Backbone modified TBA analogues endowed with antiproliferative activity - Esposito, Veronica; Russo, Annapina; Amato, Teresa; Varra, Michela; Vellecco, Valentina; Bucci, Mariarosaria; Russo, Giulia; Virgilio, Antonella; Galeone, Aldo (Biochimica et biophysica acta. General subjects, 2017)
Keywords: anticoagulant activity; anticoagulants; Anticoagulants - chemistry; Anticoagulants - metabolism; Anticoagulants - pharmacology; Antineoplastic Agents - chemistry; Antineoplastic Agents - metabolism; Antineoplastic Agents - pharmacology; Antiproliferative activity; Aptamers; Aptamers, Nucleotide - chemistry; Aptamers, Nucleotide - metabolism; Aptamers, Nucleotide - pharmacology; Base Sequence; Blood Coagulation - drug effects; cell lines; Cell Proliferation - drug effects; Circular Dichroism; Drug Stability; Esterases - chemistry; fetal bovine serum; G-quadruplex; G-Quadruplexes; HCT116 Cells; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; neoplasms; Neoplasms - drug therapy; Neoplasms - pathology; nuclear magnetic resonance spectroscopy; oligonucleotides; Protein Binding; Structure-Activity Relationship; TBA analogues; thrombin; Thrombin - analogs & derivatives; Thrombin - chemistry; Thrombin - metabolism; Thrombin - pharmacology; Time Factors; TBA analogues; Antiproliferative activity; Aptamers; G-quadruplex