Discovery of fluorescent coumarin-benzo[b]thiophene 1, 1-dioxide conjugates as mitochondria-targeting antitumor STAT3 inhibitors - Cai, Guiping; Yu, Wenying; Song, Dongmei; Zhang, Wenda; Guo, Jianpeng; Zhu, Jiawen; Ren, Yuhao; Kong, Lingyi (European journal of medicinal chemistry, 2019)
Keywords: Antitumor activity; Benzo[b]thiophene 1, 1-Dioxide; Chemistry, Medicinal; Life Sciences & Biomedicine; Mitochondrial apoptosis pathway; N, N-Diethyl-7-aminocoumarin fluorophore; Pharmacology & Pharmacy; Science & Technology; Ser727 phosphorylation; STAT3; PBS; rt; Src; DMSO; STAT3; Ser727 phosphorylation; N, N-Diethyl-7-aminocoumarin fluorophore; MTT; Mitochondrial apoptosis pathway; STAT; FBS; ROS; Antitumor activity; PI; Benzo[b]thiophene 1, 1-Dioxide; TMS; JAK2; SH2; GAPDH; JC-1; Erk; ACTIVATION; DESIGN; TRANSCRIPTION; SERINE PHOSPHORYLATION; CANCER; SMALL-MOLECULE INHIBITOR; TYROSINE; BIOLOGICAL EVALUATION; DERIVATIVES; SIGNAL TRANSDUCER