow-up of strictureplasty in Crohn's disease
  publication-title: Dis Colon Rectum
  contributor:
    fullname: Lavery, IC
– volume: 172
  start-page: 1862
  year: 2004
  end-page: 1871
  article-title: Expression of CD154 (CD40 ligand) by human lung fibroblasts: Differential regulation by IFN-gamma and IL-13, and implications for fibrosis
  publication-title: J Immunol
  contributor:
    fullname: Phipps, RP
– volume: 379
  start-page: 821
  year: 1996
  end-page: 823
  article-title: Mapping of a susceptibility locus for Crohn's disease on chromosome 16
  publication-title: Nature
  contributor:
    fullname: Gower-Rousseau, C
– volume: 163
  start-page: 4049
  year: 1999
  end-page: 4057
  article-title: Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production
  publication-title: J Immunol
  contributor:
    fullname: D'Haens, GR
– volume: 15
  start-page: 89
  year: 2001
  end-page: 93
  article-title: Application of the Vienna Classification for Crohn's disease to a single clinician database of 877 patients
  publication-title: Can J Gastroenterol
  contributor:
    fullname: Freeman, HJ
– volume: 125
  start-page: 1750
  year: 2003
  end-page: 1761
  article-title: A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B
  publication-title: Gastroenterology
  contributor:
    fullname: Leite, AZ
– volume: 6
  start-page: 283
  year: 2002
  end-page: 294
  article-title: Antifibrotic role of inducible nitric oxide synthase
  publication-title: Nitric Oxide
  contributor:
    fullname: Magee, TR
– volume: 279
  start-page: G1307
  year: 2000
  end-page: G1322
  article-title: IGF-I and procollagen alpha1(I) are coexpressed in a subset of mesenchymal cells in active Crohn's disease
  publication-title: Am J Physiol Gastrointest Liver Physiol
  contributor:
    fullname: Mohapatra, NK
– volume: 231
  start-page: 46
  year: 2000
  end-page: 50
  article-title: Stricture formation in Crohn's disease: The role of intestinal fibroblasts
  publication-title: Ann Surg
  contributor:
    fullname: Fitzpatrick, JM
– volume: 96
  start-page: 501
  year: 2001
  end-page: 507
  article-title: Low mortality in ulcerative colitis and Crohn's disease in three regional centers in England
  publication-title: Am J Gastroenterol
  contributor:
    fullname: Grace, RH
– volume: 70
  start-page: 845
  year: 2002
  end-page: 857
  article-title: CARD15 NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease
  publication-title: Am J Hum Genet
  contributor:
    fullname: Cezard, JP
– volume: 30
  start-page: 909
  year: 1998
  end-page: 922
  article-title: Connective tissue growth factor: A novel regulator of mucosal repair and fibrosis in inflammatory bowel disease?
  publication-title: Int J Biochem Cell Biol
  contributor:
    fullname: Falk, W
– volume: 164
  start-page: 6174
  year: 2000
  end-page: 6179
  article-title: Monocyte chemoattractant protein-1 enhances gene expression and synthesis of matrix metalloproteinase-1 in human fibroblasts by an autocrine IL-1 alpha loop
  publication-title: J Immunol
  contributor:
    fullname: Mauch, C
– volume: 115
  start-page: 110
  year: 2005
  end-page: 115
  article-title: Time and dose effects of mitomycin C on extracellular matrix fibroblasts and proteins
  publication-title: Laryngoscope
  contributor:
    fullname: Thibeault, S
– volume: 359
  start-page: 62
  year: 2002
  end-page: 69
  article-title: Crohn's disease
  publication-title: Lancet
  contributor:
