SFRP1 variations influence susceptibility and immune response to Mycobacterium tuberculosis in a Chinese Han population

• Published in: Infection, genetics and evolution Vol. 37; pp. 259 - 265
• Main Authors: Zhao, Zhenzhen, Peng, Wu, Hu, Xuejiao, Zhang, Jingya, Shang, Mengqiao, Zhou, Juan, Zhou, Yi, Song, Xingbo, Lu, Xiaojun, Ying, Binwu, Chen, Xuerong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2016
• Subjects: Adult; alleles; Bacterial Proteins - metabolism; Case-Control Studies; China - ethnology; Chinese people; Female; gene frequency; Genetic Predisposition to Disease; genotyping; haplotypes; heterozygosity; Humans; immune response; inflammation; Inflammatory markers; Intercellular Signaling Peptides and Proteins - genetics; loci; Male; Membrane Proteins - genetics; Middle Aged; Models, Genetic; Mycobacterium tuberculosis; neoplasms; patients; Polymorphism, Single Nucleotide; risk; Secreted frizzled-related protein 1 (SFRP1); signal transduction; single nucleotide polymorphism; Single nucleotide polymorphisms (SNPs); Tuberculosis; Tuberculosis - ethnology; Tuberculosis - genetics; Tuberculosis - immunology; Young Adult; Secreted frizzled-related protein 1 (SFRP1); Single nucleotide polymorphisms (SNPs); Inflammatory markers; Tuberculosis

SFRP1 acts as a well-established inhibitory regulator of the Wnt signaling pathway, whose polymorphisms have been demonstrated to be associated with the risk of inflammation, infection as well as cancer. We verified the hypothesis that single nucleotide polymorphisms (SNPs) within SFRP1 gene are ass...