Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy

• Published in: Biochimica et biophysica acta. General subjects Vol. 1864; no. 4; p. 129539
• Main Authors: Wei, Yunpeng, Lv, Huanhuan, Shaikh, Atik Badshah, Han, Wei, Hou, Hongjie, Zhang, Zhihao, Wang, Shenghang, Shang, Peng
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2020
• Subjects: Cancer therapy; Ferroptosis; GPX4; GSH; iron; lipid peroxides; neoplasm cells; neoplasms; phospholipid-hydroperoxide glutathione peroxidase; System Xc; Ferroptosis; System Xc; GPX4; GSH; Cancer therapy; System X(c)(−)

Cancer is one of the major threats to human health and current cancer therapies have been unsuccessful in eradicating it. Ferroptosis is characterized by iron-dependence and lipid hydroperoxides accumulation, and its primary mechanism involves the suppression of system Xc−-GSH (glutathione)-GPX4 (gl...