    fullname: Shanahan, F
– volume: 282
  start-page: C172
  year: 2002
  end-page: C182
  article-title: Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts
  publication-title: Am J Physiol Cell Physiol
  contributor:
    fullname: Tighe, PJ
– volume: 18
  start-page: 816
  year: 2004
  end-page: 827
  article-title: TGF-beta signaling and the fibrotic response
  publication-title: FASEB J
  contributor:
    fullname: Abraham, DJ
– volume: 37
  start-page: 584
  year: 2005
  end-page: 589
  article-title: Expression of matrix metalloproteinases-2 and -9 in intestinal tissue of patients with inflammatory bowel diseases
  publication-title: Dig Liver Dis
  contributor:
    fullname: Kubben, FJ
– volume: 9
  start-page: 281
  year: 2003
  end-page: 289
  article-title: Defining complex contributions of NOD2 CARD15 gene mutations, age at onset, and tobacco use on Crohn's disease phenotypes
  publication-title: Inflamm Bowel Dis
  contributor:
    fullname: Achkar, J
– volume: 45
  start-page: 771
  year: 2002
  end-page: 775
  article-title: Remicade does not abolish the need for surgery in fistulizing Crohn's disease
  publication-title: Dis Colon Rectum
  contributor:
    fullname: Koltun, WA
– volume: 285
  start-page: G529
  year: 2003
  end-page: G538
  article-title: Regulation of IL-11 expression in intestinal myofibroblasts: Role of c-Jun AP-1- and MAPK-dependent pathways
  publication-title: Am J Physiol Gastrointest Liver Physiol
  contributor:
    fullname: Yasui, H
– volume: 5
  start-page: 519
  year: 2001
  end-page: 530
  article-title: Connective tissue growth factor: an attractive therapeutic target in fibrotic renal disease
  publication-title: Expert Opin Ther Targets
  contributor:
    fullname: Godson, C
– volume: 35
  start-page: 333
  year: 2003
  end-page: 337
  article-title: Long-acting steroid injection after endoscopic dilation of anastomotic Crohn's strictures may improve the outcome: A retrospective case series
  publication-title: Endoscopy
  contributor:
    fullname: Saunders, B
– volume: 23
  start-page: 451
  year: 2006
  end-page: 463
  article-title: Review article: Infliximab therapy for inflammatory bowel disease-seven years on
  publication-title: Aliment Pharmacol Ther
  contributor:
    fullname: Vermeire, S
– volume: 123
  start-page: 679
  year: 2002
  end-page: 688
  article-title: Mutations in NOD2 are associated with fibrostenosing disease in patients with Crohn's disease
  publication-title: Gastroenterology
  contributor:
    fullname: Lin, YC
– volume: 14
  start-page: 187
  year: 2000
  end-page: 197
  article-title: A mechanism of suppression of TGF-beta SMAD signaling by NF-kappa B RelA
  publication-title: Genes Dev
  contributor:
    fullname: Liang, D
– volume: 10
  start-page: S11
  year: 2004
  end-page: S15
  article-title: Genetic origin of IBD
  publication-title: Inflamm Bowel Dis
  contributor:
    fullname: Hugot, JP
– volume: 94
  start-page: 257
  year: 1988
  ident: b4_230
  publication-title: Gastroenterology
  doi: 10.1016/0016-5085(88)90411-8
  contributor:
    fullname: Graham MF
– ident: b70_296
  doi: 10.1136/gut.47.1.57
– ident: b3_229
  doi: 10.1097/00054725-200401000-00009
– ident: b74_300
  doi: 10.1016/j.cardiores.2004.03.010
– volume: 16
  start-page: 1949
  year: 2002
  ident: b118_344
  publication-title: FASEB J
  doi: 10.1096/fj.02-0204fje
  contributor:
    fullname: Stratton R
– volume: 115
  start-page: 110
  year: 2005
