Canthin-6-one induces cell death, cell cycle arrest and differentiation in human myeloid leukemia cells - Vieira Torquato, Heron F.; Ribeiro-Filho, Antonio C.; Buri, Marcus V.; Araújo Júnior, Roberto T.; Pimenta, Renata; de Oliveira, José Salvador R.; Filho, Valdir C.; Macho, Antonio; Paredes-Gamero, Edgar J.; de Oliveira Martins, Domingos T. (Biochimica et biophysica acta. General subjects, 2017)
Keywords: antineoplastic activity; apoptosis; Apoptosis - drug effects; Biomarkers, Tumor - metabolism; Canthin-6-one; Carbolines - pharmacology; caspases; Cell cycle arrest; cell cycle checkpoints; Cell Cycle Checkpoints - drug effects; Cell death; Cell Death - drug effects; Cell differentiation; Cell Differentiation - drug effects; Cell Line, Tumor; Cell Lineage - drug effects; cyclins; cytotoxicity; DNA; fungi; Gene Expression Regulation, Leukemic - drug effects; Humans; Indole Alkaloids - pharmacology; K562 Cells; Leukemia; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - metabolism; Leukemic stem cells; mitochondria; Myeloid Cells - drug effects; Myeloid Cells - metabolism; myeloid leukemia; neoplasm cells; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; propidium; stem cells; transcription factors; Cell cycle arrest; Cell differentiation; Cell death; Leukemia; Leukemic stem cells; Canthin-6-one