The ever-changing roles of serotonin

• Published in: The international journal of biochemistry & cell biology Vol. 125; p. 105776
• Main Authors: Jones, Lauren A., Sun, Emily W., Martin, Alyce M., Keating, Damien J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.08.2020
• Subjects: adipocytes; Adipocytes - enzymology; Adipocytes - metabolism; adiposity; Animals; anxiety; blood-brain barrier; brain stem; Diabetes; digestive tract; Enteric Nervous System - metabolism; Enterochromaffin; Enterochromaffin Cells - enzymology; Enterochromaffin Cells - metabolism; enzymes; essential amino acids; Gastrointestinal; Gastrointestinal Microbiome - physiology; gastrointestinal motility; Gastrointestinal Motility - physiology; Gastrointestinal Tract - enzymology; Gastrointestinal Tract - metabolism; Gastrointestinal Tract - microbiology; Glucose; Glucose - metabolism; Homeostasis; Humans; intestinal microorganisms; Metabolism; metabolites; Microbiome; Microbiota; Neurons - enzymology; Neurons - metabolism; neurotransmitters; Obesity; Obesity - metabolism; serotonin; Serotonin - metabolism; sleep; Tph1; tryptophan; Tryptophan Hydroxylase - metabolism; Tryptophan hydroxylase 1; Enterochromaffin; Obesity; Microbiota; Tph1; Tryptophan hydroxylase 1; Diabetes; Glucose; Metabolism; Gastrointestinal; Microbiome

Serotonin (5-HT) has traditional roles as a key neurotransmitter in the central nervous system and as a regulatory hormone controlling a broad range of physiological functions. Perhaps the most classically-defined functions of 5-HT are centrally in the control of mood, sleep and anxiety and peripher...