  ident: b111_337
  publication-title: Laryngoscope
  doi: 10.1097/01.mlg.0000150694.08259.80
  contributor:
    fullname: Ferguson B
– start-page: 243
  volume-title: Growth factors and other aspects of wound healing: Biological and clinical implications
  year: 1988
  ident: b39_265
  contributor:
    fullname: Ehrlich HP
– ident: b83_309
  doi: 10.1053/gast.2000.20229
– volume: 30
  start-page: 699
  year: 1995
  ident: b19_245
  publication-title: Scand J Gastroenterol
  doi: 10.3109/00365529509096316
  contributor:
    fullname: Munkholm P
– volume: 33
  start-page: 21
  year: 1987
  ident: b92_318
  publication-title: Gastrointest Endosc
  doi: 10.1016/S0016-5107(87)71479-5
  contributor:
    fullname: Bedogni G
– ident: b42_268
  doi: 10.1016/S1357-2725(98)00046-6
– ident: b27_253
  doi: 10.1126/science.1103685
– ident: b31_257
  doi: 10.1136/gut.52.4.552
– ident: b114_340
  doi: 10.1097/00054725-200409000-00007
– ident: b116_342
  doi: 10.1046/j.1523-1755.2002.00462.x
– volume: 102
  start-page: 431
  year: 1992
  ident: b38_264
  publication-title: Gastroenterology
  doi: 10.1016/0016-5085(92)90087-F
  contributor:
    fullname: Matthes H
– ident: b40_266
  doi: 10.1016/0005-2795(75)90106-3
– ident: b25_251
  doi: 10.1097/00054725-200402001-00003
– ident: b69_295
  doi: 10.1016/j.dld.2005.02.011
– ident: b101_327
  doi: 10.1016/0016-5085(95)90121-3
– volume: 25
  start-page: 665
  year: 1984
  ident: b7_233
  publication-title: Gut
  doi: 10.1136/gut.25.6.665
  contributor:
    fullname: Rutgeerts P
– ident: b123_349
  doi: 10.1053/j.gastro.2003.08.027
– volume: 283
  start-page: G809
  year: 2002
  ident: b50_276
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.00057.2002
  contributor:
    fullname: Simmons J
– volume: 163
  start-page: 4049
  year: 1999
  ident: b87_313
  publication-title: J Immunol
  contributor:
    fullname: Liu Z
– ident: b51_277
  doi: 10.1074/jbc.M505291200
– ident: b80_306
  doi: 10.1111/j.1365-2036.2006.02786.x
– ident: b93_319
  doi: 10.1016/S0016-5107(00)70366-X
– ident: b36_262
  doi: 10.1097/00054725-200309000-00001
– ident: b100_326
  doi: 10.1001/archsurg.134.5.471
– volume: 101
  start-page: 2650
  year: 1998
  ident: b53_279
  publication-title: J Clin Invest
  doi: 10.1172/JCI1876
  contributor:
    fullname: Jobson TM
– ident: b78_304
  doi: 10.1046/j.1524-475X.1999.00477.x
– ident: b12_238
  doi: 10.1111/j.1572-0241.2001.03466.x
– volume: 88
  start-page: 1826
  year: 1985
  ident: b9_235
  publication-title: Gastroenterology
  doi: 10.1016/0016-5085(85)90007-1
  contributor:
    fullname: Whelan G
– ident: b77_303
  doi: 10.1093/molehr/5.10.950
– volume: 11
  start-page: 651
  year: 1976
  ident: b107_333
  publication-title: Scand J Gastroenterol
  doi: 10.1080/00365521.1976.12097167
  contributor:
    fullname: Bergman L
– ident: b29_255
  doi: 10.1053/gast.2002.32413
– volume: 279
  start-page: G1307
  year: 2000
  ident: b45_271
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.2000.279.6.G1307
  contributor:
    fullname: Pucilowska JB
– ident: b1_227
  doi: 10.1016/S0140-6736(02)07284-7
– volume: 12
  start-page: 1235
  year: 2006
  ident: b21_247
  publication-title: World J Gastroenterol
  doi: 10.3748/wjg.v12.i8.1235
  contributor:
    fullname: Cosnes J
– ident: b117_343
  doi: 10.1172/JCI200112020
– volume: 15
  start-page: 89
  year: 2001
  ident: b14_240
  publication-title: Can J Gastroenterol
  doi: 10.1155/2001/426968
  contributor:
