PcFKH1, a novel regulatory factor from the forkhead family, controls the biosynthesis of penicillin in Penicillium chrysogenum

• Published in: Biochimie Vol. 115; pp. 162 - 176
• Main Authors: Domínguez-Santos, Rebeca, García-Estrada, Carlos, Kosalková, Katarina, Prieto, Carlos, Santamarta, Irene, Martín, Juan-Francisco
• Format: Journal Article
• Language: English
• Published: France Elsevier B.V 01.08.2015
• Subjects: Acyltransferases - deficiency; Binding Sites; biosynthesis; cell death; Cell Division; conidiation; DNA - metabolism; Forkhead; Forkhead Transcription Factors - deficiency; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Fungal Proteins - genetics; Fungal Proteins - metabolism; Gene Expression Regulation, Fungal; gene overexpression; Gene Silencing; genes; Genomics; humans; hyphae; messenger RNA; morphogenesis; mutants; Penicillin biosynthesis; Penicillin G - metabolism; penicillins; Penicillins - biosynthesis; Penicillins - metabolism; Penicillium chrysogenum; Penicillium chrysogenum - cytology; Penicillium chrysogenum - genetics; Penicillium chrysogenum - metabolism; Pigmentation; promoter regions; Promoter Regions, Genetic - genetics; regulatory proteins; Sequence Homology, Nucleic Acid; spores; Spores, Fungal - metabolism; transcription (genetics); transcription factors; Transcriptional regulation; Winged-helix; yeasts; Penicillin biosynthesis; Forkhead; ACV; IPN; Winged-helix; Transcriptional regulation; IAT; PPTase; Penicillium chrysogenum

Penicillin biosynthesis in Penicillium chrysogenum (re-identified as Penicillium rubens) is a good example of a biological process subjected to complex global regulatory networks and serves as a model to study fungal secondary metabolism. The winged-helix family of transcription factors recently des...