GSK3β is a checkpoint for TNF-α-mediated impaired osteogenic differentiation of mesenchymal stem cells in inflammatory microenvironments - Kong, Xiangwei; Liu, Yan; Ye, Ruidong; Zhu, Bin; Zhu, Yuan; Liu, Xianghui; Hu, Chenghu; Luo, Hailang; Zhang, Yongjie; Ding, Yin; Jin, Yan (Biochimica et biophysica acta, 2013)
Keywords: Adenoviridae; Adult; beta Catenin - metabolism; bone formation; Cell Differentiation - physiology; Cell Nucleus - metabolism; Cells, Cultured; Core Binding Factor Alpha 1 Subunit - metabolism; enzyme-linked immunosorbent assay; gene overexpression; Glycogen Synthase Kinase 3 - metabolism; Glycogen Synthase Kinase 3 beta; Glycogen synthase kinase 3β; Humans; Inflammation - metabolism; Inflammation - pathology; interleukin-1beta; interleukin-6; interleukin-8; Interleukins - metabolism; ligaments; Lymphoid Enhancer-Binding Factor 1 - metabolism; Mesenchymal stem cell; Mesenchymal Stromal Cells - metabolism; Mesenchymal Stromal Cells - pathology; monocytes; Monocytes - metabolism; Monocytes - pathology; Osteogenesis - physiology; Osteogenic differentiation; patients; Periodontal Ligament - metabolism; Periodontal Ligament - pathology; periodontitis; Periodontitis - metabolism; Periodontitis - pathology; phosphorylation; Phosphorylation - physiology; secretion; small interfering RNA; Stem Cell Niche - physiology; stem cells; tau-protein kinase; transcription (genetics); tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-α; Western blotting; Young Adult; Mesenchymal stem cell; Tumor necrosis factor-α; Osteogenic differentiation; Glycogen synthase kinase 3β