    fullname: Freeman HJ
– ident: b34_260
  doi: 10.1097/00001574-200403000-00006
– ident: b88_314
  doi: 10.1681/ASN.2005020202
– volume: 29
  start-page: 588
  year: 1988
  ident: b17_243
  publication-title: Gut
  doi: 10.1136/gut.29.5.588
  contributor:
    fullname: Greenstein AJ
– volume: 54
  start-page: A78
  issue: 7
  year: 2005
  ident: b33_259
  publication-title: Gut
  contributor:
    fullname: Alvarez-Lobos M
– ident: b11_237
  doi: 10.1136/gut.2004.045294
– volume: 265
  start-page: 17238
  year: 1990
  ident: b73_299
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(17)44894-0
  contributor:
    fullname: MacNaul KL
– ident: b52_278
  doi: 10.1152/ajpgi.00051.2005
– ident: b85_311
  doi: 10.1016/j.jaci.2005.03.036
– ident: b2_228
  doi: 10.1053/j.gastro.2004.01.063
– ident: b23_249
  doi: 10.1038/35079114
– ident: b119_345
  doi: 10.1074/jbc.M413102200
– ident: b41_267
  doi: 10.1016/0014-4800(81)90030-7
– volume: 42
  start-page: 224
  year: 1989
  ident: b109_335
  publication-title: Digestion
  doi: 10.1159/000199850
  contributor:
    fullname: Ewe K
– volume: 99
  start-page: 956
  year: 1990
  ident: b8_234
  publication-title: Gastroenterology
  doi: 10.1016/0016-5085(90)90613-6
  contributor:
    fullname: Rutgeerts P
– ident: b110_336
  doi: 10.1016/S0161-6420(99)00019-6
– ident: b61_287
  doi: 10.1097/00002281-200211000-00009
– ident: b6_232
  doi: 10.1016/S0016-5085(99)70549-4
– volume: 282
  start-page: C172
  year: 2002
  ident: b46_272
  publication-title: Am J Physiol Cell Physiol
  doi: 10.1152/ajpcell.00048.2001
  contributor:
    fullname: McKaig BC
– ident: b94_320
  doi: 10.1055/s-2003-38145
– ident: b30_256
  doi: 10.1053/gast.2002.35393
– ident: b68_294
  doi: 10.1046/j.1365-2249.2000.01227.x
– ident: b90_316
  doi: 10.1006/clin.1998.4606
– volume: 54
  start-page: A17
  year: 2005
  ident: b82_308
  publication-title: Gut
  contributor:
    fullname: D'Haens G
– ident: b62_288
  doi: 10.1096/fj.03-1273rev
– ident: b32_258
  doi: 10.1046/j.1365-2036.2003.01536.x
– ident: b81_307
  doi: 10.1007/s10350-004-6296-8
– ident: b96_322
  doi: 10.1007/s10350-004-6294-x
– ident: b104_330
  doi: 10.1016/S0016-5085(99)70125-3
– ident: b16_242
  doi: 10.1136/gut.49.6.777
– volume: 63
  start-page: 144
  year: 1990
  ident: b43_269
  publication-title: Lab Invest
  contributor:
    fullname: Sappino AP
– ident: b13_239
  doi: 10.1097/00054725-200207000-00002
– ident: b48_274
  doi: 10.1097/00000658-200204000-00008
– volume: 164
  start-page: 6174
  year: 2000
  ident: b72_298
  publication-title: J Immunol
  doi: 10.4049/jimmunol.164.12.6174
  contributor:
    fullname: Yamamoto T
– ident: b124_350
  doi: 10.1136/gut.2005.068429
– ident: b115_341
  doi: 10.1006/niox.2001.0421
– ident: b20_246
  doi: 10.1111/j.1572-0241.2006.00463.x
– volume: 13
  start-page: 161
  year: 1978
  ident: b108_334
  publication-title: Scand J Gastroenterol
  doi: 10.3109/00365527809181743
  contributor:
    fullname: Wenckert A
– ident: b57_283
  doi: 10.1517/14728222.5.4.519
– ident: b49_275
  doi: 10.1016/j.jamcollsurg.2004.02.028
– ident: b122_348
  doi: 10.1038/sj.bjp.0704173
– ident: b102_328
  doi: 10.1053/j.gastro.2005.01.010
– ident: b5_231
  doi: 10.1111/j.1572-0241.2000.01779.x
– volume: 71
  start-page: 245
  year: 1976
  ident: b18_244
  publication-title: Gastroenterology
  doi: 10.1016/S0016-5085(76)80196-5
  contributor:
    fullname: Farmer RG
– volume: 279
  start-page: G653
