Inhibiting protein aggregation with nanomaterials: The underlying mechanisms and impact factors

• Published in: Biochimica et biophysica acta. General subjects Vol. 1866; no. 2; p. 130061
• Main Authors: Wang, Shilin, Zheng, Jiaojiao, Ma, Liang, Petersen, Robert B., Xu, Li, Huang, Kun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2022
• Subjects: Amyloid; Amyloidogenic Proteins - chemistry; Amyloidogenic Proteins - metabolism; Animals; Humans; Impact factors; Mechanism; Nanomaterials; Nanostructures - chemistry; Protein Aggregates; Protein Aggregation, Pathological - metabolism; protein folding; Protein misfolding diseases; Proteostasis Deficiencies - drug therapy; Proteostasis Deficiencies - metabolism; Proteostasis Deficiencies - pathology; therapeutics; toxicity; HI; T2DM; BBB; TDP 43; BI; ALS; HTT; PMDs; Mechanism; Aβ; BSA; PTT; SPR; FTIR; α-Syn; HSA; MD; β-lg; Amyloid; hIAPP; CD; AD; TSE; Impact factors; Nanomaterials; HEWL; PD; NIR; HD; PTA; Protein misfolding diseases; TEM; ThS

Protein aggregation is correlated with the onset and progression of protein misfolding diseases (PMDs). Inhibiting the generation of toxic aggregates of misfolded proteins has been proposed as a therapeutic approach for PMDs. Due to their unique properties, nanomaterials have been extensively invest...