Variation in the biological half-life of methylmercury in humans: Methods, measurements and meaning

• Published in: Biochimica et biophysica acta. General subjects Vol. 1863; no. 12; p. 129301
• Main Authors: Rand, Matthew D., Caito, Samuel W.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2019
• Subjects: Animals; biological half-life; Child; children; dosimetry; Female; fish; Half-Life; Humans; mercury; methylmercury compounds; Methylmercury Compounds - pharmacokinetics; Methylmercury Compounds - toxicity; Pregnancy; pregnant women; risk assessment process; Seafood - toxicity; seafood consumption; surveys; toxicity; Toxicokinetics; toxicology; uncertainty; United States Environmental Protection Agency

Understanding methylmercury (MeHg) toxicity requires a complete understanding of its fundamental toxicokinetic and toxicodynamic characteristics in the human body. The biological half-life (t1/2) of MeHg is a kinetic property that directly influences the body burden of Hg that results from repeated...