  year: 2000
  ident: b44_270
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.2000.279.4.G653
  contributor:
    fullname: Pucilowska JB
– ident: b120_346
  doi: 10.1002/jcp.10275
– volume: 285
  start-page: G529
  year: 2003
  ident: b112_338
  publication-title: Am J Physiol Gastrointest Liver Physiol
  doi: 10.1152/ajpgi.00050.2003
  contributor:
    fullname: Bamba S
– ident: b35_261
  doi: 10.1016/j.it.2003.10.007
– ident: b22_248
  doi: 10.1038/35079107
– ident: b79_305
  doi: 10.1097/00000658-200001000-00007
– volume: 6
  start-page: 8
  year: 2000
  ident: b15_241
  publication-title: Inflamm Bowel Dis
  doi: 10.1097/00054725-200002000-00002
  contributor:
    fullname: Gasche C
– ident: b65_291
  doi: 10.1097/01.sla.0000189606.58343.cd
– ident: b47_273
  doi: 10.1016/0092-8674(92)90115-S
– ident: b113_339
  doi: 10.1172/JCI200112821
– ident: b106_332
  doi: 10.1136/gut.51.3.405
– ident: b105_331
  doi: 10.1136/gut.2005.076604
– ident: b95_321
  doi: 10.1007/BF02234814
– ident: b103_329
  doi: 10.1053/j.gastro.2004.05.010
– ident: b55_281
  doi: 10.1167/iovs.02-0860
– ident: b54_280
  doi: 10.1002/bjs.4453
– ident: b98_324
  doi: 10.1159/000087130
– ident: b24_250
  doi: 10.1086/339432
– volume: 172
  start-page: 1862
  year: 2004
  ident: b89_315
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.3.1862
  contributor:
    fullname: Kaufman J
– ident: b26_252
  doi: 10.1038/379821a0
– volume: 14
  start-page: 187
  year: 2000
  ident: b67_293
  publication-title: Genes Dev
  contributor:
    fullname: Bitzer M
– ident: b99_325
  doi: 10.1007/s10350-004-0692-4
– ident: b64_290
  doi: 10.1016/S0898-6568(02)00058-X
– ident: b121_347
  doi: 10.1111/j.1523-1755.2004.00710.x
– ident: b71_297
  doi: 10.1136/gut.47.1.63
– ident: b66_292
  doi: 10.1074/jbc.M210366200
– ident: b58_284
  doi: 10.1097/00002281-200111000-00010
– volume: 102
  start-page: 1920
  year: 1992
  ident: b37_263
  publication-title: Gastroenterology
  doi: 10.1016/0016-5085(92)90314-O
  contributor:
    fullname: Stallmach A
– ident: b86_312
  doi: 10.1111/j.1572-0241.1999.01538.x
– ident: b91_317
  doi: 10.1111/j.1365-2036.2005.02526.x
– ident: b10_236
  doi: 10.1016/S1072-7515(01)00775-X
– volume: 49
  start-page: 133
  year: 2002
  ident: b59_285
  publication-title: Hepatogastroenterology
  contributor:
    fullname: Hayashi N
– ident: b60_286
  doi: 10.1002/bjs.5431
– ident: b28_254
  doi: 10.1016/S0140-6736(02)08590-2
– ident: b56_282
  doi: 10.1006/jmcc.2000.1215
– volume: 162
  start-page: 1355
  year: 2003
  ident: b76_302
  publication-title: Am J Pathol
  doi: 10.1016/S0002-9440(10)63931-4
  contributor:
    fullname: McKaig BC
– ident: b84_310
  doi: 10.1681/ASN.2005030297
– ident: b97_323
  doi: 10.1007/BF02053938
– ident: b63_289
  doi: 10.1097/00000658-199901000-00009
– ident: b75_301
  doi: 10.1136/gut.50.1.65
SSID ssj0015275
Score 2.4003432
SecondaryResourceType review_article
Snippet Over one-third of patients with Crohn's disease (CD) will develop an intestinal stricture and the great majority of these will require at least one surgical...
INTRODUCTION:Over one-third of patients with Crohn's disease (CD) will develop an intestinal stricture and the great majority of these will require at least...
INTRODUCTIONOver one-third of patients with Crohn's disease (CD) will develop an intestinal stricture and the great majority of these will require at least one...
SourceID proquest
crossref
pubmed
pascalfrancis
nature
