Integrative epigenome-transcriptome analysis unravels cancer-specific over-expressed genes potentially regulating immune microenvironment in clear cell renal cell carcinoma

• Published in: Biochimica et biophysica acta. General subjects Vol. 1868; no. 5; p. 130596
• Main Authors: Gadewal, Nikhil, Natu, Abhiram, Sen, Siddhartha, Rauniyar, Sukanya, Bastikar, Virupaksha, Gupta, Sanjay
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2024
• Subjects: Carcinoma, Renal Cell - genetics; Carcinoma, Renal Cell - pathology; ccRCC; chromatin immunoprecipitation; data collection; DNA; DNA methylation; Epigenome; Gene Expression Profiling; gene ontology; histology; histone code; Histone modification; histones; Humans; Immune system; immunosuppression; immunotherapy; Kidney Neoplasms - genetics; Kidney Neoplasms - pathology; metastasis; multiomics; neoplasm progression; patients; prognosis; Receptors, Immunologic - genetics; renal cell carcinoma; transcriptome; Transcriptome - genetics; Tumor Microenvironment - genetics; TREML1; ccRCC; VWF; DNA methylation; Histone modification; TGFA; Epigenome; MSC; ADA; Immune system; RUNX1

Clear cell Renal Cell Carcinoma (ccRCC) is the frequently diagnosed histological life-threatening tumor subtype in the urinary system. Integrating multi-omics data is emerging as a tool to provide a comprehensive view of biology and disease for better therapeutic interventions. We have integrated fr...