SourceType Aggregation Database
Index Database
Publisher
StartPage 439
SubjectTerms Biological and medical sciences
Crohn Disease - complications
Crohn Disease - pathology
Disease Progression
Fibrosis - complications
Fibrosis - pathology
Gastroenterology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Intestinal Obstruction - etiology
Intestinal Obstruction - pathology
Medical sciences
Other diseases. Semiology
Prognosis
Retrospective Studies
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Title Fibrogenesis in Crohn's Disease
URI http://dx.doi.org/10.1111/j.1572-0241.2006.01010.x
https://www.ncbi.nlm.nih.gov/pubmed/17156147
https://www.proquest.com/docview/1783694158
https://search.proquest.com/docview/69029098
Volume 102
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT8JAEJ4oJMbEGN9UEXow8dRId7vd7skoQogJxPhIuDWlu4t4aJFCws93ti0gBz023e7h2-nMfDOzMwA3Uo8IJ4o4REjheIoLJ2Jx5JhWbPjQ0iRvPN8f-L0P73nIhmXALSvLKlc6MVfUMo1NjPzONdcNBJqb4H767ZipUSa7Wo7Q2IWqS9CUozzz4ZpwmYmtbOX-CsJb25U8jBMHLZRbZiRcU-W13DJP6-aaB9MoQ8h0Mevib2c0N0rdIzgsvUn7oTj-Y9hRyQns9ct8-Sk0u8iG07HRZ5PMniR2e5Z-JreZ_VTkZc7grdt5b_ecciSCE1PB5qiaJNe-in1FKZd-TLVksUmmMckpMgn0liQTXoSLGVER45GmI84Ui904COg5VJI0UTWwSUsZZqGkp5WHlEVwSXVAledyrgNPW-CucAinRd-L8BdfQOxCg52ZYumHOXbh0oJaAdj6i-hrbGKhvm9BYwvCzZ4BIwH6TBbUV5iG5V-UhZszt6C5fo3yb5IaUaLSRRYiuyeiJXDFRXESm625a9qc8sv_t76C_SJea0pU6lCZzxbqGh2N-aiRS1MDqo-dwcvrD7tizAE
link.rule.ids 314,780,784,12056,21388,27924,27925,31719,31720,33744,33745,43310,43805,73745,74302
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3JTsMwEB1BKwESQuwECs0BiVNEY8dxfEIsrQq0FWKRuFlpbLMckkJaqZ-PnTgtPcAxijOHZ3u2N5kBOBVqiCiSyENMMC-QlHkxSWLPtGLTDy2Fisbz_UHYfQnuXsmrTbjltqyy0omFohZZYnLk57753YBpcxNdjL48MzXKsKt2hMYy1E3ndFKD-lV78PA44xEIoqRygBmircVaHkKRp22UbzkJ39R5TRcM1Ky95voozjVoqpx28bc7WpilziZsWH_SvSwPwBYsyXQbVvqWMd-BZkfHw9mb0WgfufuRutff2Xt6lrs3JTOzC0-d9vN117NDEbwEMzLWyklQFcoklBhTESZYCZIYOo0IinUsof0lQVgQ68UEyZjQWOEhJZIkfhJFeA9qaZbKA3BRS5rYQopAyUAHLYwKrCIsA59SFQXKAb_CgY_Kzhf8V8SgseMGOzPHMuQFdnzqwEEJ2OyL-PPNZEPD0IGTBQjnMiOCIu01OdCoMOX2HuV8vusONGev9Q0wtEacymyScx3fI9ZiesV-uRNz0dQ3jU7p4f-im7Dafe73eO92cH8Ea2X21hSsNKA2_p7IY-12jIcn9mz9AJ1Tzr0
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3JTsMwEB1BkRASQuyErTkgcYpI7DiOT4itYq0Qi8TNSmO7wCEpTSvx-Ywbt6UHOEZx5vAynsVvPANwpEyHcKJJQIQSQay5CDKWZ4FtxYYPoSGjxvMP7eT6Nb59Y2-u_qlyZZVjmzgy1KrM7Rn5SWSvGwh0N-mJcWURj5et095XYCdIWabVjdOYhwX0iiFpwML5VfvxacIpMMLZOBgWhIezdT2MkwD9VeT4icjWfH3POKtJq83lXlYhgKaefPF3aDpyUa1VWHGxpX9WK8MazOliHRYfHHu-Ac0W5sZl11q3j8r_KPyLfvleHFf-Zc3SbMJz6-rl4jpwAxKCnAo2QEOluEl0nmhKuUpyahTLLbXGFKeYV2DspJiIM1zMiM4YzwztcKZZHuVpSregUZSF3gGfhNrmGVrFRseYwAiuqEmpjiPOTRobD6IxDrJXd8GQv7IHxE5a7OxMy0SOsJPfHuzUgE2-yD679mQ0STw4nIFwKjNlJMUIyoP9MabS7alKTjXAg-bkNe4GS3FkhS6HlcRcn4hQ4Irt-k9MRfPINj3lu_-LbsIiqpW8v2nf7cFSfZBra1f2oTHoD_UBRiCDzqFTrR9_l9Lq
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Fibrogenesis+in+Crohn%27s+Disease&rft.jtitle=The+American+journal+of+gastroenterology&rft.au=Burke%2C+John+P&rft.au=Mulsow%2C+Jurgen+J&rft.au=O%27Keane%2C+Conor&rft.au=Docherty%2C+Neil+G&rft.date=2007-02-01&rft.issn=0002-9270&rft.eissn=1572-0241&rft.volume=102&rft.issue=2&rft.spage=439&rft.epage=448&rft_id=info:doi/10.1111%2Fj.1572-0241.2006.01010.x&rft.externalDBID=n%2Fa&rft.externalDocID=10_1111_j_1572_0241_2006_01010_x
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9270&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9270&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9270&client=summon